Development of Indolo-Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes [0.03%]
通过生物烷基自由基吲哚化反应合成咔唑异构体(indolo-bicyclo[3.1.1]heptane)
Yuan Liu,Jun-Yunzi Wu,Shuang Lin et al.
Yuan Liu et al.
Semisaturated ring systems with a balanced fraction of C(sp3) have garnered increasing attention in drug development. In this study, we propose indolo-bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for ...
Reversible Mechanical Interlocking via Stimuli-Triggered Nonhomeomorphic Topology Transformation Enables Highly Efficient Rotaxane Synthesis [0.03%]
刺激触发非同胚拓扑转化实现轮烷高效合成及机械互锁的可逆性研究
Chunlin Xiao,Xue Li,Naohiro Okamoto et al.
Chunlin Xiao et al.
Rotaxanes, as one of the most fundamental mechanically interlocked molecules (MIMs), have attracted considerable attention in many fields. However, a method that reconciles convenient, efficient, and "high-value-added" (such as reversibilit...
Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron-Deficient Aromatic d-Amino Acids [0.03%]
通过苯丙氨酸氨酶合成缺电子芳香族d型氨基酸实现旋光选择性转换
Ivan Buslov,Sarah Desmons,Weijin Wang et al.
Ivan Buslov et al.
Aromatic d-amino acids (d-AAs) are valuable building blocks in drug discovery and peptide therapeutics, yet their direct and efficient biocatalytic synthesis remains a challenge. Here, we report the rational engineering of phenylalanine amm...
Chenyang Hu,Álvaro García-Romero,Debanik Ray et al.
Chenyang Hu et al.
The synthesis and isolation of a phosphorus(III) telluride is reported. The compound was accessed by means of a double bond metathesis reaction between an amido-functionalized phosphinidene oxide, BnArNP═O (Ar = bulky aryl substituent), wi...
Self-Assembled Nanoconjugates with Aggregation-Induced Emission for Near-Infrared II Imaging and Transcytosis-Driven Cancer Therapy [0.03%]
自组装聚集诱导发光近红外二区纳米偶联物用于跨细胞转运驱动的癌症治疗
Guiping Yuan,Wutong Du,Feiyi Sun et al.
Guiping Yuan et al.
Nanomedicine holds immense potential to revolutionize cancer therapy, yet its clinical translation remains hampered by insufficient tumor accumulation and an inability to dynamically monitor therapeutic penetration. While transcytosis-media...
Probing the Structural Dynamics of In2O3 Using in Situ Raman Spectroscopy: Bridging Material Dynamics and Sensor Functionality [0.03%]
原位拉曼光谱探测In2O3的结构动力学：从材料动态到传感器功能机制的研究
Na Zhao,Xiao Chang,Xianghong Liu et al.
Na Zhao et al.
Metal oxide semiconductor (MOS) gas sensors still face the critical challenge of high operating temperatures. While material engineering strategies have enabled room-temperature operation, the dynamic evolution of active phases during sensi...
Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide [0.03%]
电化学衍生活性过氧化物引导乙腈中的酰胺合成
Ling-Yu Dong,Yu-Tai Wu,Yi-Fan Wang et al.
Ling-Yu Dong et al.
Amides with unique carbonyl-nitrogen linkage are fundamental functional groups that are active and essential for a wide range of natural and synthetic products, pharmaceuticals, agrochemicals, and key intermediates. Amide bond formation is ...
Strengthening Intermediate Adsorption on a Cobalt Phthalocyanine Assembly by Polymeric Modification for Electrochemical Carbon Dioxide Reduction into Methanol [0.03%]
聚合作用增强钴酞菁电化学二氧化碳还原为甲醇的中间态吸附作用
Poe Ei Phyu Win,Xin Xu,Lilong Zhang et al.
Poe Ei Phyu Win et al.
Electrochemical carbon dioxide reduction (CO2R) to generate value added methanol (MeOH) in water has been considered as a potential strategy to realize efficient carbon cycle and reutilization. Cobalt phthalocyanine (CoPc) represents as a c...
Ahmed M. El-Zohry [0.03%]
艾哈迈德·M·埃尔-佐赫里
Ahmed M El-Zohry
Ahmed M El-Zohry
"The most rewarding part of my job is receiving a dose of dopamine upon the acceptance of my papers… In retrospect, groundbreaking discoveries frequently originate from simple ideas rather than complex ones…" Find out more about Ahmed M. ...
In Situ Orthogonal Chemistry for Facile Preparation of Uniform COF-Based Composite Polymer Electrolytes [0.03%]
原位正交化学在制备均匀的共价有机框架基复合聚合物电解质中的应用
Junchen Meng,Mengjia Yin,Fen Li et al.
Junchen Meng et al.
Covalent organic framework (COF)-based composite polymer electrolytes (CPEs) represent a promising platform for advanced lithium-metal batteries (LMBs) with high energy density. However, conventional physical fabrication methods may suffer ...