Atomic Ga Site Enables Photonanozymes with Specific Inhibition Modes for Primary Drug Screening [0.03%]
原子镓位点使光纳米酶具有特定抑制模式以用于药物初筛
Jian Li,Yu Wu,Wenxuan Jiang et al.
Jian Li et al.
Enzyme inhibition plays a crucial role in drug discovery by governing interactions between molecules and distinct enzymatic sites, facilitating the identification of early drug candidates. However, most nanozymes have been limited to single...
Challenges and Advances of Interstitial Skin Fluid Wearable Smart Sensors on Emerging Microneedle Platforms [0.03%]
新兴微针平台下皮肤间质液可穿戴智能传感器的挑战与进展
Shuoshuo Wan,Ying Wang,Xin Li et al.
Shuoshuo Wan et al.
Interstitial skin fluid (ISF) holds great potential in bioassays as its components are similar to blood, offering a noninvasive alternative for disease diagnosis, prevention, and treatment. Microneedles (MNs), a novel biomedical tool, enabl...
Understanding Fast and Slow Signal Changes in a Competitive Particle-Based Continuous Biosensor [0.03%]
基于粒子的竞争性连续生物传感器中快慢信号变化的理解
Sebastian Cajigas,Arthur M de Jong,Junhong Yan et al.
Sebastian Cajigas et al.
The development of continuous biosensing technologies requires studies on time-dependent changes in sensor properties because such changes can impact the analytical performance of the sensor. In previous work, we studied long-term changes o...
CdS Quantum Dots-Regulated g-C3N4 Electrochemiluminescence and Photoelectrochemical Performance for Multimodal Sensing and Imaging Assay of Vibrio parahaemolyticus [0.03%]
用于多重检测和成像的CdS量子点调节g-C3N4电化学发光和光电化学性能以检测副溶血性弧菌
Yuting Du,Xiaojie Li,Jiajie Zhang et al.
Yuting Du et al.
In order to solve the problem of low electrochemiluminescence (ECL) intensity and resolution for imaging detection, we innovatively discovered for the first time that the ECL quantum efficiency of the CdS quantum dots (QDs)/g-C3N4/K2S2O8 sy...
Marshall J Smith,Guilherme Dal Poggetto,Cláudio F Tormena et al.
Marshall J Smith et al.
Incorporating fluorine into pharmaceutical candidates has typically led to improved medicinal properties, increasing the number of fluorinated active ingredients on the market. This increase requires that robust analytical tools be develope...
Dual-Drive Platform Combining Biotransformation Prediction and Diagnostic Ion Cluster Reveals Novel Type B Trichothecenes in Wheat [0.03%]
结合生物转化预测和诊断离子群的双驱动平台揭示了小麦中的新型B型三氧杂环乙烷类污染物
Jin Ye,Yu Wu,Sisi Liu et al.
Jin Ye et al.
Type B trichothecenes (B-TCTs) and their metabolites pose significant risks to both human and animal health and are the most common mycotoxin found in wheat. However, the identification of unknown B-TCT metabolites remains a considerable ch...
High-Throughput Analysis of Protein Adsorption to a Large Library of Polymers Using Liquid Extraction Surface Analysis-Tandem Mass Spectrometry (LESA-MS/MS) [0.03%]
基于液相抽提表面分析-串联质谱技术的高通量多聚体蛋白质吸附研究
Joris Meurs,Aishah Nasir,Grazziela P Figueredo et al.
Joris Meurs et al.
Biomaterials play an important role in medicine from contact lenses to joint replacements. High-throughput screening coupled with machine learning has identified synthetic polymers that prevent bacterial biofilm formation, prevent fungal ce...
High-Output Droplet Electricity Generator for Intelligent Self-Powered Biochemical Analysis [0.03%]
一种高通量液滴生化智能自驱动检测系统
Zihan Jin,Yuhang Xue,Lunyi Yuan et al.
Zihan Jin et al.
The detection and analysis of chemical and biological substances are crucial in fields such as pharmaceuticals, disease diagnosis food safety and environmental monitoring. However, traditional analytical methods often involve complex proced...
Spatially Resolved Multibait Mapping of Stress Granule and Processing Body Transcriptome [0.03%]
基于多诱饵的空间解析的应激颗粒和处理体转录组映射
Ziqi Ren,Songrui Zhao,Wei Tang et al.
Ziqi Ren et al.
Stress granules (SGs) are dynamic, membrane-less organelles that house complex RNA-protein networks. Although previous profiling methods have characterized SG RNAs as long, translation-repressed, and extensively epigenetically modified, it ...
Shape-Selective Separation of Model Analytes in Normal-Phase Liquid Chromatography: A Combined Simulation-Experimental Study [0.03%]
正常相液相色谱模型分析物形状选择性分离：结合模拟和实验的研究
Rustam Durdyyev,Malvina Supper,Jan-Christoph Domagala et al.
Rustam Durdyyev et al.
In this study, we demonstrate that liquid chromatographic separation can be effectively achieved based on shape differences, even for analytes of very similar chemical characters. Using a combined experimental-theoretical approach, we inves...