Quantifying Hydrogen Populations in Liquid Mixtures Using 1H NMR Relaxometry [0.03%]
利用¹H核磁共振弛豫法测定液态混合物中的氢群体数量
Pallavi Guha Biswas,Marc B Taraban,Katharine T Briggs et al.
Pallavi Guha Biswas et al.
The fractions of hydrogen populations in various liquid mixtures, including liquid drug products, were quantified using time-domain 1H NMR relaxometry. Different hydrogens in a liquid mixture have different 1H transverse relaxation rates R2...
A "Space-for-Time" Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment [0.03%]
基于单细胞双同位素ICP-MS分析的“以时间换空间”策略，实现乳腺癌细胞中miRNA高通量和敏感定量以评估治疗效果
Meijun Liu,Xing Wei,Yanan Wei et al.
Meijun Liu et al.
miRNAs regulate cancer progression and serve as both biomarkers and therapeutic targets in chemotherapy and gene therapy. Current analytical platforms lack the capacity to concurrently satisfy single-cell resolution and target specificity w...
AIRPred: A Deep Learning Model Predictor for Peptide Intensity Ratios in Cross-Linking Mass Spectrometry Improves Cross-Link Spectrum Matching [0.03%]
一种深度学习模型AIRPred可预测交联质谱中的肽强度比，从而改善交联光谱匹配
Zehong Zhang,Mei Wu,Max Ruwolt et al.
Zehong Zhang et al.
Cross-linking mass spectrometry (XL-MS) is a powerful tool in structural proteomics, offering insights into protein conformations, interactions and dynamics by linking spatially proximal residues. However, current cross-linked spectrum matc...
Batch Synthesis of C@Pt Nanowires for Assembly of Reproducible Nanosensors for Intracellular Detection [0.03%]
用于细胞内检测的可再现型纳米传感器组装的C@Pt纳米线批量合成
Li-Jun Wang,Yu-Ting Qi,Xiao-Ke Yang et al.
Li-Jun Wang et al.
Electrochemical nanosensors with high spatiotemporal resolution are important tools for single-cell analysis. However, it remains a great challenge to prepare electrochemical nanosensors with excellent and highly reproducible performance. H...
An Analytical Model of Sorption-Induced Static Mode Nanomechanical Sensing for Multicomponent Analytes [0.03%]
一种用于多组分分析物的吸附诱导静态模式纳米力学传感的分析模型
Kosuke Minami,Genki Yoshikawa
Kosuke Minami
Nanomechanical sensors and their arrays have attracted significant attention for detecting, distinguishing, and identifying target analytes, especially complex mixtures of odors. In the static mode operation, sensing signals are obtained by...
Functional Raman Probes for Detecting Enzyme Activities Based on Aggregation Control [0.03%]
基于聚集控制的用于检测酶活性的功能型拉曼探针
Momoko Okinaka,Minoru Kawatani,Hiroyoshi Fujioka et al.
Momoko Okinaka et al.
Visualizing specific enzyme activities in living systems is important in biomedical research, and Raman imaging probes are particularly suitable for simultaneous multiplexed detection of plural enzyme activities due to their narrow signal p...
QC4Metabolomics: Real-Time and Retrospective Quality Control of Metabolomics Data [0.03%]
QC4代谢组学：代谢组数据的实时和回顾性质量控制
Jan Stanstrup,Lars Ove Dragsted
Jan Stanstrup
The ability to answer complex biological questions in metabolomics relies on the acquisition of high-quality data. However, due to the complex nature of liquid chromatography-mass spectrometry acquisition, data quality checks are often not ...
Molecular Average and Intramolecular δ13C Measurements of Pyruvic Acid and Acetic Acid Using Gas Chromatography Orbitrap Mass Spectrometry (GC Orbitrap-MS) [0.03%]
基于气相色谱轨道质谱联用技术的丙酮酸和醋酸分子同位素平均值及分子内δ13C测量方法
Youki J Sato,Allison A Baczynski,Hao Xie et al.
Youki J Sato et al.
We developed a novel method using gas chromatography - Orbitrap mass spectrometry (GC Orbitrap MS) to measure the intramolecular carbon isotope value of pyruvic acid and acetic acid with high mass accuracy and mass resolution with nanomole ...
De Novo Design of Photosensitizers Activated by Tumor Microenvironments for NIR Imaging and Photodynamic Therapy of Tumor [0.03%]
用于肿瘤近红外成像和光动力治疗的活化于肿瘤微环境内的新型光敏剂的从头设计
Rongbin Zhong,Yan Hu,Jia Huang et al.
Rongbin Zhong et al.
Photodynamic therapy (PDT) has emerged as a commonly employed treatment for cancer patients. However, existing photosensitizers exhibit inadequate selectivity toward cancer cells and are susceptible to penetration depth. Herein, we de novo ...
Unveiling Radical-Based Reactions in Photochemical Vapor Generation via Online and In Situ Electron Paramagnetic Resonance Monitoring [0.03%]
基于自由基的反应在光化学蒸汽生成中的在线及原位电子顺磁共振监测下的揭露
Lu Zhang,Yuqi Li,Jing Hu et al.
Lu Zhang et al.
Photochemical vapor generation (PCVG) is an effective alternative to traditional chemical vapor generation (CVG), offering superior sample introduction and matrix separation. The mechanism of PCVG involves radical reactions initiated by pho...