Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases [0.03%]
信号传导中配体偏向的作用机制及其表现形式：侧重受体酪氨酸激酶
Ryan J Schuck,Tanaya Roy,Ana-Nicoleta Bondar et al.
Ryan J Schuck et al.
The development of organisms and the maintenance of tissue homeostasis depend on complex intercellular signaling networks that govern basic cell functions. Because cells are typically exposed to many diverse ligands simultaneously, distinct...
Development and Prospects of Zirconia 3D Printing for Artificial Prosthesis Applications [0.03%]
用于人工假体应用的氧化锆3D打印的发展与前景
Hyein Lee,Dong-Hyun Lee,Jiyu Hyun et al.
Hyein Lee et al.
Artificial prosthetic manufacturing is moving toward patient-specific design and production, and zirconia-based three-dimensional printing is emerging as a promising approach because of its mechanical properties and biocompatibility. Yet th...
Function, Structure, and Regulation of Nitrogen Fixation-like Metalloproteins for Nitrogen, Energy, Carbon, and Sulfur Metabolism [0.03%]
氮固定类金属蛋白的功能、结构和调节——用于氮、能量、碳和硫代谢
Justin A North,Hannah S Shafaat
Justin A North
Nitrogenases (N2ases) and nitrogen fixation-like (NFL) systems play distinct roles in nitrogen, carbon, sulfur, and energy metabolism based on their fundamental differences in structure and metallocofactor identity. As new NFL systems have ...
Hierarchical Self-Assembly, Nanoarchitectonics, and Emerging Functionalities of Chiral π-Amphiphiles [0.03%]
手性π两亲分子的分层级自组装、纳米构筑及功能涌现现象
Guanghui Ouyang,Minghua Liu
Guanghui Ouyang
Rational design of functional building blocks and precise control over their hierarchical self-assembly form the cornerstones of supramolecular chemistry and materials science. Amphiphilic molecules, with their inherent hydrophilic-hydropho...
Huijie Zhang,Nicolas Plumeré
Huijie Zhang
Photosystem-modified electrodes have been developed as alternatives to classical semiconductor-based systems for solar energy conversion into chemicals or electricity. Photosystems, the photoactive proteins of natural photosynthesis, offer ...
Catalyst Design for Sustainable Reactions: A Primer toward Knowledge-Driven Innovation [0.03%]
可持续反应的催化剂设计：通向知识驱动创新之路
Pedro S F Mendes,Daniel P Costa,Jeroen Lauwaert et al.
Pedro S F Mendes et al.
When aiming at designing performant catalysts for existing or novel (sustainable) reactions, a wide variety of methodologies can be adopted, turning catalyst design into a science on its own. However, fundamental knowledge and clear guideli...
De Novo Design of Protein Nanopores: From Minimal Peptides to AI-Driven Design [0.03%]
从最小肽段到人工智能驱动设计的蛋白质纳米孔从头设计
Anastassia A Vorobieva,Rituparna Samanta,Toon Van Thillo
Anastassia A Vorobieva
Protein nanopores offer a powerful platform for analytical applications by directly converting chemical properties into information-rich, single-molecule electrical readouts. However, engineering natural nanopores for sensing remains challe...
Sander Woutersen,Neil T Hunt
Sander Woutersen
Since its inception at the end of the last century, 2D-IR spectroscopy has undergone continuous development into an established method for studying the structure, dynamics and intermolecular interactions of biomolecules. Thanks to parallel ...
Earth-Abundant 3d Transition Metal-Catalyzed Enantioselective C-H Functionalization [0.03%]
基于地球丰富的第三过渡金属的催化C-H键手性官能团化的研究进展
Pu-Fan Qian,Jia-Heng Hu,Yan-Xuan Wu et al.
Pu-Fan Qian et al.
Transition metal-catalyzed enantioselective C-H functionalization has emerged as a next-generation synthetic paradigm, offering numerous opportunities for the de novo construction and late-stage modification of complex molecular architectur...
Conformational Switching on Lipid Interfaces: Lessons from Refolding and Membrane Insertion of Diphtheria Toxin, BCL-2 Apoptotic Regulators and pHLIP [0.03%]
基于脂质界面上白喉毒素、Bcl-2凋亡调节剂和pH诱导肽的重构及膜插入的构象转换研究
Alexey S Ladokhin
Alexey S Ladokhin
The conformational switching of a protein from its water-soluble conformation to its membrane-inserted conformation is critical for many cellular processes: cellular entry of bacterial toxins via escape from the endosome, apoptotic regulati...