Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives [0.03%]
基于纳米医学的癌症免疫疗法：转化障碍、机制策略和未来展望
Xiaoman Suo,Yingnan Liu,Guofang Zhang et al.
Xiaoman Suo et al.
Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the efficacy and safety of cancer treatment. Despite substantial preclinical potential, clinical tra...
Lysosome-directed targeted protein degradation technologies for overcoming cancer drug resistance: mechanisms, design principles, and therapeutic opportunities [0.03%]
溶酶体靶向诱导蛋白降解技术克服癌症药物耐药性：机制、设计原理与治疗机会
Huixin Mao,Ying Zhang,Mingqi Liu et al.
Huixin Mao et al.
Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy to address cancer drug resistance by enabling the selective and efficient degradation of disease-associated proteins through cellular mechanisms. Since 2020,...
Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation [0.03%]
一种自组装非甾体抗炎药肽水凝胶有效缓解眼内炎症
Yuhan Hu,Yu Li,Yuqin Wu et al.
Yuhan Hu et al.
Pranoprofen (Pra) eye drop has been widely used in clinical practice for the efficient mitigation of ocular inflammation, but it often suffers from poor bioavailability owing to the existence of various ocular barriers (i.e. tear barrier an...
FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery [0.03%]
基于FEA的微气泡针的设计及针尖可控分离以实现快速透皮和黏膜给药
Changzhao Jiang,Jing Yang,Mengxuan Gao et al.
Changzhao Jiang et al.
Separable bubble microneedles (BMNs) incorporate an internal cavity that enables tip-confined loading and controlled tip-baseplate separation, yet their design has largely relied on empirical iteration. Here, we present a finite element ana...
Liposome-mediated delivery of a ruthenium-based metallodrug to overcome cisplatin resistance in osteosarcoma [0.03%]
脂质体介导的钌基金属药物输送以克服骨肉瘤中顺铂耐药性
Dzohara Murillo,Elena Domínguez-Jurado,Carmen Huergo et al.
Dzohara Murillo et al.
The treatment of osteosarcoma has remained largely unchanged over the past decades. Its low incidence, predominantly affecting children and young adults, combined with marked biological heterogeneity, poses major challenges to the developme...
Exploiting the dynamics of hyperthermia-enhanced delivery of thermosensitive liposomal doxorubicin to solid tumors [0.03%]
利用肿瘤高温增强的热敏脂质体多柔比星给药动力学效应治疗实体瘤研究
Pouya Namakshenas,Johannes Crezee,H Petra Kok
Pouya Namakshenas
Thermosensitive liposomal (TSL) drug delivery with intravascular release under hyperthermia is a promising approach for chemotherapy of solid tumors, where the hyperthermia schedule strongly influences delivery efficacy. This study uses mat...
Gallic acid-driven core-shell nanovehicles enable intestinal adhesion and adipose retention for enhanced oral bioavailability of cholecalciferol [0.03%]
没药酸驱动的核壳纳米载体增强胆钙化醇口服生物利用度及其在肠道内的黏附和在脂肪组织中的滞留性能研究
Guangyu Fan,Jixiang Zhao,Ru Zhang et al.
Guangyu Fan et al.
Cholecalciferol (VDC), a vital form of vitamin D, is essential for maintaining calcium-phosphorus balance, promoting bone health, and regulating the immune system; however, its therapeutic potential is limited by low oral bioavailability an...
Targeted proteoform degradation for precision drug design, delivery, and therapy [0.03%]
靶向蛋白质降解实现药物设计、递送和治疗的精准性
Chenyu Cui,Haoyue Zhang,Xinmiao Wang et al.
Chenyu Cui et al.
Ubiquitin-proteasome system (UPS)-mediated targeted protein degradation (TPD) is a central mechanism of maintaining protein homeostasis, which is closely associated with multiple diseases. Proteolysis-targeting chimeras (PROTACs) represent ...
Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice [0.03%]
用于治疗小鼠美国皮肤利什曼病的Microneedle递送Fungizone/两性霉素B疗法
Ryan H Huston,Blake Cox,Chaitenya Verma et al.
Ryan H Huston et al.
Amphotericin B (AmB) is a potent, accessible, FDA-approved drug against CL with damaging side effects. While newer lipid formulations have less toxicity, limitations include affordability and cold-chain requirements. CL affects mostly impov...
Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review [0.03%]
硫酸钠以外的耳保护药物的局部应用预防顺铂引起的听力损失：系统评价
Amirhossein Masroor,Nienke Streefkerk,Martine Van Grotel et al.
Amirhossein Masroor et al.
Cisplatin-induced hearing loss (CIHL) in pediatric cancer patients is an irreversible and highly prevalent adverse effect with a devastating impact on quality of life. Sodium thiosulfate (STS) has recently been approved for systemic adminis...