Targeting Macrophage Iron in Nonalcoholic Steatohepatitis (NASH) [0.03%]
靶向巨噬细胞中铁离子可改善非酒精性脂肪肝病(NASH)
James F Collins
James F Collins
"Gut microbiome-mediated nutrients alter opportunistic bacterial growth in peritonitis" [0.03%]
"肠道微生物介导的营养物质改变腹膜炎时条件致病菌的生长"
Kale S Bongers,Thomas L Flott,Larisa Yeomans et al.
Kale S Bongers et al.
Peritonitis is a well-known complication of bowel perforation and abdominal surgery, leading to sepsis and high mortality. Despite its prevalence and severity, the pathogenesis of peritonitis remains incompletely understood, limiting our ab...
Distinct Molecular Responses of Human Intestinal Organoids to Proton and Photon Radiation [0.03%]
人肠道类器官对质子和光子辐射的不同分子反应
Victoria Poplaski,Tajhal D Patel,Hoa Nguyen-Phuc et al.
Victoria Poplaski et al.
Radiation exposure impairs rapidly renewing tissues like the intestinal epithelium, yet translational insights from murine models have been limited by species-specific responses. Here, we use human intestinal organoids (HIOs) derived from j...
Beyond Fructolysis: Ketohexokinase Orchestrates ER Proteostasis in Nutrient-Stressed Hepatocytes [0.03%]
超越果糖裂解：酮体己糖激酶在营养应激肝细胞中调控内质网蛋白稳态
Salaheldeen Elsaid,Xiangdong Wu,Junkai Hu et al.
Salaheldeen Elsaid et al.
Excessive intake of fructose and fats disrupt hepatocyte function by overwhelming endoplasmic reticulum (ER) capacity, leading to unresolved protein stress and progression to metabolic dysfunction-associated steatohepatitis (MASH)1. Ketohex...
Sex Dimorphism and Substrate Dependency of Liver Mitochondrial Bioenergetics and H2O2 Production [0.03%]
性别二态性和基质依赖性对肝脏线粒体生物能量和H2O2产生的影响
Devanshi D Dave,Pardis Taheri,Sri Rahavi Boovarahan et al.
Devanshi D Dave et al.
Mitochondrial bioenergetics and H2O2 production play a central role in maintaining liver metabolic function and redox balance. Understanding sex dimorphism and substrate dependency in these mitochondrial processes is crucial for elucidating...
Loss of hepatic alpha-1b adrenoceptor exacerbates inflammation and stellate cell activation in diet-induced MASLD [0.03%]
肝α-1b肾上腺素受体的丧失加剧了饮食诱导的MASLD炎症和星状细胞活化
Bernie Efole,Sarra Beji,Mathilde Mouchiroud et al.
Bernie Efole et al.
The brain regulates liver metabolism through neuroendocrine and autonomic pathways, which can be disrupted in metabolic dysfunction-associated steatotic liver disease (MASLD). While autonomic dysfunction, including liver neuropathy, has bee...
N-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport [0.03%]
N-糖链对SLC26A3不会显著改变质膜或脂筏转运，但似乎稳定了结构域间接触以刺激转运
Sophie Achilles,Jan-Niklas Tomczak,Fabiane-Samira Baumann et al.
Sophie Achilles et al.
DRA (SLC26A3) is a major apical intestinal Cl-/HCO3- exchanger, which is expressed in complex and hybrid N-glycosylated forms. While the importance of N-glycosylation is evident from the significantly reduced transport activity of non-N-gly...
m6A mRNA Methylation Decorates Genes Involved in Fibrinogen Synthesis to Regulate Liver Regeneration in Mice [0.03%]
m6A mRNA甲基化修饰参与纤维蛋白原合成相关基因以调控小鼠肝再生
Tomohiko Kimura,Dario F De Jesus,Hyunki Kim et al.
Tomohiko Kimura et al.
The role of m6A RNA methylation in liver regeneration is unclear. This study aimed to determine the role of m6A methylation in liver regeneration after a 70% hepatectomy (HEPA) using liver specific Mettl 14 KO male mice. Analysis was conduc...
Retatrutide Improves Steatohepatitis in an Accelerated Mouse Model of Diet-Induced Steatohepatitis with a Fructose Binge [0.03%]
雷塔鲁肽可改善高果糖饮食诱导的非酒精性脂肪肝病小鼠模型中的 steatohepatitis 病变
Greta Karoline Viebahn,Amit Khurana,Linton Freund et al.
Greta Karoline Viebahn et al.
Fructose consumption contributes to metabolic dysfunction-associated steatohepatitis (MASH). Retatrutide is a novel triple receptor agonist that improves obesity and hepatic steatosis in humans. The aims of this study were to develop a shor...
Hepatic protein kinase Cbeta antagonizing p38MAPK to activate ERK1/2 to dysregulate biliary lipid composition upon lithogenic stress [0.03%]
胆汁淤积性刺激时肝脏蛋白激酶Cβ通过对抗p38MAPK激活ERK1/2而导致胆汁脂质组成失常
Yaoling Shu,Amit Rai,Gina M Sizemore et al.
Yaoling Shu et al.
Lithogenic diet exposure disrupts biliary lipid homeostasis to promote precipitation of excess biliary cholesterol; however, the underlying pathogenic signaling mechanism remains unclear. Protein kinase Cbeta (PKCβ) is involved in regulati...