Conversations in Collagen: Multicellular Crosstalk Shapes the Fibrotic Niche in Pulmonary Fibrosis [0.03%]
胶原蛋白中的对话：多细胞串扰塑造特发性肺纤维化中的纤维化微环境
Rebecca J Salamon,Shally Saini
Rebecca J Salamon
Pulmonary fibrosis is often framed as a problem of excess collagen causing stiffening of the lung, but that framing misses the more dynamic reality: fibrosis is built through ongoing conversations between fibroblasts, neighboring cells, and...
Central Cholinergic Modulation of the Cough Reflex: Suppressive Effects of Donepezil in rabbits [0.03%]
胆碱能中枢镇咳效应：多奈哌齐的镇咳作用研究
Claudia Vitale,Elenia Cinelli,Alessandra Sorano et al.
Claudia Vitale et al.
Cough is a purposeful airway defensive reflex, but in chronic cough it no longer provides a clear physiological benefit and markedly impairs patient's quality of life. Currently available antitussive drugs have limited efficacy and may caus...
Efficient AI-supported quantification of network structures in SEM imaged human mucus: A detailed protocol [0.03%]
高效的人工智能支持的SEM成像人体粘液网络结构定量方法详细方案
Yannic Kerkhoff,Hanna Rulff,Paul W Mönch et al.
Yannic Kerkhoff et al.
We present a detailed protocol for the training and application of an AI-assisted workflow for automated analysis of pore and filament structures in scanning electron microscopy (SEM) images of human mucus from the respiratory tract and ile...
The role of endothelial HIF-1α in vascular and alveolar development in a neonatal murine model of Bronchopulmonary Dysplasia [0.03%]
内皮细胞HIF-1α在支气管肺发育不全新生鼠模型中血管和肺泡发育中的作用研究
Han-Pi Chang,Abiud Cantu,Manuel Eliezer Cantu Gutierrez et al.
Han-Pi Chang et al.
Bronchopulmonary dysplasia (BPD), a lung disease associated with preterm birth, is characterized by arrested alveolarization and impaired pulmonary vascular growth. Exposure to early-life hyperoxia is a disease-contributing factor, and endo...
Molecular Mechanisms Underlying FCCP-Induced Mitophagyin Human Airway Smooth Muscle Cells [0.03%]
氯苯甲酰三氟丙酮诱导的人支气管平滑肌细胞线粒体自噬的分子机制研究
Sanjana Mahadev Bhat,Oscar A Ramirez Ramirez,Gary C Sieck
Sanjana Mahadev Bhat
Mitophagy is a selective autophagic process that eliminates damaged mitochondria, which is essential for mitochondrial quality control and cellular homeostasis. The most extensively characterized mitophagy pathway involves PTEN-induced kina...
Spatiotemporal Calcium Signaling to Unlock the Calcium Paradox: Location, Location, Location! [0.03%]
时空钙信号破解钙离子悖论：位置，位置，位置！
Amir A Zeki,John G Albeck
Amir A Zeki
Larissa A Shimoda,Cristina M Alvira,Julie A Bastarache et al.
Larissa A Shimoda et al.
Opening the Black Box: Reflections from the AJP-Lung Early Career Editorial Fellows [0.03%]
打开黑箱：AJP-Lung早期职业编辑团队的反思
Stefan Hadzic,Simon J Cleary,Daniel Colon Hidalgo et al.
Stefan Hadzic et al.
Endothelial-Derived Extracellular Vesicles Impair Human Pulmonary Microvascular Cell Function in an In-Vitro Model of Sepsis-Induced Acute Lung Injury [0.03%]
内皮细胞源性外泌体通过体内模型损害脓毒症诱导的急性肺损伤中小血管细胞的功能
Maya Cohen,Liana Haigis,Rebecca Blum et al.
Maya Cohen et al.
Acute respiratory distress syndrome (ARDS) remains a critical condition associated with high morbidity and mortality, particularly when triggered by sepsis. Endothelial dysfunction is a central hallmark of ARDS pathology, but the precise me...