Photosensitive composite nanoparticles adsorbing p-sh BLM for the synergistic therapy of neuroblastoma [0.03%]
用于神经母细胞瘤协同治疗的吸附p-sh bop的小胶质细胞照片敏复合纳米粒子
Xuelian Luo,Xiaohan Wu,Haifeng Ai et al.
Xuelian Luo et al.
Photodynamic therapy (PDT) represents a promising noninvasive modality for the selective targeting of tumors. However, its clinical utility is often constrained by the aggregation-induced quenching of photosensitizers and suboptimal reactiv...
Breakthroughs of ultrasound-targeted microbubble destruction in treating myocardial ischemia-reperfusion injury: from angiogenesis regulation to precise inflammation suppression [0.03%]
声动力聚焦治疗心肌缺血再灌注损伤的研究进展：从促血管生成到抗炎精准化治疗
Wei Feng,Pingping He,Zhimin Wang et al.
Wei Feng et al.
Myocardial ischemia-reperfusion injury (MIRI), a frequent complication in acute myocardial infarction (AMI) treatment, arises from complex mechanisms including oxidative stress, inflammation, and mitochondrial dysfunction, which impair myoc...
Multifunctional self-emulsifying drug delivery system: an efficient strategy for oral delivery of therapeutic peptides and proteins [0.03%]
多功能自我乳化的药物传输系统：口服给药输送治疗性肽和蛋白的有效策略
Guofei Li,Changyu Shao,Yuhao Zhang et al.
Guofei Li et al.
Oral delivery is the most preferred route for accessing bioactive peptides and proteins for disease treatment from the patient's viewpoint. However, this is a great challenge because orally administered peptides and proteins are susceptible...
Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation [0.03%]
声激励下微气泡增强药物渗透的协同效应及其建模研究
Yingjie Li,Jiwen Hu,Yunsu Wang et al.
Yingjie Li et al.
The high selectivity of the vascular endothelium, exemplified by the blood-brain barrier (BBB), provides critical protection to tissues against harmful substances; however, it also severely restricts the targeted delivery of therapeutic age...
Nanomaterial-mediated multidimensional regulation of the bone microenvironment: a precise therapeutic strategy for bone metabolic imbalance [0.03%]
纳米材料介导的骨微环境多维度调控：骨代谢紊乱精准治疗策略
Chengyan Guo,Chenyu Zhu,Wenjing Li et al.
Chengyan Guo et al.
With the advancement of global population aging, the incidence of skeletal diseases (e.g. osteoporosis, fractures, and osteoarthritis) in clinical diagnosis increases and poses a serious threat to human health. Skeletal diseases usually occ...
Utilization of DOX-Fe complex and RSL3 co-loaded liposomes in ferroptosis-enhanced treatment of triple-negative breast cancer [0.03%]
利用DOX-Fe复合物和RSL3共载脂质体增强铁死亡在三阴性乳腺癌治疗中的作用
Jinguo Li,Yuhao Zhang,Changyu Shao et al.
Jinguo Li et al.
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and is characterized by high invasiveness, rapid recurrence, and poor prognosis. To date, the ferroptosis-combined therapies have exerted their potential in t...
Blood‒brain barrier opening with Golay-coded ultrasound to improve therapeutic consistency in glioblastoma models [0.03%]
戈莱编码超声打开血脑屏障改善胶质母细胞瘤模型的治疗一致性
Seoyun Chang,Taekyu Jang,Hyochul Lee et al.
Seoyun Chang et al.
Transcranial-focused ultrasound has demonstrated potential for blood-brain barrier (BBB) opening and localized drug delivery to intracranial brain lesions, making it a promising therapeutic strategy for glioblastoma (GBM) treatment. However...
Comparative analysis of metabolome and transcriptomes to explore the inhibited influence of sonodynamic therapy combined with lonidamine on hepatocellular carcinoma [0.03%]
代谢组和转录组联合分析探索声动力学治疗联合洛莫司汀抑制肝癌的作用机制
Haoyan Tan,Huimin Tian,Yichi Chen et al.
Haoyan Tan et al.
Sonodynamic therapy (SDT) has emerged as a promising approach for treating hepatocellular carcinoma (HCC) by combining sonosensitizers with low-intensity ultrasound. However, SDT alone could not achieve satisfactory results. Here, we develo...
Comparative Study
Drug delivery. 2025 Dec 31;32(1):2593600. DOI:10.1080/10717544.2025.2593600 2025
Nanotechnology-based targeted regulation of NLRP3 Inflammasome: therapeutic strategies and clinical application prospects in inflammatory diseases [0.03%]
基于纳米技术的NLRP3炎性小体靶向调控在炎症性疾病治疗中的策略和临床应用前景研究
Xuan Zhao,Zhikai Xu,Dongfang Wang et al.
Xuan Zhao et al.
The NLRP3 inflammasome plays a critical role in the onset and progression of various inflammatory diseases, making targeting its activation an important research direction for treating these conditions. Nanotechnology can effectively inhibi...
Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport [0.03%]
一种新型的α7-乙酰胆碱受体选择性细胞穿透肽的开发，用于细胞内货物运输
Lahra Weber,Brittany C V O&#x;Brien,Maegan M Weltzin
Lahra Weber
Cell membranes present barriers to the intracellular delivery of therapeutic agents. This impediment is frequently exacerbated by the hydrophobic characteristics of many such molecules, ultimately reducing the efficiency of their cellular u...