Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts [0.03%]
颗粒物通过增加肺成纤维细胞骨形态发生蛋白2的表达促进肌成纤维细胞分化
Nathan Craig,Jack Paul Berens,Eistine Boateng et al.
Nathan Craig et al.
Particulate matter less than 2.5 μm (PM2.5) contributes to many chronic respiratory disorders, but the mechanisms for this are not fully understood. The actions of PM2.5 on lung epithelial cells have been well studied, but their effect on ...
Roger Ming Li,Maike Stentenbach,Dino Bee Aik Tan et al.
Roger Ming Li et al.
Idiopathic pulmonary fibrosis (IPF) is a serious respiratory disease with a poor prognosis and limited treatments. IPF is characterised by accumulation of extracellular matrix, destruction of gas exchange units and decline in lung function....
Role of the Two-Pore-Domain Potassium channel TREK-1 (K2P2.1) in Hyperoxia- and Mechanical Stretch-Induced Alveolar Epithelial Injury [0.03%]
两孔钾通道TREK-1(K2P2.1)在氧中毒和机械牵张所致肺泡上皮细胞损伤中的作用
Nairrita Majumder,Benjamin Lopez,Aren Kasparian et al.
Nairrita Majumder et al.
Hyperoxia (HO) and mechanical ventilation (MV) are the mainstay of treatment for patients with acute respiratory failure, but both interventions can also accelerate further lung injury, highlighting the need for better therapeutic approache...
BALF gene expression profiling reveals a fibrosis associated innate immune activation bias in persistent post-COVID-19 ILD [0.03%]
BALF基因表达谱分析揭示了持续性新冠后ILD的与纤维化相关的先天免疫偏倚
Katerina M Katerina Antoniou,Eirini Vasarmidi,Alexandros Galaras et al.
Katerina M Katerina Antoniou et al.
Survivors of COVID-19 can experience long-term lung complications (pulmonary sequelae), but the underlying mechanisms remain unclear. While most patients with COVID-19 lung injury eventually recover essentially completely, some experience s...
Novel Murine Partial Tracheal Occlusion Model with Altered Respiratory Dynamics [0.03%]
一种具有呼吸动力学改变的新型小鼠部分气管梗阻模型
Andrea D Edwards,Elham Shahreki,Madeline K Frazier et al.
Andrea D Edwards et al.
The respiratory system is integrated to optimize efficiency. Dysfunction of one element often impacts others. For example, in COPD, both OSA and small airways dysfunction are associated with worse emphysema. In BPD, cystic lung disease and ...
Visualizing the co-development of structural and immune cells in the human fetal lung using imaging mass cytometry [0.03%]
利用成像质谱细胞技术可视化人胎儿肺部结构细胞和免疫细胞的共发育过程
Li Jia,Susana M Chuva De Sousa Lopes,Vincent van Unen et al.
Li Jia et al.
The co-development and interactions between structural and immune cells in the human fetal lung can be studied using transcriptomic and proteomic approaches. Here, we utilized imaging mass cytometry with a 31-antibody panel to visualize imm...
Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues [0.03%]
体外培养中肺间充质细胞身份的丧失及识别修复信号的筛选方法
Ana M Diaz Espinosa,Jack H Wellmerling,Natalia Del Pilar Vanegas et al.
Ana M Diaz Espinosa et al.
Lung fibroblasts generate and respond to mechanical, biochemical, and matrix cues present in their microenvironment. With the advent of next-generation sequencing technologies, multiple studies describe transcriptionally unique fibroblast s...
Respiratory syncytial virus downregulates the airway aryl hydrocarbon receptor pathway: implication for the development of a novel therapeutic target [0.03%]
呼吸道合胞病毒下调气道芳香烃受体通路：开发新型治疗靶点的启示
Aline Haas de Mello,Yue Qu,Tianshuang Liu et al.
Aline Haas de Mello et al.
Despite recent advances in preventative options, respiratory syncytial virus (RSV) infection is still a major cause of hospitalizations of young children and older adults, with no specific treatment available. The aryl hydrocarbon receptor ...
Airway smooth muscle force adaptation on the methacholine response in asthmatic patients [0.03%]
支气管哮喘患者乙酰胆碱反应中气道平滑肌张力的适应性改变
Cyndi Henry,Marie-Ève Boulay,Ariane Lechasseur et al.
Cyndi Henry et al.
A sustained contraction of the airway smooth muscle increases its contractile capacity through a time-dependent process called force adaptation, and concordantly increases the response to methacholine in healthy subjects. Whether this occur...
Use of Patient-Derived Organoids for Pleural Mesothelioma 3D modelling [0.03%]
利用患者衍生类器官进行胸膜间皮瘤的三维建模
Luca Volpini,Federica Monaco,Elisabetta Casalone et al.
Luca Volpini et al.
Defining pre-clinical models is of utmost importance for pleural mesothelioma (PM) to improve prognosis and predict therapeutic response. Using cells isolated from pleural fluid (PF) and diagnostic pleural biopsy (PB), we generated PM patie...