Endogenous oxalate synthesis in mouse models of metabolic dysfunction-associated steatotic liver disease [0.03%]
Xingsheng Li,Owen P Cunneely,Jeremy B Foote et al.
Xingsheng Li et al.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) may lead to increased urinary oxalate excretion, a risk factor for calcium oxalate kidney stone formation, and progression of chronic kidney disease. We used mouse ...
Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents [0.03%]
Edwin J Baldelomar,Jennifer R Charlton,Shella Keilhoz et al.
Edwin J Baldelomar et al.
We investigated whether physiological oscillations detected by non-contrast resting-state magnetic resonance imaging(rsMRI) can be used to measure functional nephron number, nephron density, or estimated single-nephron glomerular filtration...
Gustavo Frindt,Theresa Rohan,Ryan Schreiner et al.
Gustavo Frindt et al.
We studied the control of processing of the epithelial Na+ channel (ENaC) through acute dietary Na loading and anti-diuretic hormone. Acute salt-repletion of Na-depleted rats decreased the abundance of fully processed ENaC proteins, assesse...
Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins [0.03%]
Isadore Budnick,Amy Argabright,Colin C Anderson et al.
Isadore Budnick et al.
Pre-renal azotemia (PRA) accounts for 10-30% of hospitalized cases of acute kidney injury (AKI). In contrast to AKI from acute tubular injury (ATI), PRA is considered a benign condition, despite evidence that it is associated with adverse c...
Pamela K Carmines,Edward W Inscho
Pamela K Carmines
HIF-mediated regulation of glutathione-specific gamma-glutamyl cyclotransferase 1 contributes to tubular cell death in renal ischemia-reperfusion [0.03%]
Yoshitaka Kihira,Takujiro Homma,Shinji Matsunaga et al.
Yoshitaka Kihira et al.
Renal ischemia-reperfusion (I/R) remains a leading cause of acute renal failure in both native and transplanted kidneys. Hypoxia-inducible factor (HIF)-1α is a protective factor against renal I/R injury (rIRI). However, the downstream mech...
The urine metabolomic signature of distal diuretics and diuretic-induced hyponatremia in patients with chronic kidney disease [0.03%]
慢性肾脏病患者远端利尿剂的尿代谢标志物及利尿剂所致低钠血症的尿代谢标志物
Crissy F Rudolphi,Usha Musterd-Bhaggoe,George J G Ruijter et al.
Crissy F Rudolphi et al.
Recent clinical trials have shown that distal nephron-acting diuretics are effective in managing fluid retention and salt-sensitive hypertension in people with chronic kidney disease (CKD). However, their use may be complicated by diuretic-...
Peak Oxygen Consumption is Positively Associated with Estimates of Oxygen Extraction and Microvascular Blood Volume in Veterans with Chronic Kidney Disease [0.03%]
慢性肾脏病患者峰值耗氧量与氧气摄取估计值和微血管血容量之间的正相关性研究
Jared M Gollie,Peter Kokkinos,Samir S Patel et al.
Jared M Gollie et al.
Peak oxygen consumption (V̇O2peak) is reduced in patients with chronic kidney disease (CKD). Although cardiovascular and skeletal muscle factors are implicated in the declines of VO2peak, few studies have evaluated muscle oxygenation respo...
Lawrence G Palmer,Alan M Weinstein,Gustavo Frindt
Lawrence G Palmer
Among the many impressive feats of the kidney is the ability to conserve Na+. When intake of Na+ through the diet is very low, urine Na+ concentrations can fall to sub-millimolar levels. This enables the preservation of extracellular fluid ...
GPR183 contributes to renal macrophage infiltration and fibrosis in kidney injury [0.03%]
GPR183参与肾损伤中的肾巨噬细胞浸润和纤维化
Qian Zhang,Yan Wang,Yu Fan et al.
Qian Zhang et al.
Macrophages play a key role in kidney inflammation and fibrosis. The oxysterol receptor G protein-coupled receptor 183 (GPR183) is an important immunomodulatory receptor, but its role in kidney disease is undefined. In this study, we invest...