Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases
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The amyloid-β peptide (Aβ), implicated in Alzheimer's disease, exhibits significant polymorphism. At the monomer level, Aβ can adopt disordered, helical, and β-hairpin structures, influenced by environmental conditions. Both oligomeric and fibrillar state... ...