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Integrated Low-Speed Isolation and Ultrasensitive In-Situ Detection of Glioblastoma EVs via UiO-66-NH2@Au Nanocomposite with Temperature Synergistic Membrane Fusion and Y-EXPAR Assay

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Extracellular vesicles (EVs) secreted by glioblastoma (GBM) cells carry tumor-specific biomarkers such as microRNA-1246 (miR-1246), offering significant potential for noninvasive GBM detection. However, the efficient isolation of EVs from complex biofluids and... ...