Endothelial Function: A Novel Marker to Evaluate the Prognosis of Heart Failure with Reduced Ejection Fraction [0.03%]
心功能障碍：评估射血分数降低的心力衰竭预后的新标志物
Salma Charfeddine,Mohamed Ali Hbaieb,Niez Laribi et al.
Salma Charfeddine et al.
Background Endothelial function, a key determinant of prognosis in heart failure with reduced ejection fraction (HFrEF), is still frequently under-assessed in clinical practice. The present study aimed to assess endothelial function in pati...
Cellular and Molecular Signals of Cardiac Wound Healing After Myocardial Infarction [0.03%]
心肌梗死后心脏伤口愈合的细胞和分子信号
Hiroe Toba,Ganesh V Halade,Kristine Y DeLeon-Pennell et al.
Hiroe Toba et al.
Wound healing after myocardial infarction (MI) is a dynamic and multifaceted process that links the molecular alterations induced by or in response to prolonged ischemia with structural and physiological changes to the damaged myocardium. C...
Vascular Endothelial Function Is Preserved in Women With a History of Preeclampsia Currently Receiving Antidepressant Pharmacotherapy [0.03%]
抗抑郁药治疗不能逆转妊娠期高血压疾病的内皮功能影响
Ruda Lee,Jody L Greaney,Mark K Santillan et al.
Ruda Lee et al.
Women with a history of preeclampsia (hxPE) have elevated risk of cardiovascular disease, likely in part from reduced endothelial function. Preeclampsia is also associated with increased risk of depression. While evidence indicates that ant...
Eplerenone lowers maternal blood pressure in a model of leptin-induced preeclampsia, but decreases fetal growth when administered mid-, but not late-, gestation [0.03%]
依普利酮可降低瘦素诱导的子痫前期模型中的母体血压，但其在妊娠中期而非晚期给药时可抑制胎仔生长发育
Elisabeth Mellott,Desmond Moronge,Gibson Cooper et al.
Elisabeth Mellott et al.
Preeclampsia induces adverse cardiovascular outcomes for both mother and offspring. We established a novel leptin-induced mouse model of preeclampsia that induces hypertension, endothelial dysfunction, and fetal growth restriction, which ar...
Endurance Exercise Induces Distinct Skeletal and Cardiac Mitochondrial Adaptations in Racehorses [0.03%]
耐力运动诱导赛马骨骼和心脏线粒体特异性适应性反应
Simon Libak Haugaard,Mélodie J Schneider,Sarah Dalgas Nissen et al.
Simon Libak Haugaard et al.
Mitochondrial respiration sustains the high energy demands of endurance exercise, yet the extent to which atrial, ventricular and skeletal muscle mitochondria adapt remains uncertain. At the same time, endurance athletes face an increased r...
Women-specific right ventricular-pulmonary arterial adaptation in healthy aging [0.03%]
健康老化女性右心室-肺动脉的特异性适应性变化
Benoit Aguado,Emmanuelle Berthelot,David Montani et al.
Benoit Aguado et al.
Federica Piani,Lorenzo Annesi,Daniela Degli Esposti et al.
Federica Piani et al.
Hypertensive disorders of pregnancy (HDP), particularly early-onset preeclampsia (EOPE), are major causes of perinatal morbidity and mortality. While impaired placentation has long been recognized as a key mechanism, increasing evidence hig...
Sex-Dependent Differences in Bioenergetics of Young Mouse Brain Microvasculature: Implications for Oxygen-Glucose Deprivation and Reoxygenation Injury [0.03%]
性别依赖的年轻小鼠脑微血管生物能量学差异：对缺氧-葡萄糖损伤和再充氧损伤的意义
Venkata N Sure,Lokanatha Oruganti,Siva S V P Sakamuri et al.
Venkata N Sure et al.
Sex differences are evident in vascular mitochondrial function, however, the impact of sex on microvascular bioenergetics has never been studied. We investigated the bioenergetics of freshly isolated mouse brain microvessels (BMVs) from you...
Sex and Stimulus-Specific Differences in Endothelial Cell Senescence Under Hormone-Free Conditions [0.03%]
无激素培养基中内皮细胞衰老的性别及特定刺激差异研究
Anna Quarder,Khaoula Talbi,Hannah Bartmann et al.
Anna Quarder et al.
Sex differences in cardiovascular disease are well documented, with females often considered hormonally protected. However, some differences persist even after menopause, indicating non-hormonal influences. Endothelial dysfunction is an ear...
Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis [0.03%]
柯萨奇病毒B3诱导的心肌炎中β-arr2调控心肌细胞cGAS-STING介导的炎症反应
Emilio Y Lucero,Haoran Jiang,Vincent D&#x;Anniballe et al.
Emilio Y Lucero et al.
Viral myocarditis is a major cause of sudden cardiac death and can lead to dilated cardiomyopathy in adults. However, effective treatments remain elusive due to an incomplete understanding of its molecular drivers. Here, we investigate the ...