Novel XAD-LC/MS-FBMN-IMS Strategy for Screening Holo- Hydroxamate Siderophores: Siderome Analysis of the Pathogenic Bacterium Tenacibaculum maritimum [0.03%]
一种新型XAD-LC/MS-FBMN-IMS策略用于筛选完整的羟胺细菌铁载体：海洋致病菌Tenacibaculum maritimum的细菌素分析
Lucía Ageitos,Larissa Buedenbender,M Pilar Escribano et al.
Lucía Ageitos et al.
Hydroxamate siderophores are key virulence factors in multiple pathogens, and their structures present interesting scaffolds for potential biotechnological applications such as the design of novel antimicrobials. However, their variable and...
First Fluorescent Probe for TREX1 Enables Real-Time Tracking of DNA Repair and Immune Regulation in Cancer Cells [0.03%]
首个TREX1荧光探针实现在癌细胞中对DNA修复和免疫调控的实时追踪
Ying Sun,Jinghui Zheng,Yupei Zhang et al.
Ying Sun et al.
Three Prime Repair Exonuclease 1 (TREX1) is the most abundant 3' exonuclease in human cells, playing a pivotal and complex role in both autoimmune regulation and cancer immunity. Despite its importance, existing methods have been insufficie...
Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics [0.03%]
采用直接质谱技术、电子捕获解离和分子动力学解析利拉鲁肽隐秘寡聚化途径
Syuan-Ting Kuo,Zhenyu Xi,Xiao Cong et al.
Syuan-Ting Kuo et al.
Peptide therapeutics have revolutionized drug design strategies, yet the inherent structural flexibility and conjugated moieties of drug molecules present challenges in discovery, rational design, and manufacturing. Liraglutide, a GLP-1 rec...
Structure Elucidation for MALDI Mass Spectrometry Imaging Using Infrared Ion Spectroscopy [0.03%]
基于红外离子谱学的基质辅助激光解析电离质谱成像结构阐明研究
Jelle L Schuurman,Lara van Tetering,Kas J Houthuijs et al.
Jelle L Schuurman et al.
Infrared ion spectroscopy (IRIS) is a tandem mass spectrometry (MS) technique that generates structurally diagnostic vibrational spectra for mass-selected ions trapped in a mass spectrometer. Until now, IRIS applications for biological samp...
Studying the Effect of Receptors Clustering on Hyaluronic Acid Binding with CD44 and the Cell Entry of Hyaluronic Acid Targeting Nanodrugs at Single Molecule/Particle Level [0.03%]
单分子/颗粒水平研究透明质酸受体聚集对细胞外基质糖胺聚糖透明质酸与受体CD44结合及透明质酸靶向纳米药物细胞摄取的影响
Xuening Li,Zhuang Zhang,Siying Li et al.
Xuening Li et al.
Receptor-ligand interactions on cell membrane play key roles in many physiological and pathological processes, especially in the nanodrug targeted delivery system. Hyaluronic acid (HA) is the main ligand for binding CD44 to modulate the tar...
Chemoproteomic Profiling of Isoprenoid Pyrophosphate Interacting Proteins with Photoaffinity Probes [0.03%]
用于异戊二磷酸相互作用蛋白质的光亲和探针化学蛋白质组学谱分析
Jing Tan,Can Gao,Liangyuan Ni et al.
Jing Tan et al.
Isoprenoid pyrophosphates are key intermediates in the biosynthesis of many biologically important molecules and in the prenylation of proteins involved in various biological processes. Except for these well-studied functions, new roles of ...
Hydrophilic Interaction Chromatography HRMS with Acrylamide Monolithic Columns: A Novel Approach for Intact Antibody Glycoform Characterization [0.03%]
亲水作用高分辨率质谱结合丙烯酰胺整体柱：一种完 整抗体糖型表征的新方法
Annika A M van der Zon,LoÏs N Hana,Huda Husein et al.
Annika A M van der Zon et al.
Glycosylation significantly impacts the pharmacokinetics and efficacy of monoclonal antibody (mAb) biotherapeutics. Characterizing mAbs' glycoform profiles is crucial for optimizing therapeutic outcomes, and intact antibody analysis provide...
A Closed-Loop Environmental Health Management Platform: A Multifunctional MgFe2O4 Nanoparticle Enabling AI-Enhanced Detection, Bioimaging, and Degradation of Tetracycline Antibiotics [0.03%]
一种闭环环境健康管理系统平台：一种多功能的镁铁氧体纳米粒子，可增强AI检测、生物成像和四环素抗生素降解能力
Youbin Zhuo,Xiuzhi Chen,Jiayi Luo et al.
Youbin Zhuo et al.
Emerging pollutants such as tetracycline antibiotics (TCs) have garnered attention due to their ecological impacts and the evolution of drug resistance. However, the comprehensive monitoring of TCs remains inadequate. This study presents a ...
A Single Carbon Microyarn-Based Integrated Wearable Textile Sweat Sensor Built into a Hook-and-Loop Fastener [0.03%]
一种基于碳微纱的一体化可穿戴纺织品汗液传感器，内置魔术贴中
Jian Cai,Wei Deng,Ziyu Zhu et al.
Jian Cai et al.
By fusing wearable sweat sensors for on-body sweat monitoring with textiles for daily wear, wearable textile sweat sensors (WTSSs) demonstrate the distinctive capability to monitor perspiration in real time while engaging in daily activitie...
Hypersensitive Multiparametric MRA for Mild Traumatic Brain Injury: Simultaneous Imaging of Hemorrhagic Foci, Vascular Integrity, and Collaterals [0.03%]
针对轻度脑外伤的高敏感性多参数MRA：出血病灶、血管完整性和侧支的同时成像
Wenyue Li,Mingxia Jiao,Yao Li et al.
Wenyue Li et al.
Diagnosing mild traumatic brain injury (mTBI) remains a significant clinical challenge as many injuries are either invisible or difficult to detect with conventional medical imaging techniques. Here, an advanced multiparametric magnetic res...