Boron-Nitrogen Co-Doped Polymer Dots as a Metal-Free and Substrate-Free Fluorescent Nanozyme for Dual-Modal Monitoring of Catechol [0.03%]
用于多模态监测邻苯二酚的无金属和基底的硼氮共掺杂聚合物点纳米酶
Jiexi Liang,Zhimin Mo,Li Zhou
Jiexi Liang
The environmental persistence and carcinogenicity of catechol (CC) necessitate sensitive, portable detection methods beyond complex instrumentation. This work addresses this challenge by developing a novel metal-free fluorescent nanozyme, b...
Development of a Self-Activating Dandelion-Shaped DNA Nanodevice for Amplified Imaging of mRNA and Precise Gene Silencing [0.03%]
一种自我激活的蒲公英状DNA纳米装置用于mRNA放大成像和精确基因沉默的发展
Yun Han,Weijie Tong,Fei Ma et al.
Yun Han et al.
Messenger RNAs (mRNAs) are a key regulatory factor of gene expression, and their dysregulated expression is closely associated with the occurrence and prognosis of various diseases. The sensitive monitoring of mRNAs in living cells is vital...
Iulia Sidorov,Nina Ogrinc,Lena Spieth et al.
Iulia Sidorov et al.
Spatial biology has emerged as a pivotal area in many life science fields, with mass spectrometry imaging (MSI) becoming a cornerstone for molecular imaging. Among recent advancements to increase sensitivity, MALDI-2 technology has signific...
Deep Learning-Assisted G4 Nanowire-Enhanced Carbon Dot Biosensor for Exosomal LncRNA Artificial Intelligence Diagnosis [0.03%]
深度学习辅助G4纳米线增强型碳点生物传感器用于外泌体LncRNA人工智能诊断
Ruiying Yang,Zhiyi Yan,Jiangying Ji et al.
Ruiying Yang et al.
Exosomal long noncoding RNAs (lncRNA) have significant potential as a biomarker for early cancer diagnosis. Accurate and sensitive detection of this abnormal expression remains challenging. Herein, we develop an innovative dual-mode photoel...
Rapid and Sensitive Quantification of Nano- and Microplastics in Water, Sediment, and Biological Tissue by Pyrolysis-Gas Chromatography Tandem Mass Spectrometry with Dynamic Reaction Monitoring [0.03%]
基于动态反应监测的热裂解-气相色谱-串联质谱法在水、沉积物和生物组织中快速灵敏地定量纳米级及微塑料
M Bryan Gahn,Marcus Wharton,Asif Mortuza et al.
M Bryan Gahn et al.
A highly sensitive and selective method was developed for the quantification of nano- and microplastics (NMPs) in water, sediments, and biological tissues using pyrolysis gas chromatography coupled with triple quadrupole mass spectrometry (...
Establishing 19F NMR for Understanding Sorbent Interactions with Per- and Polyfluoroalkyl Substances (PFAS): Ranking Affinity and Dissecting Interactions of Nanoscale Carbon Dots and β-Cyclodextrin with PFAS [0.03%]
建立19F NMR技术以了解吸附剂与全氟和多氟烷基物质(PFAS)相互作用：纳米碳点和β-环糊精与PFAS亲和力分级及相互作用机理分析
Riley E Lewis,Cheng-Hsin Huang,Ana Katrina Tiu et al.
Riley E Lewis et al.
Developing new technologies for removal of per- and polyfluoroalkyl substances (PFAS) from water is critical for public and environmental safety. In conjunction, suitable analytical techniques are required for understanding interactions bet...
Epoxidation-Enhanced Charge-Switch Derivatization for Rapid Profiling of Monounsaturated Fatty Acid Isomers [0.03%]
环氧增强的电荷切换衍生化快速剖析单不饱和脂肪酸异构体的方法
Sarah E Hancock,Linda Garthwaite,Laura L Y Choong et al.
Sarah E Hancock et al.
Structural isomerism in monounsaturated fatty acids (MUFAs) presents a persistent challenge in lipidomics due to limited chromatographic resolution and indistinguishable mass spectral profiles. Moreover, many methods that overcome these lim...
Deep Learning Algorithms Enabled Visual Detection of Anthrax Biomarkers by Mn3O4 Nanozyme-Based Colorimetric Sensor Array [0.03%]
基于Mn3O4纳米酶的比色传感器阵列利用深度学习算法进行视觉检测炭疽生物标志物
Ziqian Gao,Mengxuan Liu,Lei Meng et al.
Ziqian Gao et al.
This study develops an innovative approach that integrates a colorimetric sensor array (CSA) composed of phenylalanine-modified Mn3O4 nanozymes with advanced algorithms, aiming to detect the anthrax biomarker 2,6-pyridine dicarboxylic acid ...
Scaling Peptide-Barcode Approach for Parallel Evaluation of Protein Expression from Multiple mRNA Variants [0.03%]
用于平行评估来自多种mRNA变体的蛋白质表达的肽编码条形码方法的扩展性研究
Shun Kumano,Kazuki Tanaka,Shoko Kawakami et al.
Shun Kumano et al.
Messenger RNA (mRNA) technology has revolutionized therapeutic design, yet optimizing untranslated regions (UTRs) and synonymous codons still depends on low-throughput, trial-and-error workflows. We previously reported a peptide-barcode met...
Barbara Umfahrer,Jakub Buday,Pavel Pořízka et al.
Barbara Umfahrer et al.
Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS), particularly in its time-of-flight (TOF) configuration, enables rapid, high-resolution elemental imaging across complex geological materials, offering spatial and chem...