Gary F Nieman,Egidio Beretta,Joaquin Araos et al.
Gary F Nieman et al.
Karl von Neegaard's classic publication, in 1929, first identified the physiologic function of pulmonary surfactant on alveolar mechanics. Dr. John Allen Clements brought this work to the clinic in the 1960s, culminating in the development ...
Intrauterine inflammation induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation [0.03%]
宫内炎症通过琥珀酸介导的肺泡上皮E-钙黏蛋白下调导致新生儿肺损伤
Baihe Li,Ze Chen,Dongting Yao et al.
Baihe Li et al.
Intrauterine inflammation is associated with lung injury in offspring and long-term adverse pulmonary outcomes, but the underlying mechanism remains elusive. This study aimed to investigate the underlying molecular mechanism from the perspe...
CFTR-Independent Prostaglandin E2-Stimulated Chloride Secretion in Human Airway [0.03%]
人呼吸道中独立于CFTR的前列腺素E2刺激的氯离子分泌
Shayda M Abazari,Ghazal Masarweh,Jesse Gammons et al.
Shayda M Abazari et al.
Background: Prostaglandin E2 (PGE2) is a potent stimulator of airway epithelial Cl- secretion. PGE2 can stimulate CFTR-independent Cl- secretion from Calu-3 submucosal gland cells, whereas human bronchial epithelial (HBE) cells require CFTR...
Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia [0.03%]
女性代谢性酸中毒和肺炎时碳酸酐酶IX促进急性肺损伤和死亡率升高
Reece P Stevens,Jacob Holston,Karam Maatouk et al.
Reece P Stevens et al.
Carbonic anhydrase IX (CA IX) is a unique transmembrane CA isoform that is associated with chronic pulmonary vascular diseases and is upregulated in the lungs during infection. Whether CA IX contributes to alveolar-capillary dysfunction in ...
Low tidal-volume-ventilation facilitated spontaneous increase in bronchoconstriction and air trapping: resolution by deep inspiration and bronchodilator [0.03%]
小潮气量通气促进支气管收缩和气体陷闭的自发加重：深吸气和舒张药物可缓解病情
Yuto Yasuda,Geoffrey N Maksym,Lu Wang et al.
Yuto Yasuda et al.
Background: Prolonged absence of deep inspiration (DI) increases airway resistance. The underlying mechanism is not entirely clear. We hypothesize that DI prohibition allows basal airway smooth muscle (ASM) tone to narrow and close airways ...
Lung-specific TGFβ overexpression increases airway fibrosis and airway contractility in transgenic mice [0.03%]
肺特异性TGFβ过表达增加转基因小鼠气道纤维化和气道收缩力
Julia G Chitty,Maggie Lam,Weiyi Mao et al.
Julia G Chitty et al.
Transforming growth factor beta 1 (TGFß1) is a pleiotropic cytokine implicated in the pathophysiology of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. Epithelial TGFß1 is released in response to injury, i...
Understanding and manipulating morphogenetic processes to generate in vitro models of airways [0.03%]
理解并操控形态发生过程以生成气道的体外模型
Katharina Raasch,Pauline Henrot,Alice Hadchouel et al.
Katharina Raasch et al.
Branching morphogenesis, the process by which cells and tissues organise into complex branched tubular structures, is fundamental to the development of functional organs, including the respiratory airways in mammalian lungs. Advances in und...
Degradation of oxidized phospholipids by lysosomal phospholipase A2 regulates pulmonary fibrosis [0.03%]
溶酶体磷脂酶A2通过降解氧化型磷脂调节肺纤维化
Doyun Kwak,Song Ling,Natalya Subbotina et al.
Doyun Kwak et al.
Recent evidence suggests that oxidized phospholipids (oxPL) play a critical role in the pathogenesis of pulmonary fibrosis. The precise mechanism by which oxPL contributes to fibrosis remains unknown and likely involves complex interactions...
Sirtuin 3 Deficiency Exacerbates Emphysema and Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease [0.03%]
沉默素3缺乏通过鼠慢性阻塞性肺疾病的模型加重肺气肿和肺部炎症
Taro Ishimori,Minako Saito,Masaaki Yuki et al.
Taro Ishimori et al.
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease caused mainly by cigarette smoke-mediated induction of oxidative stress. Sirtuin 3 (SIRT3) regulates reactive oxygen species levels, but there are no definitive repo...
Activated Factor X Inhibition Ameliorates NF-κB-IL-6‒Mediated Perivascular Inflammation and Pulmonary Hypertension [0.03%]
活化因子X抑制改善NF-κB-IL-6介导的血管周围炎症和肺动脉高压
Satomi Imakiire,Keiji Kimuro,Keimei Yoshida et al.
Satomi Imakiire et al.
Background: Activated factor X (FXa) induces inflammatory response and cell proliferation in various cell types via activation of proteinase-activated receptor-1 (PAR1) and/or PAR2. We thus aimed to investigate the impact of FXa on the deve...