The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung [0.03%]
NUPR1通过协调氧化性应激和细胞代谢过程中的线粒体反应来抑制慢性阻塞性肺病发病机制中的铁死亡现象
Jessica Nouws,Saul S Siller,Tao Yang et al.
Jessica Nouws et al.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic injury and oxidative stress leading to progressive lung tissue destruction. Emerging evidence suggests that regulated cell death pathways, particularly ferroptosis, co...
Functional and biochemical characterization of Alyftrek components reveals high-potency rescue of F508del-CFTR [0.03%]
Alyftrek成分的功能和生化表征揭示了对F508del-CFTR的高效挽救作用
Sandra Mirval,Louise Damy,Auguste Sauvage-de-Gérando et al.
Sandra Mirval et al.
Alyftrek (vanzacaftor/tezacaftor/deutivacaftor, VTD) is a triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy for patients with cystic fibrosis. In this study, we characterized the pharmacological properties ...
MicroRNAs in IPF and Lung Cancer: Convergent and Divergent Mechanisms: a systematic review [0.03%]
系统综述：微小核糖核酸在IPF和肺癌中的发散与汇聚机制
Sara Gangi,Sofia Marrucci,Chiara Diana et al.
Sara Gangi et al.
Idiopathic pulmonary fibrosis (IPF) and lung cancer (LC) are distinct pathological entities; however, growing evidence indicates that they share convergent cellular and molecular mechanisms. As central post-transcriptional regulators microR...
Mechanical and Chemical Power and Mortality in Acute Respiratory Distress Syndrome: An Exploratory Analysis of Six Patient Cohorts [0.03%]
急性呼吸窘迫综合征患者机械通气与化学镇静的强度和死亡率：六项队列研究的探索性分析
Thijs A Lilien,Lieuwe D J Bos,Lukas Martin Mueller-Wirtz et al.
Thijs A Lilien et al.
Invasive ventilation with oxygen supplementation may inadvertently cause ventilator- and hyperoxia-induced lung injury, respectively, but their balance is fairly unaddressed. The concept of mechanical power summarizes factors of ventilation...
Testosterone alleviates inflammation but increases the methacholine response in male mice with allergic lung inflammation [0.03%]
睾酮通过减轻炎症但增加过敏性肺炎小鼠的乙酰甲胆碱反应来缓解哮喘症状
Cyndi Henry,Magali Boucher,Andrés Rojas-Ruiz et al.
Cyndi Henry et al.
Testosterone seems protective against asthma, but the underlying mechanisms are uncertain. Although several of its anti-inflammatory properties have been described, its effect on respiratory mechanics and the methacholine response are incom...
Conversations in Collagen: Multicellular Crosstalk Shapes the Fibrotic Niche in Pulmonary Fibrosis [0.03%]
胶原蛋白中的对话：多细胞串扰塑造特发性肺纤维化中的纤维化微环境
Rebecca J Salamon,Shally Saini
Rebecca J Salamon
Pulmonary fibrosis is often framed as a problem of excess collagen causing stiffening of the lung, but that framing misses the more dynamic reality: fibrosis is built through ongoing conversations between fibroblasts, neighboring cells, and...
Central Cholinergic Modulation of the Cough Reflex: Suppressive Effects of Donepezil in rabbits [0.03%]
胆碱能中枢镇咳效应：多奈哌齐的镇咳作用研究
Claudia Vitale,Elenia Cinelli,Alessandra Sorano et al.
Claudia Vitale et al.
Cough is a purposeful airway defensive reflex, but in chronic cough it no longer provides a clear physiological benefit and markedly impairs patient's quality of life. Currently available antitussive drugs have limited efficacy and may caus...
Efficient AI-supported quantification of network structures in SEM imaged human mucus: A detailed protocol [0.03%]
高效的人工智能支持的SEM成像人体粘液网络结构定量方法详细方案
Yannic Kerkhoff,Hanna Rulff,Paul W Mönch et al.
Yannic Kerkhoff et al.
We present a detailed protocol for the training and application of an AI-assisted workflow for automated analysis of pore and filament structures in scanning electron microscopy (SEM) images of human mucus from the respiratory tract and ile...
The role of endothelial HIF-1α in vascular and alveolar development in a neonatal murine model of Bronchopulmonary Dysplasia [0.03%]
内皮细胞HIF-1α在支气管肺发育不全新生鼠模型中血管和肺泡发育中的作用研究
Han-Pi Chang,Abiud Cantu,Manuel Eliezer Cantu Gutierrez et al.
Han-Pi Chang et al.
Bronchopulmonary dysplasia (BPD), a lung disease associated with preterm birth, is characterized by arrested alveolarization and impaired pulmonary vascular growth. Exposure to early-life hyperoxia is a disease-contributing factor, and endo...