Beyond Multilevel Selection in Cancer: Rethinking Metastasis Through Selection for Function [0.03%]
超越癌症中的多级选择：通过功能选择重新思考转移性癌
Frédéric Thomas,Antoine M Dujon
Frédéric Thomas
Laplane et al. recently provided a valuable framework for understanding cancer evolution through multilevel selection (MLS), distinguishing between MLS1, where groups differ in persistence based on the traits of their constituent cells but ...
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division [0.03%]
何时、何地、如何？整合细胞分裂中的时空线索
Luca Cirillo,Hradini Konthalapalli,Claudio Alfieri et al.
Luca Cirillo et al.
To an external observer, the goal of cell division is evident from the very shape of the duplicated chromosomes. Cells, however, cannot see-they must proceed by groping in the dark, searching for their own DNA-and a series of sophisticated ...
J Paul Robinson,Grzegorz B Gmyrek,Bartek Rajwa
J Paul Robinson
Flow cytometry is a versatile analytical technology for measuring physical and molecular characteristics of individual cells or particles in suspension. The technology has had its greatest impact in immunology, enabling the identification a...
The Double Face of Base Excision Repair: Preventing and Triggering Double-Strand Breaks [0.03%]
基 excision 修复的双重作用：预防和触发双链断裂
Susan M Gasser
Susan M Gasser
How cells repair oxidative damage to DNA has been studied for over 60 years. Recent evidence confirms that the base excision repair (BER) machinery not only acts to restore an intact double DNA helix by replacing oxidized bases, but under s...
Nario Tomishige,Yves Mély,Toshihide Kobayashi
Nario Tomishige
Human immunodeficiency virus type 1 (HIV-1) possesses an envelope enriched with a specific set of host plasma membrane (PM) lipids, a composition that is critical for viral infectivity. Virus budding is initiated by the binding of the viral...
Jaroslav Kalous,Fatima J Berro,Lucie Nemcova
Jaroslav Kalous
The protein kinase C (PKC) family comprises enzyme kinases that regulate cell survival, metabolism, and proliferation. PKC isotypes (PKCs) phosphorylate specific downstream substrates, thereby controlling critical steps in both mitotic and ...
Hypothesis: Ephrin-Eph Signaling Pathways Provide Novel Targets for Accelerated Re-Epithelialization of Cutaneous Wounds [0.03%]
假说：Ephrin-Eph信号通路可作为促进皮肤伤口再上皮化的新型靶标
Rodolfo D Vicetti Miguel,Mohan Liu,Gabriel J Campion et al.
Rodolfo D Vicetti Miguel et al.
Cutaneous wound repair is tightly regulated by numerous signaling pathways that coordinate a multiphased response. The repair process includes a proliferative phase that forms granulation tissue at the wound base and re-epithelialization of...
Ultra-Conserved Poison Exons Enable Rapid and Safe Splicing Factor Gene Expression Switches: A Hypothesis [0.03%]
超保守毒 exon 使剪接因子基因表达切换快速且安全：一种假说
Caroline Dalgliesh,Farimah Ghorbani,Adam J M Wollman et al.
Caroline Dalgliesh et al.
Most vertebrate genes are split up into exons and introns, with exons being spliced together to make mRNA. Many of the proteins involved in splicing, called splicing factors, exert concentration-dependent effects on gene expression through ...
Dave Speijer
Dave Speijer
IL-12 and the Antitumor Response: The Good, the Bad, and the Unknown [0.03%]
关于IL-12和抗肿瘤反应：益处、风险及未知领域
Olivier Fesneau,Thomas Duhen
Olivier Fesneau
IL-12 is a proinflammatory cytokine secreted by antigen-presenting cells. It promotes the differentiation of cytotoxic T cells, which makes it a strong candidate to boost the antitumor immune response in cancer patients. While its first use...