Rational Selection of Minimal Sensor Arrays for Analyte Fingerprinting [0.03%]
分析物指纹的最小传感器阵列的合理选择方法研究进展
Michael Faran,Gabriel Petresky,Minyeong Yoon et al.
Michael Faran et al.
High-dimensional, cross-reactive sensor arrays enable powerful chemical fingerprinting, but practical use is often limited by the difficulty of identifying a small, reliable subset of sensors from screening data that contain only a few repl...
Measuring Electron-Transfer Reaction Kinetics in Single Electrochemiluminescence Events at an Ultramicroelectrode for the Ru(bpy)32+/Tri- n- propylamine Coreactant System [0.03%]
Ru(bpy)32+/トリ-n-プロパノアミン共反应体系在超微电极上单次电致化学发光事件中的电子转移反应动力学研究
Zhenzhong Cai,Tianyu Wei,Zhifeng Ding
Zhenzhong Cai
Electrochemiluminescence (ECL) provides a unique analytical platform for probing electron-transfer kinetics via time-resolved photon detection. In coreactant ECL systems, however, quantitative determination of individual homogeneous rate co...
Five-in-One Neurodetoxification-Guardian-Type Near-Infrared Carbon Dots for Synergistic Blockade of Alzheimer's Disease Pathological Cascade [0.03%]
协同阻断阿尔茨海默病病理级联的五合一神经排毒守护型近红外碳点
Caiping Ding,Yuhan Zhang,Zikang Chen et al.
Caiping Ding et al.
Alzheimer's disease (AD) involves multiple interconnected pathologies, including amyloid-β (Aβ) aggregation, Cu2+ accumulation, oxidative stress, and mitochondrial dysfunction. Single-target therapies show limited efficacy, and most probe...
A SERS-Based Analytical Strategy for Real-Time Quantitative Kinetic Analysis and Inhibitor Screening for Cytochrome P450-Mediated PAH Metabolism [0.03%]
一种基于SERS的分析策略，用于定量动力学分析和CYTOCHROME P450介导的多环芳烃代谢抑制剂筛选
Yifan Li,Junbo Li,Yang Yang et al.
Yifan Li et al.
Exploring the metabolic kinetics mediated by cytochrome P450 (CYP) enzymes is essential for understanding pharmacokinetic and toxicological mechanisms. However, real-time monitoring of CYP-mediated enzymatic reactions remains challenging fo...
Development of a Midinfrared Cavity Ring-Down Spectrometer for High-Precision Analysis of Carbon Dioxide Clumped Isotopic Compositions [0.03%]
发展中红外腔衰荡光谱仪用于高精度分析二氧化碳氯化物同位素组成
Ningwu Liu,Kota Tsuge,Ryohei Terabayashi et al.
Ningwu Liu et al.
A midinfrared cavity ring-down (CRD) spectrometer was developed employing a 4.44 μm quantum cascade laser (QCL) for the sensitive detection of CO2 isotopologues, including 12C16O2 (44), 13C16O2 (45), 12C16O18O (46), and 13C16O18O (47). Ins...
In Situ NMR Tube Extraction Reveals Increased Fluorine Release with Polymer Swelling [0.03%]
原位NMR管提取揭示了随着聚合物溶胀氟释放的增加
Mitchell L Kim-Fu,Isabelle E Logan,Johanna Peeters Weem et al.
Mitchell L Kim-Fu et al.
An in situ nuclear magnetic resonance (NMR) tube extraction coupled with fluorine-19 (19F) NMR spectroscopy was developed to quantify extracted fluorine. A solid-liquid extraction of Viton A was performed in situ in an NMR tube whereby an o...
In Vivo Negligible Depletion SPME for the Determination of Free and Total Concentrations of Anandamide and 2-Arachidonoylglycerol in the Brain of a Parkinson's Disease Rat Model [0.03%]
体内几乎不消耗的SPME测定帕金森病大鼠模型脑中安那度胺和2-花生四烯酸甘油游离及总量的方法
Igor Gustavo Carvalho Oliveira,Glauce Crivelaro Nascimento,Elaine Del-Bel et al.
Igor Gustavo Carvalho Oliveira et al.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, and diagnosis typically occurs after substantial neuronal loss, underscoring the need for biomarkers capable of detecting early pathological changes. The endo...
Solid-Phase Fluorescence Filter Effect Based Test Kit for Field Testing of CODMn in Surface Water [0.03%]
基于固相荧光滤杯的现场快速测定地表水高锰酸盐指数试纸盒法检测方法标准
Yuanyuan Liu,Jinyi Zhang,Zhankuo Zhang et al.
Yuanyuan Liu et al.
On-site rapid monitoring of the permanganate index (CODMn) is critical for assessing the distribution and transformation of dissolved organic matter (DOM) in surface water. Herein, we proposed a portable field test kit for rapid, visual, an...
Precision Visualization of Tumor Microenvironment via a Lysosome-Anchored Molecular Rotor with Viscosity-Triggered Fluorescence Ignition [0.03%]
一种通过溶酶体固定分子马达实现粘度触发的肿瘤微环境精确诊断探针
Ning Ding,Bochao Chen,Feifei Jiang et al.
Ning Ding et al.
Intracellular viscosity is a key biomarker of the tumor microenvironment. However, most existing probes lacked tumor-targeting capabilities, limiting the accuracy of tumor detection and imaging analysis. Herein, we present a new fluorescent...
Enzyme-Activatable and Tumor-Targeted Nanosystem for Real-Time Imaging and Synergistic Zn2+-Interference Photothermal Therapy of Breast Cancer Bone Metastasis [0.03%]
用于实时监测和协同干扰乳腺癌骨转移的锌离子的肿瘤靶向型酶激活纳米系统
Yujia Zhang,Chen Zhao,Jukun Yang et al.
Yujia Zhang et al.
Bone metastasis is a frequent and debilitating complication in advanced breast cancer. Monitoring and treating bone metastasis remains challenging due to the inability of current imaging modalities to capture early molecular changes or prov...