Overcoming the Thermodynamic Diffusion Barrier in DNA Cascade Amplifiers via Spatially Confined Entropy Reduction: A Versatile Kinetic Engineering Framework [0.03%]
通过空间限制熵减克服DNA级联放大器中的热力学扩散障碍：一种通用的动力学工程框架
Zhenyu Wang,Youwei Chen,Zhiyi Wu et al.
Zhenyu Wang et al.
The reaction efficiency of solution-phase DNA cascade amplifiers is fundamentally constrained by stochastic Brownian motion, creating a thermodynamic diffusion bottleneck that limits sensitivity and speed. To overcome this, we present a gen...
A Host-Guest-Regulated Photocurrent Polarity Switching with a "Binary" Strategy for False-Positive-Free Microbial Detection of Staphylococcus aureus [0.03%]
一种用于无假阳性的金黄色葡萄球菌检测的“二进制”策略 host-guest 调控光电流切换方法
Wenjie Zhang,Fei Tan,Wenxuan Guo et al.
Wenjie Zhang et al.
Herein, we report a supramolecular photoelectrochemical (PEC) biosensor based on a signal-polarity-inversion strategy, integrated with bacterial imprinting technology, for the ultrasensitive and selective detection of Staphylococcus aureus ...
High Accurate Micro-Orifice Resistance Assay with Programmable Aggregation-Dispersion Switching Enabled by an Entropy-Driven Circuit [0.03%]
基于熵驱动电路的可编程聚集解离切换高精度微孔电阻检测法
Feng Hong,Liangqiong Ren,Wenshu Zheng et al.
Feng Hong et al.
Rapid and sensitive detection of pathogenic bacteria remains challenging due to insufficient signal gain and uncontrollable signal transduction strategies that are easily perturbed by environmental fluctuations. Here, we present a micro-ori...
A Live-Cell Analytical Platform by Using Strigolactones-Induced Dimerization System [0.03%]
异丝因子诱导二聚化系统活细胞分析平台
Kun Zang,Xinwei Lu,Chaoliang Diao et al.
Kun Zang et al.
Chemical-induced dimerization (CID) offers a strategy for constructing live-cell analytical platforms by enabling chemically programmable perturbations. However, widely used CID systems often lack orthogonality, exhibit complex concentratio...
Rational Design of an Isoform-Specific Fluorogenic Probe for Human UGT2B7: Enabling Functional Analysis and Inhibitor Screening [0.03%]
人类UGT2B7等位基因特异性荧光探针的理性设计：用于功能分析和抑制剂筛选
Xin-Fang Zhai,Zhe Wang,Xiang-Jing Fu et al.
Xin-Fang Zhai et al.
UDP-glucuronosyltransferase 2B7 (UGT2B7), a pivotal drug-metabolizing enzyme, plays a critical role in conjugating and detoxifying diverse nonpolar xenobiotics. However, few methods exist for conveniently monitoring UGT2B7 function in biolo...
Interpretable Wavelet-CNN for Accurate Serum Raman Lung Cancer Diagnosis under Leakage-Safe, Patient-Level Splits [0.03%]
基于Wavelet-CNN的解释性拉曼光谱肺癌诊断方法及患者级数据集划分策略
Jinglei Zhang,Bo Dai,Hong Wang et al.
Jinglei Zhang et al.
Clinical cancer diagnostics require ML that maintains accuracy under biological variability with interpretable feature attribution─a particular challenge for serum-based approaches where healthy and diseased samples share >95% chemical com...
In Situ Raman Spectral Visualization of Interfacial pH Disparities Governed by the Surface Structure of Nanoscale Oxides in Water [0.03%]
纳米氧化物在水中的界面pH差异的原位拉曼光谱可视化及其由表面结构决定的性质研究
Weiwei Ma,Yuchen Tang,Tingjuan Gao
Weiwei Ma
Proton transfer at solid-liquid interfaces governs catalysis, energy storage, and environmental processes but remains poorly understood due to the critical yet elusive disparity between interfacial and bulk pH. Here, we report a versatile a...
Probing the Accelerated Electron Transfer from Co to Fe within a Cyanide Framework Using Electrochemiluminescence Microscopy [0.03%]
利用电致化学发光显微镜研究氰化物框架中Co向Fe的加速电子转移现象
Jiaqi Gao,Mingtong Cai,Jian-Bin Pan et al.
Jiaqi Gao et al.
The coordination environment of metal centers is pivotal to the catalytic performance of heterogeneous catalysts, including Prussian blue analogues. However, elucidating the structure-activity relationship at the single-particle level under...
An Integrated Wasserstein GAN-Transformer Deep Learning Framework for Accurate Raman Spectral Identification of Escherichia coli Strains [0.03%]
一种集成的Wasserstein GAN-Transformer深度学习框架，用于准确识别埃希氏大肠杆菌谱系的拉曼光谱
Ying Xue,Bokang Sun,Ying Zhang et al.
Ying Xue et al.
Rapid and precise discrimination of Escherichia coli strains─including both pathogenic and nonpathogenic variants─is essential for clinical diagnosis and food safety monitoring. Raman spectroscopy provides nondestructive molecular fingerp...
Direct Identification of Microplastics by Ambient Pyrolysis Electrospray Ionization Mass Spectrometry [0.03%]
基于大气压裂解电喷雾离子化质谱直接鉴别微塑料
Zhiru He,Qingfu Zhang,Xi Xu et al.
Zhiru He et al.
Electrospray ionization (ESI) is one of the most widely used ionization methods in commercial mass spectrometry. However, it is challenging to effectively ionize most nonpolar plastics. In this study, a low-cost, rapid, free of complex samp...