Antonio Rodríguez-Moreno,Ole Paulsen
Antonio Rodríguez-Moreno
One of the most remarkable properties of the mammalian brain is its ability to change in response to experience, a phenomenon referred to as neural plasticity. Synaptic plasticity specifically refers to activity-dependent changes in synapti...
Catecholamine metabolism revisited: From neurochemistry to integrative physiology and pathophysiology [0.03%]
多巴胺代谢的再思考：从神经化学到整合生理学和病理生理学
David S Goldstein,Graeme Eisenhofer
David S Goldstein
After a previous overview published more than 20 years ago, key aspects of catecholamine metabolism remain incompletely understood by physiologists. Meanwhile, the repertoire of assayable catecholamine-related compounds has expanded. Moreov...
THE ORIGINS AND PROGRESSION OF PYLORIC METAPLASIA FOLLOWING GASTRIC MUCOSAL INJURY [0.03%]
胃黏膜损伤后幽门化生的起源和进展过程
Sophia K Cornish,Eunyoung Choi,Jason C Mills et al.
Sophia K Cornish et al.
The human gastric mucosa contends with insults throughout the course of its normal functions. Superficial injuries are rapidly resolved by the normal cellular lineages within the glandular epithelium. Deeper injuries often cause loss of aci...
AKAP Signaling: physiological and pathophysiological role and opportunities for novel therapeutic concepts [0.03%]
AKAP信号转导：生理和病理生理作用以及新的治疗概念机会
Friedrich W Herberg,Ester Paolocci,Enno Klussmann
Friedrich W Herberg
A-kinase anchoring proteins (AKAPs) received their name based on their ability to bind protein kinase A (PKA). Now, AKAPs have grown to a diverse family of more than 50 proteins, coordinating molecules far beyond PKA and the PKA signaling p...
Marcello Massimini,Angel V Peterchev,Andreas Vlachos et al.
Marcello Massimini et al.
Transcranial magnetic stimulation (TMS) non-invasively activates the human cortex through the intact skull and is now employed worldwide to interrogate physiological and pathological functions of the human brain, and to treat a variety of n...
Ravinder K Mittal,Yifeng Bu,Nick J Spencer
Ravinder K Mittal
Mechanism of esophageal peristalsis or sequential contractions of the skeletal and smooth muscle esophagus resides at multiple levels, i.e., brain stem (central pattern generator), neurons within the wall of the esophagus (myenteric plexus)...
Impact of gastric emptying and small intestinal carbohydrate absorption on glycemia in health and diabetes: therapeutic implications [0.03%]
胃排空和小肠碳水化合物吸收对健康与糖尿病患者血糖的影响及其治疗意义
Ryan J Jalleh,Tongzhi Wu,Mahesh M Umapathysivam et al.
Ryan J Jalleh et al.
Gastric emptying, which exhibits a substantial inter-, but much lesser intraindividual, variation in health and is frequently disordered (particularly delayed) in diabetes, is now appreciated to be a major determinant of postprandial glycem...
Temugin Berta,Arkady Khoutorsky,Jing Xu et al.
Temugin Berta et al.
Neuropathic pain is a chronic, debilitating condition that affects approximately 78% of the global population and remains difficult to treat due to limited therapeutic options. Over the past two decades, mounting preclinical evidence has hi...
Transitional Cell States at the Crossroad of Development, Disease, and Repair-Regeneration [0.03%]
发育、疾病与修复再生交叉点的过渡细胞状态
Xiangyi Ke,Wellington V Cardoso
Xiangyi Ke
Cells undergoing transitional states have been broadly referred to as plastic intermediates emerging between stable identities in multiple biological contexts. Once regarded as indistinct midpoints on lineage trajectories, these states are ...