Potential of Time Domain Nuclear Magnetic Resonance as a Noninvasive Method for Detection and Quantification of Protein Glycation in Biopharmaceuticals [0.03%]
时间域核磁共振技术在生物制药中非侵入性检测和定量蛋白质糖基化潜能的方法研究
Hani Alam,Ozlem Gezici Koc,Cem Yamali et al.
Hani Alam et al.
Biopharmaceuticals are an essential and growing part of modern medicine. Given their complex structure, they are prone to chemical and physical instabilities, including glycation, a nonenzymatic chemical reaction between the free amino grou...
Dielectrophoretic Slide: A Platform for Electrokinetic Characterization of Microparticles [0.03%]
介质电泳芯片：微米颗粒电动力学表征平台
Aaditya Venkatesha Babu Bangaru,Holton Shults,Stuart J Williams
Aaditya Venkatesha Babu Bangaru
Dielectrophoresis (DEP) enables label-free particle polarizability quantification via the frequency-dependent Clausius-Mossotti (CM) factor; however, experimental determination of its real component, Re[CM], typically relies on additional c...
Biomass-Derived Conductive Hydrogel-Based Electronic-Skin Patch for Integrated Wearable Bioelectronics and Real-Time Wound-Status Monitoring and Treatment [0.03%]
一种基于生物质导电水凝胶的电子皮肤贴片用于集成式可穿戴生物电子产品及伤口状态实时监测与治疗
Xugang Dang,Boyan Guo,Xuechuan Wang
Xugang Dang
Conductive hydrogel-based electronic-skin (e-skin) patches represent an emerging category of smart wound dressings, facilitating innovative approaches to chronic wound repair and real-time monitoring. Despite their advantages in biocompatib...
An "Enrichment-Detection" Electrochemiluminescence Biosensor Based on Bifunctional Nanozymes for Quantitative Detection of Exosomes with PD-L1 [0.03%]
一种基于双功能纳米酶的“富集-检测”型电化学发光生物传感器用于定量检测PD-L1阳性外泌体
Yaqi Qin,Yuling Li,Bo Shen et al.
Yaqi Qin et al.
Exosomes with high programmed death ligand 1 expression (PD-L1+ exosomes) have proven instrumental in both screening non-small cell lung cancer (NSCLC) patients and forecasting responses to immune checkpoint inhibitors (ICIs). Nonetheless, ...
High-Throughput Testing for Unknown Mutagens and Cytotoxica via Duplex Planar Ames-Cytotoxicity Bioassay Including Metabolic S9 Activation [0.03%]
一种用于未知诱变剂和细胞毒剂的高效检测方法：包括代谢S9活化的平板安梅-细胞毒性双重试验
Katharina Schmidtmann,Ann-Cathrin Kayser,Gertrud E Morlock
Katharina Schmidtmann
Current nontarget effect-directed analysis of complex samples for mutagens is hampered by matrix effects, associated cytotoxicity, diffusion effects, insufficient sensitivity, and a lack of selectivity. Non-target analysis may overlook high...
Rapid Diagnosis of Bacteremia in Febrile Pediatric Oncology Patients via Host-Response Infrared Spectroscopy of Blood and Machine Learning [0.03%]
基于血液宿主响应红外光谱和机器学习的儿科肿瘤发热患者快速诊断菌血症的方法
Yotam D Eshel,Uraib Sharaha,Dima Bykhovsky et al.
Yotam D Eshel et al.
Bacteremia is a life-threatening complication and a leading cause of sepsis and septic shock in patients. Conventional diagnostic methods, such as blood culture, remain the clinical gold standard but require 24-72 h, often necessitating the...
Correction to "Exploration of Semiconductor Chip-Based Single-Molecule Protein Sequencing for Identification of Hemoglobin Variants" [0.03%]
“基于半导体芯片的单分子蛋白质测序鉴定血红蛋白变异型的研究”的纠正项
Ruben Y Luo,Mathivanan Chinnaraj,Kristin Blacklock et al.
Ruben Y Luo et al.
Published Erratum
Analytical chemistry. 2026 Mar 2. DOI:10.1021/acs.analchem.6c01120 2026
One-Pot O-Glycan Release and Permethylation (OPORP) Enables Rapid and Quantitative O-Glycan Analysis from Low-Input Samples [0.03%]
一步O-糖链释放和 permethylation（OPORP）使低输入样品的O-糖链实现快速定量分析
Shuhong Guo,Nafisa Tursumamat,Shengyang Liu et al.
Shuhong Guo et al.
O-glycosylation, an exceptionally complex and heterogeneous post-translational modification, plays pivotal roles in diverse biological and pathological processes, and is a key regulator of biopharmaceutical quality and efficacy. However, th...
Narrow-Window Cathodic Electrochemiluminescence from Laser-Engineered Graphitic Carbon Nitride: A Next-Generation Emitter for Microplastics Biosensing [0.03%]
激光工程石墨氮化碳的窄窗口阴极电致化学发光：微塑料生物传感的下一代发射器
Ying Hou,Yueyuan Li,Xuejing Liu et al.
Ying Hou et al.
The accuracy of anode electrochemiluminescence (ECL)-based microplastic detection in seawater is undermined by ubiquitous reducing agents. These substances quench the signal by both competing for electrons with the emitter and coreactant to...
Studying Collagen Architecture in Solution by Raman Optical Activity Spectroscopy [0.03%]
拉曼光学活性光谱法在溶液中研究胶原蛋白结构
Jiří Kessler,Jaroslav Šebestík,Martin Šafařík et al.
Jiří Kessler et al.
Raman and Raman optical activity (ROA) spectroscopy provide a unique insight into the three-dimensional structure of biomacromolecules; however, it is often hampered by low sensitivity, low resolution, and the lack of theoretical models. To...