Top-Down Characterization of Yeast tRNA by Gas-Phase Fractionation and Collisionally Activated Dissociation Informed by Electron Photodetachment Charge Reduction Mass Spectrometry
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Many transfer RNAs (tRNAs) are heavily modified and exhibit high sequence heterogeneity, making them challenging targets for characterization. Tandem mass spectrometry can interrogate multiple covalent modifications present on a single type of tRNA at the nucl... ...
