De Novo Design of Protein Nanopores: From Minimal Peptides to AI-Driven Design [0.03%]
从最小肽段到人工智能驱动设计的蛋白质纳米孔从头设计
Anastassia A Vorobieva,Rituparna Samanta,Toon Van Thillo
Anastassia A Vorobieva
Protein nanopores offer a powerful platform for analytical applications by directly converting chemical properties into information-rich, single-molecule electrical readouts. However, engineering natural nanopores for sensing remains challe...
Sander Woutersen,Neil T Hunt
Sander Woutersen
Since its inception at the end of the last century, 2D-IR spectroscopy has undergone continuous development into an established method for studying the structure, dynamics and intermolecular interactions of biomolecules. Thanks to parallel ...
Earth-Abundant 3d Transition Metal-Catalyzed Enantioselective C-H Functionalization [0.03%]
基于地球丰富的第三过渡金属的催化C-H键手性官能团化的研究进展
Pu-Fan Qian,Jia-Heng Hu,Yan-Xuan Wu et al.
Pu-Fan Qian et al.
Transition metal-catalyzed enantioselective C-H functionalization has emerged as a next-generation synthetic paradigm, offering numerous opportunities for the de novo construction and late-stage modification of complex molecular architectur...
Conformational Switching on Lipid Interfaces: Lessons from Refolding and Membrane Insertion of Diphtheria Toxin, BCL-2 Apoptotic Regulators and pHLIP [0.03%]
基于脂质界面上白喉毒素、Bcl-2凋亡调节剂和pH诱导肽的重构及膜插入的构象转换研究
Alexey S Ladokhin
Alexey S Ladokhin
The conformational switching of a protein from its water-soluble conformation to its membrane-inserted conformation is critical for many cellular processes: cellular entry of bacterial toxins via escape from the endosome, apoptotic regulati...
Janice L Robertson
Janice L Robertson
Regarded as one of the most complex membrane protein folds, CLCs form a large family of membrane proteins that function as anion channels and secondary active anion/proton transporters. Despite low sequence similarity, available structures ...
Materials and Device Engineering for Efficient, Stable, and Scalable Monolithic Perovskite/Silicon Tandem Photovoltaics [0.03%]
高效稳定的钙钛矿/硅单片叠层太阳电池的材料与器件工程学研究
Lorenzo Mardegan,Ahmed Ali Said,Anil R Pininti et al.
Lorenzo Mardegan et al.
Rapid advances in photovoltaic technology have driven its exponential global deployment, establishing solar power as a central pillar of future electricity generation. Among next-generation photovoltaic concepts, perovskite/silicon tandem s...
Conditional Transmembrane Peptides as Allosteric Modulators: Thermodynamic and Functional Perspectives in Membrane Protein Regulation [0.03%]
条件性跨膜肽作为别构调节剂：膜蛋白调节的热力学及功能视角
Jennifer A Rybak,Francisco N Barrera
Jennifer A Rybak
Membrane proteins participate in most cellular processes from sensing the cellular environment to regulating gene expression. The fundamental unit in eukaryotic membrane proteins is the transmembrane (TM) helix, which in addition to anchori...
Erwin Reisner
Erwin Reisner
Fan Wang,Nikolaos Samartzis,Tao Wang et al.
Fan Wang et al.
Porous carbons are premier electrode materials for supercapacitors, yet overcoming the tradeoff between energy and power density remains a fundamental challenge. Guided by the overarching goal of achieving simultaneously high energy and hig...
Navigating Misfolded Terrain: ER-Associated Degradation of Membrane Proteins [0.03%]
膜蛋白的内质网相关降解：误折叠途中的导航
Devanshi Agarwal,Kristina Solorio-Kirpichyan,Eric M Jordahl et al.
Devanshi Agarwal et al.
Integral membrane proteins face unique folding challenges in the endoplasmic reticulum (ER) due to their hydrophobic transmembrane domains and complex topologies. Membrane protein misfolding disrupts ER homeostasis, contributing to diseases...