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Spatially Resolved Laser Tweezers Raman Spectral Snapshots Reveal Single-Cell Molecular Heterogeneity

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Tumor heterogeneity is the major driver of cancer drug resistance, but its quantitative in situ characterization remains difficult to probe at the single-cell level. Here, laser tweezers Raman spectroscopy (LTRS) is employed to achieve micrometer-scale, spatia... ...