A liposome-hydrogel composite ameliorates UVB-induced mouse skin photoaging through integrated antioxidant and extracellular matrix remodeling pathways [0.03%]
一种脂质体-水凝胶复合物通过抗氧化和细胞外基质重塑通路改善小鼠紫外线诱导的皮肤光老化
Yifan Liu,Kejia Chen,Jin Pei et al.
Yifan Liu et al.
Skin photoaging, predominantly caused by chronic ultraviolet B (UVB) exposure, is characterized by oxidative stress, collagen degradation, and disruption of the skin barrier. Deer placenta polypeptides (DPP) are rich in bioactive amino acid...
Ultrasound-triggered platelet vehicles loading fluorescein for targeted sonodynamic therapy of glioblastoma [0.03%]
一种用于胶质母细胞瘤靶向声动力治疗的载荧光素血小板载体超声触发释放装置
Yu-Xin Guo,Qing Deng,Ke Li et al.
Yu-Xin Guo et al.
Glioblastoma (GBM), the deadliest primary brain malignancy, resists treatment because of the blood‒brain barrier (BBB) and intrinsic resistance mechanisms. Fluorescein (FL), a clinically approved fluorophore, shows promise as a sonosensiti...
Development and in vivo pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol [0.03%]
一种磷脂复合自微乳化给药系统(PLC-SNEDDS)，用于增强大麻二酚口服生物利用度的开发及体内药动学评价研究
Thabata Muta,Songhita Mukhopadhyay,Benjamin Noll et al.
Thabata Muta et al.
Cannabidiol (CBD) exhibits poor oral bioavailability (approximately 6%) due to low solubility and excessive first-pass metabolism, limiting its therapeutic potential. This study introduces a novel phospholipid complex self-nanoemulsifying d...
Phytotherapeutics self-microemulsifying systems in pellet dosage form for enhanced intestinal drug delivery: formulation, stability, and in-vivo performance [0.03%]
用于增强肠道药物递送的植物疗法自微乳化系统颗粒制剂、稳定性和体内性能研究
Gabriela Koutná,Jan Kotouček,Jan Macků et al.
Gabriela Koutná et al.
Self-microemulsifying drug delivery systems (SMEDDS) containing volatile phytotherapeutics such as thymol (T), carvacrol (C), and eugenol (E) present significant formulation challenges, even when solidified. Their instability and interactio...
Wedelactone-loaded exosomes for sepsis-induced liver injury: a novel therapeutic strategy [0.03%]
载有楔藻烯的外泌体在败血症致肝损伤治疗中的应用
Yanping Yin,Lulu Zhang,Yanli Yin et al.
Yanping Yin et al.
Sepsis-induced liver injury (SILI) is an important cause of death in intensive care patients, which seriously affects clinical prognosis. Wedelolactone (WEL) exhibits hepatoprotective properties, however, its clinical application is constra...
Design and characterization of a resveratrol spray-dried inhalable formulation for pulmonary delivery with in vivo pharmacokinetic and toxicological evaluation [0.03%]
一种用于肺部递送的白藜芦醇喷雾干燥吸入配方的设计、表征及其体内药代动力学和毒性评价
Joanna Sobocińska,Chun Yuen Jerry Wong,Emre Gezer et al.
Joanna Sobocińska et al.
Resveratrol is a polyphenolic compound with therapeutic potential for pulmonary diseases, yet its use is limited mostly due to low oral bioavailability. Inhalable powder formulations are a promising strategy to help overcome those challenge...
Oral self-assembly nanoemulsion drives in vivo hepatic stellate cell-targeting drug delivery in liver fibrosis [0.03%]
一种口服药物递送系统用于治疗肝纤维化中的肝星状细胞病理功能
Xinjing Shen,Jie Deng,Aijiao Jiang et al.
Xinjing Shen et al.
Hepatic fibrosis is a chronic liver disease that requires long-term treatment and is characterized by the excessive accumulation of extracellular matrix (ECM), which is produced primarily by activated hepatic stellate cells (aHSCs). Oral me...
Dual-ligand-modified cantharidin nanoparticles for the treatment of hepatocellular carcinoma via the inhibition of Ephb4 [0.03%]
双配体修饰的斑蝥素纳米颗粒通过抑制Ephb4治疗肝细胞癌
Wanting Jiang,Hao Zheng,Shengmei Wang et al.
Wanting Jiang et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, yet conventional chemotherapy is limited by poor tumor specificity and severe toxicity. Cantharidin (CTD), a natural antitumor agent, is hindered by nephrotoxici...
Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood-brain barrier for improved therapy of cryptococcal meningitis [0.03%]
低强度脉冲超声结合微气泡增强两性霉素B穿过血脑屏障能力以改善隐球菌性脑膜炎治疗效果
Junyu Liu,Zhengtu Li,Dongcheng Li et al.
Junyu Liu et al.
Cryptococcal meningitis (CM), a life-threatening fungal infection of the central nervous system, faces therapeutic challenges due to poor blood‒brain barrier (BBB) penetration of amphotericin B. This study investigates the efficacy of low-...
Dual-mechanism vitamin C delivery by polyethylene glycol-23 glyceryl distearate-based niosomes via SVCT2 induction and enhanced transdermal penetration [0.03%]
基于聚乙二醇-23甘油二硬脂酸酯的nikosome通过SVCT2诱导和经皮渗透增强实现维生素C的双机制递送
Tatsuro Miyoshi,Brian C Keller,Sui Nakagawa et al.
Tatsuro Miyoshi et al.
Polyethylene glycol-23 glyceryl distearate (GDS-23)-a noisome-forming diacylglycerol-polyethylene glycol-based nonionic surfactant-functions as a nanocarrier for drug delivery systems (DDS) and an enhancer of endogenous antioxidant capacity...