Enhancing the Flow Dynamics and Sensitivity of Paper-Based Lateral Flow Immunoassays Through Zwitterionic Antifouling Modification [0.03%]
Mei-Lian Yao,Fan-Chih Wen,Ya-Ting Chang et al.
Mei-Lian Yao et al.
This study achieved anti-biofouling properties for cellulose/nitrocellulose through zwitterionization, enabling more antigen to reach the detection site in lateral flow immunoassay (LFIA) technology and significantly improving sensing effic...
An Alternating Modification Strategy for Constructing l-Cys-Au Functional Interfaces in Nanochannels for Highly Selective Copper Ion Analysis [0.03%]
Saiwen Lu,Xue Dong,Jincan Yang et al.
Saiwen Lu et al.
Nanochannel-based sensors offer exceptional sensitivity, selectivity, and real-time response for ionic analysis, yet achieving advanced recognition of heavy metal ions remains challenging due to the limitations of conventional single-layer ...
Xuelian Cheng,Fensheng Qiu,Cong Cai et al.
Xuelian Cheng et al.
Aptamers, as high-affinity and high-specificity functional nucleic acids obtained through in vitro selection, face significant limitations in clinical applications due to their susceptibility to nuclease-mediated degradation in the bloodstr...
Fe-Doped Carbon Dots Functionalized Nanoelectrode for In Situ Monitoring of Metabolism-Associated ROS Changes in Single Microglia [0.03%]
Hong Jiang,Ya-Qin Wang,Xiao-Yang Dong et al.
Hong Jiang et al.
In metabolic reprogramming, reactive oxygen species (ROS) serve not only as harmful byproducts but also as essential signaling molecules that drive reprogramming processes to establish new metabolic homeostasis. Therefore, the in situ monit...
Advanced Analytical Methodologies for Monitoring Lithium in Environmental and Biological Systems for Sustainable Assessment [0.03%]
Noman Shakoor,Muhammad Adeel,Samama Tariq et al.
Noman Shakoor et al.
Graph Machine Learning Can Estimate Drug Concentrations in Whole Blood from Forensic Screening Results [0.03%]
Tetiana Lutchyn,Marie Mardal,Michael Nedahl et al.
Tetiana Lutchyn et al.
LC-HRMS is widely used in forensic toxicology for broad-scope screening. When a newly emerging or rarely encountered compound is tentatively identified, toxicologists must decide whether it may be relevant to a case and, if so, quantify it....
A Fluorescent Palladium-Ligand Platform for In Situ Monitoring and Bayesian Optimization of Sonogashira Coupling Reactions [0.03%]
Guang-Nan Xing,Teng-Ao Yang,Jun-Chen Li et al.
Guang-Nan Xing et al.
Palladium-catalyzed coupling reactions are indispensable tools for carbon-carbon bond formation, yet their optimization and real-time monitoring remain challenging in homogeneous catalytic systems. Herein, we report a multifunctional fluore...
Comparison of Liquid Chromatography- and Nano-Electrospray Ionization-Mass Spectrometry Approaches for Single-Cell Metabolomics [0.03%]
Abigail Cook,Claire Davison,Jordan Pascoe et al.
Abigail Cook et al.
Live single-cell metabolomics is a rapidly growing area of research, which offers the potential to provide unique insights into cellular function and heterogeneity. Single-cell isolation approaches based on capillary sampling are in princip...
Rapid Detection of l-Arginine Using a Fluorescent Bacillus caldovelox Arginase for Monitoring Arginase Deficiency [0.03%]
Sai-Fung Chung,Suet-Ying Tam,Paull Yik-Hing So et al.
Sai-Fung Chung et al.
Patients with arginase deficiency require lifelong treatment with pegzilarginase and regular monitoring of blood l-arginine (l-Arg) levels. To address this need, we developed a site-directed, fluorescently labeled Bacillus caldovelox argina...
Hydroxyl Radical-Activatable NIR-II Ratiometric Fluorescence Probe for Visualization In Vivo Tracking of Oxidative Stress and Therapeutic Response in Arthritis [0.03%]
Lixian Huang,Jiaqi Lu,Yidong Bin et al.
Lixian Huang et al.
Oxidative stress plays a pivotal role in the onset and progression of arthritis, in which the abnormal elevation of hydroxyl radical (•OH) has been recognized as a key molecular hallmark of early inflammation. However, effective tools capa...