Michael J Clague,Igor Barsukov,Judy M Coulson et al.
Michael J Clague et al.
Ubiquitylation is a major posttranslational modification that controls most complex aspects of cell physiology. It is reversed through the action of a large family of deubiquitylating enzymes (DUBs) that are emerging as attractive therapeut...
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding [0.03%]
脓毒症：多系统异常、异质性反应和对疾病认识的不断更新
Kendra N Iskander,Marcin F Osuchowski,Deborah J Stearns-Kurosawa et al.
Kendra N Iskander et al.
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes substantial human morbidity resulting in hundreds of thousands of deaths each year. Despite decades of intense research, the basic mechanisms still...
Fabrizio Benedetti
Fabrizio Benedetti
Modern medicine has progressed in parallel with the advancement of biochemistry, anatomy, and physiology. By using the tools of modern medicine, the physician today can treat and prevent a number of diseases through pharmacology, genetics, ...
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action [0.03%]
11β-羟类固醇脱氢酶：调节组织内糖皮质激素作用的“守门人”
Karen Chapman,Megan Holmes,Jonathan Seckl
Karen Chapman
Glucocorticoid action on target tissues is determined by the density of "nuclear" receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyze interconversion of active cortisol a...
Tamas Balla
Tamas Balla
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they control almost all aspects of a cell's life and death. These lipids gained tremendous research interest as plasma membrane signaling molecules when di...
Erik A Richter,Mark Hargreaves
Erik A Richter
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose transporter which translocates from intracellular sto...
Eunji Cheong,Hee-Sup Shin
Eunji Cheong
Low-voltage-activated T-type Ca(2+) channels are widely expressed in various types of neurons. Once deinactivated by hyperpolarization, T-type channels are ready to be activated by a small depolarization near the resting membrane potential ...
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters [0.03%]
钠耦联碳酸氢盐转运蛋白的分歧、作用、角色和家族成员关系
Mark D Parker,Walter F Boron
Mark D Parker
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two oth...
Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications [0.03%]
毒液毒素与生物离子通道结合的计算研究方法：理论与应用
Dan Gordon,Rong Chen,Shin-Ho Chung
Dan Gordon
The discovery of new drugs that selectively block or modulate ion channels has great potential to provide new treatments for a host of conditions. One promising avenue revolves around modifying or mimicking certain naturally occurring ion c...
Björn Rasch,Jan Born
Björn Rasch
Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on conc...