Self-Assembled DNA Nanoladder-Based Electrochemical Biosensor for Rapid and Sensitive Detection of Bladder Tumor-Related miRNA in Urine [0.03%]
基于尿液中自组装的DNA纳米梯级的电化学生物传感器快速灵敏检测膀胱肿瘤相关miRNA
Jiaoli Wang,Jingping Liu,Yajun Wang et al.
Jiaoli Wang et al.
Early diagnosis is critical for improving the survival rate of patients with bladder cancer (BCa), and urinary biomarker detection offers a promising noninvasive approach for early BCa screening. However, the typically low abundance of thes...
The Specific Low-Interference dsDNA Copper Nanoclusters for Visual Fluorescent Detection and Quantification of the EGFR L858R Point Mutation in Whole Single-Tube Magnetic Purification System [0.03%]
一种用于可视化检测和定量肺癌病人血液中EGFR基因L858R点突变的铜纳米团簇及其全血单管净化系统
Ke-Peng Lai,Ravery Sebuyoya,Kung-Hung Lin et al.
Ke-Peng Lai et al.
Existing fluorescence-based techniques for single-nucleotide variation detection are limited by nonspecific fluorescence interference and complex analytical workflows. To address these challenges, we developed a single-tube fluorescence det...
Toward High Performance Liquid Chromatography with Hierarchically Porous Metal Organic Framework Spheres (HP-MOFS) [0.03%]
具有分层孔金属有机框架球体的高效液相色谱研究(HP-MOFs)
Qiang Li,Hanchen Cao,Jikai Chen et al.
Qiang Li et al.
Metal-organic frameworks (MOFs) have emerged as a promising type of chromatographic stationary phase, owing to their unique size- and shape-selectivity conferred by the material's ordered microporous structure. Currently, the applicability ...
Quantitative Electroanalysis in Ionic Liquids Using Scanning Electrochemical Cell Microscopy [0.03%]
利用扫描电化学电池显微镜在离子液体中进行定量电分析研究
Samaneh Salek,Joshua C Byers
Samaneh Salek
Steady-state voltammetry of the redox mediator ferrocene in the room temperature ionic liquid, 1-ethyl-3-methylimidazolium tetrafluoroborate was carried out using scanning electrochemical cell microscopy (SECCM) on a glassy carbon substrate...
Spatially Resolved Laser Tweezers Raman Spectral Snapshots Reveal Single-Cell Molecular Heterogeneity [0.03%]
空间分辨的激光镊子拉曼光谱揭示单细胞分子异质性
Jiuyi Sun,Yiwei Tou,Pai Liu et al.
Jiuyi Sun et al.
Tumor heterogeneity is the major driver of cancer drug resistance, but its quantitative in situ characterization remains difficult to probe at the single-cell level. Here, laser tweezers Raman spectroscopy (LTRS) is employed to achieve micr...
Organic Macrocycle as Highly Selective Adaptor for Nanopore Sensing of Aromatic Carboxylic Acids in Oilfield Produced Water [0.03%]
用于油藏采出水中芳香族羧酸纳米孔传感的高选择性有机大环适配体
Rui Shi,Yun-Dong Yin,Lei Yang et al.
Rui Shi et al.
Aromatic carboxylic acids (ACAs) play a critical role in determining the disposal strategy of oilfield produced water (PW). In this work, we report a single-molecule nanopore sensor for the discrimination of six distinct ACAs. By employing ...
Jennifer L Janovick,Peter F Scholl,Katherine S Carlos et al.
Jennifer L Janovick et al.
Food contact paper (FCP) often has polymer treatments applied for grease- and water-resistance. These polymer food contact substances (FCS) are a potential source of dietary exposures to per- and polyfluoroalkyl substances (PFAS). Due to po...
Zhaoxi Zheng,Pyae Phyo,Yang Liu et al.
Zhaoxi Zheng et al.
Jie Wu,Fang-Hua Lu,Li-Ye Tao et al.
Jie Wu et al.
Simultaneous characterization of proteomic and metabolomic profiles at the single-cell level is crucial for deciphering cellular heterogeneity and elucidating disease mechanisms. However, it is still a great challenge to achieve high-depth ...
Development of a Highly Sensitive 31P{1H} NMR-Based Method for Trace-Level Detection of Alkylphosphonic Acids as Environmental Markers of Deadly Nerve Agents [0.03%]
开发一种高灵敏度的31P{1H}NMR法检测烷基膦酸类 nerve agents环境标记物的方法
Sweeti,Ajeet Kumar,Mohammed Mohsin et al.
Sweeti et al.
Nerve agents with P-C linkage, viz. sarin, soman, cyclosarin, VX, Novichok A-230, and their analogues are highly toxic in nature and produce alkylphosphonic acids (APAs) upon environmental degradation. The Organization for the Prohibition o...