Age-Associated Patterns of Cardiovascular Risk and Disease Phenotypes Across Diverse Care Settings: The GLOB-cAGE Consortium [0.03%]
GLOB-cAGE联盟：不同医疗环境下心血管风险和疾病表型的年龄相关模式
Enyu Yang,Jie Sun,Yanhong Dong et al.
Enyu Yang et al.
Reported prevalence of cardiovascular disease (CVD) risk factors and phenotypes varies widely. In multi-cohort analyses, such variation reflects population risk, care setting, and data capture. We harmonized baseline data from four analytic...
Overlooked and ignored for too long: Investigation of regional and sex-related differences in vascular reactivity along the murine aorta [0.03%]
长久以来被忽视和忽略的：关于小鼠主动脉沿长度方向上血管反应性地区域性和性别差异的研究
Andrew P Braun,Michael A Hill
Andrew P Braun
A peripheral perspective on brain health: vascular and skeletal muscle contributions [0.03%]
从周边角度看待脑健康：血管和骨骼肌的贡献
Joshua L Keller,Kase J Pennartz,Justin D Sprick et al.
Joshua L Keller et al.
Age- and disease-related declines in brain health contribute to impairments in physical function, yet effective approaches to lessen these declines remain limited. Overall health is governed by a network of interdependent organ systems, suc...
A Cross-Sectional Analysis of Vascular Geometry in Adults: Associations of Age and Biological Sex with Iliofemoral Arterial and Venous Tortuosity [0.03%]
成人血管几何结构的横断面分析：年龄和生物性别与髂股动脉和静脉曲张的关系
Pauline M Berens,Benjamin C Liu,Arash Fereydooni et al.
Pauline M Berens et al.
Iliofemoral vascular tortuosity may reflect vascular aging, yet natural anatomic variation remains poorly characterized at scale. In this single-center retrospective study, we quantified arterial and venous iliofemoral tortuosity in a large...
From Gut to Heart: The Emerging Role of Dietary Fermentable Fiber in Heart Failure with Preserved Ejection Fraction [0.03%]
从肠道到心脏：可发酵纤维在射血分数保留型心力衰竭中的作用初探
Faisal Darbar,Medha Priyadarshini,Yueyang Wang et al.
Faisal Darbar et al.
Heart failure with preserved ejection fraction (HFpEF) is a multisystemic syndrome that accounts for more than half of all heart failure cases and causes a substantial burden of morbidity and mortality. In contrast to heart failure with red...
Sex as a Biological Variable in Cardiovascular-Kidney-Metabolic Syndrome: Lessons from a Diet-Induced Mouse Model [0.03%]
心血管-肾脏-代谢综合征中的性别生物学差异：饮食诱导的小鼠模型带来的启示
Horacio Osorio-Alonso,Laura G Sánchez-Lozada
Horacio Osorio-Alonso
Anti-TNF, Pan-JAK, and JAK1-Selective Inhibition Differentially Alter Mechanisms of Flow-Mediated Dilation in Human Microvessels [0.03%]
抗TNF、泛JAK和JAK1选择性抑制剂对人类微血管流量介导的扩张机制的不同影响
Annie Kleynerman Roels,Erin C Birch,Yoshinori Nishijima et al.
Annie Kleynerman Roels et al.
Patients with chronic inflammatory disorders, including inflammatory bowel disease (IBD), carry an increased risk of cardiovascular disease. The 2022 ORAL Surveillance study reported that the pan-selective Janus kinase inhibitor (JAKi) tofa...
Fetal programming under hyperglycemic stress: The vascular system at risk [0.03%]
高血糖压力下的胎儿编程：血管系统面临的风险
Fabiano E Xavier
Fabiano E Xavier
Maternal hyperglycemia, arising from pregestational or gestational diabetes, affects approximately 19% of pregnancies worldwide. Beyond its immediate obstetric and neonatal consequences, it may leave a durable imprint on vascular developmen...
Gestational diabetes promotes future maternal cardiovascular disease through endothelin activation and suppressed NO/cGMP/PRKG and AMPK/SIRT1 signaling pathways [0.03%]
妊娠糖尿病通过内皮素激活和抑制NO/cGMP/PRKG及AMPK/SIRT1信号通路促进未来母体心血管疾病的发展
Olufunto O Badmus,Sally Wahba,Gertrude Arthur et al.
Olufunto O Badmus et al.
Women with gestational diabetes mellitus (GDM) are more likely to develop cardiovascular disease (CVD) within 3 to 10 years following pregnancy. Despite a return to normoglycemia shortly after gestation, GDM mothers still possess an increas...
Cardiomyocyte-specific expression of HIF-1a mediates the cardioprotective effects of Growth Hormone Releasing Hormone (GHRH) [0.03%]
GH分泌激素通过心脏特异性HIF-1α介导的机制发挥心血管保护作用
Rosemeire M Kanashiro-Takeuchi,Lauro M Takeuchi,Wayne Balkan et al.
Rosemeire M Kanashiro-Takeuchi et al.
Heart failure (HF) with preserved ejection fraction (HFpEF) carries a high mortality and remains a major therapeutic challenge. Effective, targeted therapies capable of reversing HFpEF pathophysiology are urgently needed. We previously demo...