Determination of Half-Maximal Inhibitory Concentration (IC50) of Drugs Using Contrast Surface Plasmon Imaging on Gold-Coated Periodic Nanowires [0.03%]
基于金涂层周期性纳米线的对比表面等离子体成像法测定药物半抑制浓度(IC50)
Hsien-San Hou,Kuang-Li Lee,Ting-Jui Tu et al.
Hsien-San Hou et al.
The half-maximal inhibitory concentration (IC50) is a critical pharmacological parameter used to quantify a drug's potency in inhibiting biological functions. In this study, we present a novel strategy to evaluate the cytotoxicity of antica...
Label-Free SERS Platform Assisted by Machine Learning for Multi-Target Detection and Physiological State Classification in Sweat [0.03%]
基于机器学习的无标签SERS平台用于汗液多目标检测及生理状态分类
Banglei Zhu,Jin Chen,Bingwei Wang et al.
Banglei Zhu et al.
The detection of sweat metabolites is crucial for health monitoring, disease screening, and personalized medicine. Traditional methods encounter challenges like low metabolite concentrations, complex biological matrices, and difficulty in a...
Paper-Based Fast-Flow Electrochemical Device Enabling Self-Calibrated and High-Throughput NADPH Measurements [0.03%]
基于纸基的快流式电化学装置实现自我校准和高通量NADPH测量
Nichakorn Thueankhum,Lalitphan Hongtanee,Usa Boonyuen et al.
Nichakorn Thueankhum et al.
Microfluidic paper-based electrochemical devices (μPEDs) are transforming cost-effective and portable diagnostics. However, conventional μPEDs are limited to a single use, as the removal of analyzed solutions is challenging, preventing re...
High-Precision Refractive Index-Based Microparticle Sorting Using Airy Beams [0.03%]
基于airy光束的高精度折射率微粒分选
Zhelin Qu,Yanan Zhang,Kunpeng Wang et al.
Zhelin Qu et al.
Precise sorting of microparticles based on their refractive indices is crucial for various applications, including hematological diagnostics, early cancer detection, and microplastic identification. Conventional imaging methods struggle to ...
Nanopipette-Based Probe Deciphering Nanoscale Charge Distribution of Graphene Layers Affecting Peptide Binding and Assembling [0.03%]
基于纳米玻璃微 pipet 的探针解析影响肽结合和组装的石墨烯层纳尺度带电分布
Jinhua Hu,Dong Wang,Ayhan Yurtsever et al.
Jinhua Hu et al.
Layered nanomaterials, such as graphite and MoS2, have attracted much attention due to the amazing electrical and optical properties of their single layers, which are useful for nanoelectronics and biosensing devices. Revealing the chemical...
A High-Sensitive and Low-Probe-Dosage Nanoprobe for Quantifying Hydrogen Peroxide Fluctuations in Physiological Pathways [0.03%]
一种高灵敏度、低探针剂量的纳米探针用于生理通路中过氧化氢波动的量化
Wenjie Zhao,Jinli Hu,Yanxia Nan et al.
Wenjie Zhao et al.
The latest research has revealed significant insights into the critical role of hydrogen peroxide (H2O2) signaling pathways. However, during the detection process, certain probes necessitate micromolar concentrations to achieve effective im...
Organic Photoelectrochemical Transistor/Visual Sensing Platform Based on CS/MCS Schottky Heterojunction and CRISPR/Cas12a-Driven Triple-Modal Synergistic Signal Amplification [0.03%]
基于CS/MCS肖特基异质结的有机光电子化学晶体管/视觉传感平台及CRISPR/Cas12a驱动的三模协同信号放大技术
Feixue Sun,Renjie Mao,Jiajing Li et al.
Feixue Sun et al.
Developing novel signal amplification and transduction technologies is the key to overcoming the bottlenecks of high-sensitivity and on-site detection in nucleic acid analysis. In this study, a dual-mode sensing platform based on organic el...
Optimized De Novo Molecular Generation (OMG) for Mass Spectra Annotation Using Transfer and Reinforcement Learning [0.03%]
基于迁移和强化学习的优化从头分子生成（OMG）方法在质谱注释中的应用
Margaret R Martin,Soha Hassoun
Margaret R Martin
Despite the size increase in spectral reference libraries and available annotation tools, the rate of assigning molecular structures to tandem mass spectra remains low. As not all chemical products are known nor cataloged in databases, gene...
Improved Mass Analysis of Proteins and Protein Complexes Present in Common Biological Buffers and Physiological Concentrations of NaCl Using Solution Additives Delivered by Theta Emitters [0.03%]
利用theta发射体输送的溶液添加剂改进在常见生物缓冲液和NaCl生理浓度下蛋白质及蛋白复合物的质量分析
Erick G Báez Bolívar,Scott A McLuckey
Erick G Báez Bolívar
Native electrospray ionization-mass spectrometry (ESI-MS) is inherently susceptible to nonvolatile salts in solution, due to ion formation resulting from the so-called "charged-residue mechanism" (CRM). The presence of nonvolatile salts lea...
An Integrated Digital Microfluidic Platform with Titanium Dioxide Nanoparticles-Assisted Laser Desorption Ionization Mass Spectrometry for Microbial Analysis [0.03%]
一种集成数字微流控平台用于微生物分析，具有钛 dioxide 纳米粒子辅助激光解吸电离飞行时间质谱功能
Boyu Li,Hang Li,Chao Yang et al.
Boyu Li et al.
Digital microfluidics (DMF) offers flexible manipulation of discrete droplets, enabling efficient sample processing and integration with various analytical techniques such as mass spectrometry (MS). While recent efforts have been dedicated ...