Deep Learning-Assisted Nanocavity Sensor for Amphiphilic Biomarker Analysis [0.03%]
深度学习辅助纳腔传感器用于两亲性生物标志物分析
Bowen Fu,Zhiyi Yuan,Dong Yang et al.
Bowen Fu et al.
Fluorescence enhancement using nanocavity structures is a promising approach for rapid detection of amphiphilic biomarkers, which are essential for diagnosing diseases such as cancer and infections. This paper presents the use of a silver n...
Microarray-Based Nanoextraction Combined with Ambient Ionization Mass Spectrometry for Analysis of Drugs of Abuse in Wastewater [0.03%]
基于微阵列的纳米萃取结合电喷雾解吸电离质谱测定污水中的毒品分子
Malek Hassan,Daniel O Reddy,Abdul Rahman Alashraf et al.
Malek Hassan et al.
There is a significant need to simplify the analytical workflow for complex sample analysis. In particular, those innovations that are high-throughput, miniaturized, reliable, and more-resource conscientious are especially important. Given ...
Developing a Two-Dimensional Size-Exclusion Liquid Chromatography Platform for Isolating the High-Quality Extracellular Vesicles to Predict and Evaluate Metabolic Improvement Outcomes of Sleeve Gastrectomy [0.03%]
开发二维尺寸排除液相色谱平台以分离高质量的细胞外囊泡以预测和评估袖状胃切除术代谢改善效果
Weiwei Chen,Jindian Xu,Huanya Yang et al.
Weiwei Chen et al.
The direct analysis of plasma exosomal components still presents significant challenges due to the interference of high concentrations of albumin, immunoglobulins, and other abundant proteins. Herein, we developed a two-dimensional size-exc...
Quantitative Assessment of a Novel Device Designed for Patient-centric Sampling of Dried Plasma Using Targeted Proteomics [0.03%]
基于靶向蛋白组学的新型干燥血浆患者中心采样装置的定量评估研究
Andreas Hober,Marcus Henricsson,Tim Ruckh et al.
Andreas Hober et al.
Technological advancements have significantly enhanced proteomics by improving the quality, depth, and timeliness of proteomic data, making mass spectrometry a promising tool for personalized medicine. To enable successful longitudinal popu...
Water-Induced Structural Instability in Zinc Coordination Polymers for Dual-Channel Fluorescent Sensing of Cu2+ and Cysteine [0.03%]
用水致变色的锌配位聚合物用于铜离子和半胱氨酸的双通道荧光传感
Huang-Jie Li,Shunxing Li,Ya-Lin Zhang et al.
Huang-Jie Li et al.
Coordination polymers (CPs) have gained significant attention due to their unique structural tunability and broad application prospects. However, their instability in water remains a key challenge for practical applications. This study pres...
Bipolar Electrochemiluminescence Detection of Ampicillin Resistance Genes via HRCA-Mediated Precipitation-Induced Conductivity Modulation [0.03%]
基于导电性调制的席夫碱沉淀法定量扩增子及青霉素抗性基因的 bipolar 电解发光检测法
Bifang Yang,Weiqiang Yang,Fan Chen et al.
Bifang Yang et al.
Antibiotic resistance genes pose a significant threat to public health, highlighting the urgent need for rapid and sensitive detection methods. In this study, a bipolar electrochemiluminescence (BPE-ECL) sensing strategy was developed for d...
Sensitive Chemiluminescent Immunoassay Based on Synergistic Antioxidative Behavior Between Atomically Dispersed Mn Active Centers and Defect-Rich CuFe-Layered Double Hydroxide [0.03%]
基于原子分散的Mn活性中心与缺陷丰富的CuFe-层状双氢氧化物协同抗氧化行为的化学发光免疫分析法
Yehan Fan,Yuchan Ma,Jin Yang et al.
Yehan Fan et al.
Single atom nanozymes (SAEs), featuring atomically dispersed metallic active centers and maximum atomic utilization efficiency, have demonstrated outstanding catalytic activity compared with conventional nanozymes. The interaction between m...
Efficient Denoising of Shot-Noise in Mass Spectrometry Images by PCA-Assisted Self-Supervised Deep Learning [0.03%]
基于PCA的自监督深度学习在质谱成像中的高效降噪方法
Claire Seydoux,Matthew Bryan,Jean-Paul Barnes et al.
Claire Seydoux et al.
Mass spectrometry imaging (MSI) often suffers from inherent noise due to signal distribution across numerous pixels and low ion counts, leading to shot noise. This can compromise the accurate interpretation, especially for trace molecules. ...
Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders [0.03%]
基于LC-MS的单细胞脂质组学室间研究揭示了X射线辐射对胰腺癌细胞系及其旁观者细胞的影响
Kyle D G Saunders,Johanna von Gerichten,Rahul Deshpande et al.
Kyle D G Saunders et al.
Live single-cell lipidomics by liquid chromatography mass spectrometry (LC-MS) is a nascent and rapidly growing field which can shed new light on infectious diseases, cancer, immunology, and drug delivery. There are now a growing number of ...
Energetic Materials as Matrices for MALDI-TOFMS Analysis of High-Molecular-Weight Polyvinylidene Fluoride- co-chlorotrifluoroethylene [0.03%]
用作高分子量聚偏二氟乙烯-四氟乙烯的能量材料基质矩阵的研究MALDI-TOFMS分析
Colleen L Ray,Chris E Freye
Colleen L Ray
Since the invention of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS), this method has lent itself well to the analysis of a wide range of macromolecules including synthetic polymers. However, MAL...