Rational Design of an Isoform-Specific Fluorogenic Probe for Human UGT2B7: Enabling Functional Analysis and Inhibitor Screening
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UDP-glucuronosyltransferase 2B7 (UGT2B7), a pivotal drug-metabolizing enzyme, plays a critical role in conjugating and detoxifying diverse nonpolar xenobiotics. However, few methods exist for conveniently monitoring UGT2B7 function in biological systems. Herei... ...
