FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization [0.03%]
FAM83H通过胸腺基质组织调控产后T细胞发育
Betul Melike Ogan,Veronika Forstlova,Laura Jane Dowling et al.
Betul Melike Ogan et al.
Family of Sequence Similarity 83H (FAM83H/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein kinase 1 (CK1) and keratins to regulate cytoskeletal organization, cell proliferation, and vesicular trafficking. M...
Shared HLA-E and Mamu-E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF- and Fluorescence Polarisation-Based Methods [0.03%]
结合nDSF和荧光偏振基方法揭示共享的HLA-E和Mamu-E肽配体库及其细微的多态性效应
Max N Quastel,Sashini A Ranawana,Bas W A Peeters et al.
Max N Quastel et al.
The primary function of MHC-E-human leukocyte antigen (HLA)-E in humans and Mamu-E in rhesus macaques-relates to immune surveillance via CD94/NKG2x receptors expressed on NK cells. However, a secondary role where MHC-E presents immunogenic ...
The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells [0.03%]
肥胖和衰老中观察到的乳酸分泌增加导致生成病理性B细胞
Maria Romero,Amanda Virtue,Kate Miller et al.
Maria Romero et al.
Lactate is a metabolite with immunoregulatory functions. We evaluated lactate secretion and its effects on B cells from individuals with different body composition: YLEAN, YOBESE, and ELEAN individuals. Results show higher serum metabolic p...
A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts [0.03%]
人类扁桃体结构的转录图谱：超越单细胞之和的部分组合
Helena L Crowell,Laura Llaó-Cid,Gerard Frigola et al.
Helena L Crowell et al.
The tonsil is a highly compartmentalized organ in which different microanatomical structures orchestrate designated (immune) functions. We use this already well-studied tissue to survey imaging-based spatial transcriptomics data for studyin...
SARS-CoV-2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults [0.03%]
新冠病毒mRNA疫苗接种诱导成人出现短暂的体液和B细胞旁观者免疫反应
Lisan H Kuijper,Laura Y L Kummer,Laura Fernandez Blanco et al.
Lisan H Kuijper et al.
After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating antibodies. In addition, memory B cells (MBC) are quickly reactivated upon antigen re-exposure and predominantly generate shorter-lived ASC...
Megan M Hanlon,Ursula Fearon,Ellen M Gravallese
Megan M Hanlon
Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a heterogeneous population of subsets. Despite the crucial role of these cells in disease, the relative contribution of specific ...
Thrombospondin-1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells [0.03%]
缝隙连接传感器触发T细胞和血小板粘附及调节T细胞二维和三维运动的差异性表达
Karl-Gösta Sundqvist
Karl-Gösta Sundqvist
The regulation of cell adhesion and motility is poorly understood. The present study uncovers a mechanism by which cells sense the microenvironment and regulate adhesion and motility. The C-terminal of TSP-1 was found to sense cell contact,...
Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation [0.03%]
分隔的肌肉和大脑局部区域的空间解析配置 profilling
Thorge Dobbertin,Lucas Schirmer
Thorge Dobbertin
Spatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal cells interact in situ during inflammation. Chronic inflamm...