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Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron-Deficient Aromatic d-Amino Acids

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Aromatic d-amino acids (d-AAs) are valuable building blocks in drug discovery and peptide therapeutics, yet their direct and efficient biocatalytic synthesis remains a challenge. Here, we report the rational engineering of phenylalanine ammonia lyase from Plan... ...