Why a Chloroplast Needs Its Own Genome Tethered to the Thylakoid Membrane-Co-Location for Redox Regulation [0.03%]
为什么叶绿体需要自己的基因组附着在类囊体膜上—兼论共定位的氧化还原调节作用
John F Allen
John F Allen
A chloroplast is a subcellular organelle of photosynthesis in plant and algal cells. A chloroplast's genome encodes proteins of the photosynthetic electron transport chain along with proteins required to express them. Chloroplast-encoded ph...
Condensates on the Move: Midbody Remnants as Large, Translation-Competent Extracellular Vesicles [0.03%]
迁移的凝集物：细胞间残体作为大的、可进行翻译的细胞间囊泡
Ahna R Skop
Ahna R Skop
Recent work has expanded understanding of extracellular vesicle (EV) biology by identifying midbody remnants (MBRs) as large, translationally competent vesicles released during mitosis. MBRs contain ribosomes, mitochondria, translation fact...
Unique/Rapid Feedback Mechanisms of PGD2 and PGE2 as Local/Short-Lived Autacoids; Implications of Biased Activities by Their Metabolites [0.03%]
PGD2和PGE2作为局部作用且半衰期短暂的自体活性物质的独特/快速反馈机制；其代谢产物偏效活动的意义
Hiromichi Fujino,Keijo Fukushima
Hiromichi Fujino
Prostanoids are involved in various physiological/pathophysiological functions, such as inflammation. Since persistent inflammation may cause chronic symptoms, their activation is very short and needs to be properly terminated. Due to struc...
Engineering CAR-Tregs with Phage-Selected scFv Enables a New Paradigm for Immune Regulation [0.03%]
噬菌体选择单链抗体工程CAR-Treg细胞开启新的免疫调控范式
Fatih Noyan,Matthias Hardtke-Wolenski
Fatih Noyan
Regulatory T cells (Tregs) are central to immune tolerance, yet antigen-specific cell therapies lag behind cytotoxic CAR-T approaches. Most CAR-Treg programs still use single-chain variable fragments (scFvs) derived from monoclonal antibodi...
Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity [0.03%]
分子杂技演员：CHD重塑因子如何改造基因遗传背景以赋予细胞身份许可
İsa Özdemir,Sarah J Hainer
İsa Özdemir
In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 meters of DNA into a microscopic nucleus, it ...
Thomas A Leonard
Thomas A Leonard
PH domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/PHLPP2) have, for more than 20 years, been described as Akt phosphatases and tumor suppressor genes. Approximately 200 PubMed-indexed articles have been published on the top...
Peyman Fahimi,Michael Lynch,Chérif F Matta
Peyman Fahimi
In a 2018 paper and a subsequent article published in 2023, researchers reported that mitochondria maintain temperatures 10°C-15°C higher than the surrounding cytoplasm-a finding that deviates by five to six orders of magnitude from theor...
From the Selfish Gene to the "We": Cooperation Often Needs Suppressors [0.03%]
从自私的基因到"我们": 合作通常需要抑制因素
Michel Salzet
Michel Salzet
Human cooperation is often explained through motivations and values, but it is also a strategic and evolutionary problem: locally advantageous behavior can erode the collective arrangements on which everyone depends. Dawkins' gene-centered ...
Hina Sultana,Sabyasachi Mohanty,Abhishikt David Solomon et al.
Hina Sultana et al.
Artificial intelligence (AI) strategies are revolutionizing genomics by extracting complex patterns that traditional statistical pipelines are likely to miss. This mini-review aims to provide a concise overview of how AI is transforming maj...
Rethinking One Health: Microbial Foundations for Ecological Governance [0.03%]
重塑“同一健康”理念：生态治理的微生物基础
Andrea Fernandez Diaz,Frédéric Keck,Melissa K Melby et al.
Andrea Fernandez Diaz et al.
The One Health (OH) framework has gained prominence in recent years, promoting an approach integrating the health of humans, animals, and the environment. However, its implementation as it pertains to the microbial world has largely priorit...