Re-evaluating Stem Cell Roles in Homeostasis and Cancer of the Esophagus [0.03%]
食管稳态和肿瘤发生中干细胞作用的再评估
Lana Kostic,Nick Barker
Lana Kostic
The localization and identity of esophageal stem cells remain highly debated, prompting the emergence of several hypotheses. Although early models proposed a homogeneous basal progenitor layer, recent evidence suggests a heterogeneous pool ...
Butyrate, IL-4, and EP4 Receptors: A Triad of Colorectal Homeostasis, Protecting Against Onset of Cancer and IBD? [0.03%]
丁酸盐、IL-4和EP4受体：一种结直肠稳态的三联保护因素，防止癌症和IBD的发生？
Hiromichi Fujino
Hiromichi Fujino
In this article, onset mechanisms of colorectal cancer and intestinal bowel diseases (IBD) are postulated to involve the aberrant expression/hyper-activation of E-type prostanoid 4 (EP4) receptors. Although prostaglandin E2 and EP4 receptor...
Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation: A critical analysis of "Active control of mitochondrial network morphology by metabolism-driven redox state" by Singh et al. and studies replacing ETC components with yeast counterparts [0.03%]
代谢底物、进入线粒体电子链的位点以及活性氧生成之间的复杂相互作用：对Singh等人的“由代谢驱动的氧化还原状态主动控制线粒体网络形态”的批判性分析及用酵母同类替换电子传递链成分的研究
Dave Speijer
Dave Speijer
Recently, a fascinating, well-executed, molecular study regarding the direct influence of mitochondrial reactive oxygen species (ROS) formation by the electron transport chain (ETC) on mitochondrial morphology in baker's yeast appeared in P...
Chaitali Chakraborty,Itzel Nissen,Silvia Remeseiro
Chaitali Chakraborty
Neuron-glioma interactions are critical drivers of glioma progression, with neuronal activity promoting tumor growth and invasion through paracrine signaling and direct synaptic input. Beyond well-established glutamatergic synapses, recent ...
Glymphatic Transport as a Possible New Mechanism for the Long-Range Signaling of Extracellular Vesicles Through the CNS [0.03%]
脑脊液循环驱动细胞外囊泡长距离运输及信号转导的新机制
Agnė Pociūtė,Augustas Pivoriūnas
Agnė Pociūtė
Extracellular vesicles (EVs) are secreted by all types of cells in the central nervous system (CNS) and participate in intercellular communication in physiological and pathological settings. However, an emerging view of multidirectional com...
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection [0.03%]
成人神经发生的减少是由于权衡而不是直接的负面选择的结果
David Morizet,Laure Bally-Cuif
David Morizet
The reduction of adult neurogenesis in the human brain, compared to other vertebrate species, has been proposed to result from an active counter-selection to permit the stability of circuits needed for long-term memorization and higher cogn...
Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases [0.03%]
淀粉样蛋白Aβ的变色龙特性对其它淀粉样蛋白疾病的含义及其对阿尔茨海默病的影响
Birgit Strodel
Birgit Strodel
The amyloid-β peptide (Aβ), implicated in Alzheimer's disease, exhibits significant polymorphism. At the monomer level, Aβ can adopt disordered, helical, and β-hairpin structures, influenced by environmental conditions. Both oligomeric ...
New Energy Frontier for Regeneration: Non-Mitochondrial Pathways Fueling Injury-Induced Axonal Regrowth [0.03%]
神经再生的新能量前沿：非线粒体代谢通路促进损伤诱导的轴突再生生长
Luca Masin,Anyi Zhang,Steven Bergmans et al.
Luca Masin et al.
The ability of the mammalian central nervous system (CNS) to regenerate its damaged axons is limited, in part because of its inability to muster the required energy production machinery to the axon to support the regrowth. Although mitochon...
Henver S Brunetta,Marcelo A Mori,Alexander Bartelt
Henver S Brunetta
Mitochondrial membrane potential is highly dependent on coupled as well as uncoupled respiration. While brown adipose tissue (BAT) mediates non-shivering thermogenesis (NST), a highly adaptive bioenergetic process critical for energy metabo...