A novel human hepatocyte cell line to study PNPLA3-associated steatotic liver disease [0.03%]
一种新型的人肝细胞系用于研究与PNPLA3相关的脂肪变性肝病
Gary Huang,Daniel F Wallace,V Nathan Subramaniam
Gary Huang
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) p.I148M is a well-established variant associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MAS...
Geoffrey E Hespe,Raghu P Kataru
Geoffrey E Hespe
Srinivas N Puttapaka,Subhash Kulkarni
Srinivas N Puttapaka
Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects [0.03%]
吲哚胡椒酸通过增强屏障功能而非抗炎作用来保护中等多样性的结肠炎小鼠
Kristoff M Nieves,Kyle L Flannigan,Elizabeth Hughes et al.
Kristoff M Nieves et al.
Metabolites generated from the intestinal microbiota regulate local and distant tissues. One important metabolite generated from L-tryptophan is indole-3-propionic acid (IPA), which has been shown previously to regulate intestinal mucosal h...
Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice [0.03%]
高脂饮食与胃食管交界处鳞柱交界旁腺分泌的酸性胆盐可能通过促进瓦堡效应共同促进gan小鼠胃癌发生发展
Koichiro Sudo,Kaname Uno,Toru Tamahara et al.
Koichiro Sudo et al.
Epidemiological studies demonstrated relationships between gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS). We aimed to clarify mechanism underlying their relationship. To investigate whether systemic inflammation against ...
Chronic intermittent hypoxia alleviates alcohol-related liver injury via downregulation of hepatic hypoxia-inducible factor-2α [0.03%]
慢性间歇性低氧通过下调肝脏缺氧诱导因子-2α来缓解酒精相关肝损伤
Yunling Chen,Dongyuan Zhang,Yunxiao Wu et al.
Yunling Chen et al.
Background: Alcohol-related liver disease (ALD) is one of the leading causes of alcohol-related morbidity and mortality worldwide. Unfortunately, limited therapeutic options are currently available, due to the complex ris...
Tritrichomonas muris sensitizes the intestinal epithelium to doxorubicin-induced apoptosis [0.03%]
鼠小隐球菌 Tritrichomonas muris 使肠道上皮细胞对多柔比星诱导的凋亡敏感化
Nicolas V Janto,Antoine R Gleizes,Siyang J Sun et al.
Nicolas V Janto et al.
Doxorubicin (DXR) is a widely used chemotherapy drug that can induce severe intestinal mucositis. While the influence of gut bacteria on DXR-induced damage has been documented, the role of eukaryotic commensals remains unexplored. We discov...
Oryzanol Ameliorates MCD-Induced Metabolic dysfunction-associated Steatohepatitis in Mice via Gut Microbiota Reprogramming and TLR4/NF-κB Signaling Suppression [0.03%]
通过肠道微生物群重编程和抑制TLR4 / NF-κB信号传导，稻米醇改善MCD诱导的代谢功能障碍相关性肝炎
Naqash Alam,Xinhua Ding,Yu Fu et al.
Naqash Alam et al.
Introduction: Metabolic dysfunction-associated steatohepatitis (MASH) has emerged as a major global health concern that affects about a quarter of the global population. Recently, host-gut microbiota metabolic interactions have emerged as k...
Saturated Phosphatidic Acids Induce mTORC1-Driven Integrated Stress Response Contributing to Glucolipotoxicity in Hepatocytes [0.03%]
饱和磷脂酸通过激活mTORC1诱导ISR参与肝细胞糖脂毒性
Rui Guo,Yanhui Li,Yuwei Jiang et al.
Rui Guo et al.
Hepatic glucolipotoxicity, characterized by the synergistic detrimental effects of elevated glucose levels combined with excessive lipid accumulation in hepatocytes, plays a central role in the pathogenesis of various metabolic liver diseas...
Functional roles of interstitial cells of Cajal in the GI tract of rats [0.03%]
Cajal间质细胞在大鼠胃肠道的功能作用
Sung Jin Hwang,Joong Goo Kwon,Elizabeth A H Beckett et al.
Sung Jin Hwang et al.
Interstitial cells of Cajal (ICC) are distributed through the gastrointestinal (GI) tract, but the functional role of these cells comes primarily from studies of mice. Whether functions of ICC are similar in larger animals is largely specul...