11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
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Glucocorticoid action on target tissues is determined by the density of "nuclear" receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyze interconversion of active cortisol and corticosterone wi... ...
