Cerium oxide nanoparticles: antioxidant properties in silicosis treatment and biomedical application prospects-a dialectical consideration [0.03%]
二氧化铈纳米粒子在硅肺治疗中的抗氧化作用及其生物医学应用前景的辩证思考
Ge Ban,Yuanjie Chen,Ran Zhao et al.
Ge Ban et al.
Silicosis is a progressive fibrotic lung disease precipitated by chronic inhalation of crystalline silica. Uptake of silica particles by alveolar macrophages initiates a cascade of persistent inflammation and oxidative stress, in which reac...
Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells [0.03%]
基于适配体的脂质纳米颗粒实现mRNA向CD4+T细胞的靶向递送
Shrey Shah,Meenakshi Ranasinghe,John Decker et al.
Shrey Shah et al.
In vivo genetic engineering of T cells could overcome the logistical, biological, and safety challenges of ex vivo modification, but effective and safe delivery systems remain limited by a lack of cellular specificity. Here, we developed ap...
Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation [0.03%]
破解“不可成药”靶点：溶酶体受体介导的蛋白质降解领域的现状和新兴前沿
Yi-Meng Ma,Hou-Fu Xia,Yi-Lei Xiao et al.
Yi-Meng Ma et al.
Extracellular and membrane-associated proteins are essential in signal transmission, immunological control, and disease pathogenesis; nonetheless, their 'undruggable' characteristics have historically impeded drug discovery. The targeted pr...
ROS-triggerable dual nanocoated probiotics for inflammatory bowel disease treatment [0.03%]
用于治疗炎症性肠病的ROS触发型双重纳米涂层益生菌
Guangze Sang,Sizhen Wang,Qiwei Tai et al.
Guangze Sang et al.
Inflammatory bowel disease (IBD), an immune-mediated chronic gastrointestinal disease, is difficult to treat because its specific pathogenic mechanisms are currently unclear, and its recurrence rate is high. Probiotic therapies have been us...
Genetically engineered M13 phage-mediated H9N2 DNA vaccine with enhanced mucosal and systemic immune responses in mice [0.03%]
一种新型的由转基因M13噬菌体介导的禽流感(H9N2)DNA疫苗及其免疫效果研究
Xiaohua Wang,Zhi Zhao,Mingze Shi et al.
Xiaohua Wang et al.
Vaccine adjuvants and delivery systems have long been used in DNA vaccines to enhance immunogenicity. In this study, we developed a DNA vaccine delivery platform by combining N-2-hydroxypropyl trimethyl ammonium chloride chitosan/carboxymet...
Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis [0.03%]
线粒体功能障碍及靶向线粒体递送系统在动脉粥样硬化中应用的研究进展
Yanfang Liu,Nan Luo,Xin Xi et al.
Yanfang Liu et al.
Atherosclerosis, a chronic inflammatory disease, is pathologically associated with mitochondrial dysfunction. Mitochondria contribute to oxidative stress, vascular endothelial dysfunction, and chronic inflammatory cascades through pathways ...
A macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury [0.03%]
一种巨噬细胞模拟纳米载体联合载牻牛儿醇和FK13-a1治疗MRSA引起的急性肺损伤
Haonan Li,Binghong Xu,Junguang Liang et al.
Haonan Li et al.
Current clinical strategies for Methicillin-resistant Staphylococcus aureus (MRSA)-induced acute lung injury (ALI) predominantly focus on single-approach interventions such as anti-inflammatory therapy. However, due to the complex, multi-pa...
The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine [0.03%]
基于离子液体及羧基修饰聚乙烯亚胺的DNA递送系统研究与发展
Yaminn Thant,Parin Watcharavongtip,Patumporn Jermsutjarit et al.
Yaminn Thant et al.
Recombinant DNA vaccines offer significant potential for disease prevention and therapy, but their clinical success is often limited by poor immunogenicity, low cellular uptake, instability, and inefficient delivery without proper carriers....
Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions [0.03%]
口服胰岛素给药的再工程化：结构修饰、先进的配方策略和未来方向
Yilin Zheng,Xiaoyi Fang,Jiangtao Gao
Yilin Zheng
Oral insulin delivery represents a transformative approach to diabetes management, offering improved patient compliance and physiological insulin delivery patterns compared to subcutaneous injection. However, multiple gastrointestinal barri...
Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns [0.03%]
介孔硅纳米颗粒的潜力与生物医学应用及安全问题顾虑之间的平衡解锁
Yingze Hou,Can Zhu,Zhean Shen et al.
Yingze Hou et al.
Mesoporous silica nanoparticles (MSNs) have garnered significant attention across various disciplines, including chemistry, physics, and materials science, owing to their distinctive properties and functionalities. Numerous studies have dem...