Kathrine L Daniel,Chantal Gaudet,Ali Hamraghani et al.
Kathrine L Daniel et al.
Deficient nitric oxide (NO) signaling plays a critical role in the pathogenesis of bronchopulmonary dysplasia (BPD); however, clinical trials of inhaled NO (iNO) as preventive therapy for BPD have shown little to no benefit. A biochemical o...
TRAPping the effects of tobacco smoking: the regulation and function of Acp5 expression in lung macrophages [0.03%]
捕捉吸烟的影响：肺巨噬细胞中Acp5表达的调控与功能
Suzanne H Willems,Shilei Qian,Pernilla Lång et al.
Suzanne H Willems et al.
Tartrate-resistant acid phosphatase (TRAP, gene Acp5) is highly expressed in alveolar macrophages with proposed roles in lung inflammation and lung fibrosis development. We previously showed that its expression and activity are higher in lu...
Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells [0.03%]
文化条件不同地调节气管支气管基底干细胞的炎症生态位和细胞表型
Shubha Murthy,Denise A Seabold,Lalit K Gautam et al.
Shubha Murthy et al.
Bronchial epithelial cells derived from the tracheo-bronchial regions of human airways (HBECs) provide a valuable in vitro model for studying pathological mechanisms and evaluating therapeutics. This cell population comprises a mixed popula...
Epigenetic Age Acceleration in Idiopathic Pulmonary Fibrosis Revealed by DNA Methylation Clocks [0.03%]
DNA甲基化钟揭示特发性肺纤维化的表观遗传学年龄加速
Daniel B Kurbanov,Farida Ahangari,Taylor Adams et al.
Daniel B Kurbanov et al.
In this research, we delve into the association between epigenetic aging and idiopathic pulmonary fibrosis (IPF), a debilitating lung disease that progresses over time. Utilizing the Illumina MethylationEPIC array, we assessed DNA methylati...
Reflections on the Introduction of Surfactant Therapy for Neonates with Respiratory Distress [0.03%]
新生儿呼吸窘迫应用表面活性物质治疗的回顾
Fred Possmayer,Ruud Aw Veldhuizen,Alan H Jobe
Fred Possmayer
When pulmonary surfactant was first detected in the 1950s by Pattle and Clements, many thousands of infants perished each year due to a respiratory illness termed Hyaline Membrane Disease. Hyaline membranes are formed by plasma leaking thro...
β-ionone facilitates ex vivo airway smooth muscle relaxation via extraocular Opsin-3 light receptor activation [0.03%]
β-离子酮通过额外的眼外光敏蛋白Opn3受体活化促进支气管平滑肌舒张
Styvalizh Uribe,Eyar Shany,Yi Zhang et al.
Styvalizh Uribe et al.
Recent studies have linked deficiencies in β-carotene ingestion and its metabolites with an increased risk and severity of asthma exacerbations. We demonstrate that β-ionone, a β-carotene metabolite, dose-dependently relaxes upper and lo...
Characteristics, Triggers, Treatments, and Experimental Models of Neonatal Acute Respiratory Distress Syndrome [0.03%]
新生儿急性呼吸窘迫综合征的特征、诱因、治疗及实验模型
Atefeh Mohammadi,Daniele De Luca,Estelle B Gauda
Atefeh Mohammadi
Neonatal acute respiratory distress syndrome (NARDS) is a severe and potentially life-threatening form of lung injury recently defined by the International Neonatal ARDS Consensus. It is marked by extensive lung inflammation and damage to t...
Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model [0.03%]
母体摄入食用型四氢大麻酚对猕猴后代肺发育和功能影响的研究
Lyndsey E Shorey-Kendrick,B Adam Crosland,Matthias C Schabel et al.
Lyndsey E Shorey-Kendrick et al.
Prenatal cannabis use is rising, in part due to legalization and perceptions of safety. The impact of prenatal cannabis exposure on offspring development, especially respiratory health, remains largely unknown. The objective of this study w...
Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness [0.03%]
Fra-2转基因小鼠的肺血管重塑由2型炎症驱动并伴有肺血管高反应性
Anna Birnhuber,Valentina Biasin,Pritesh P Jain et al.
Anna Birnhuber et al.
Lung vessel remodeling leads to increased pulmonary vascular resistance, causing pulmonary arterial hypertension (PAH), and consequently right ventricular hypertrophy and failure. In patients suffering from systemic sclerosis (SSc), PAH can...
The Circulating Renin-Angiotensin System and Mortality among Patients Hospitalized for COVID-19: A Mechanistic Substudy of the ACTIV-4 Host Tissue Trials [0.03%]
住院COVID-19患者的循环肾素血管紧张素系统与死亡率：ACTIV-4组织定点研究中的机制性亚组研究
Christopher L Schaich,Mark C Chappell,Matthew S Shotwell et al.
Christopher L Schaich et al.
SARS-CoV-2 targets angiotensin converting enzyme-2 (ACE2), a key peptidase of the renin-angiotensin system (RAS), which regulates the balance of the vasoconstrictor/inflammatory peptide Ang II and the vasodilator/anti-inflammatory peptide A...