Label-Free Raman Spectral Identification of NK and NKT Cells in Immune Heterogeneous Cell Populations [0.03%]
免疫异质细胞群中NK和NKT细胞的无标签拉曼光谱鉴定法
Jianhui Wan,Shuang Zhang,Weina Zhang et al.
Jianhui Wan et al.
NK and NKT cells act as major effector subsets across multiple immune heterogeneous cell populations (HCPs), and their precise identification is essential for assessing product quality and predicting clinical efficacy. Here, we present a la...
ReCQC: A Novel NMR Data Analysis Platform Leveraging 13C NMR and HSQC Database Strategies for Natural Product Dereplication [0.03%]
一种新型的NMR数据分析平台ReCQC：利用¹³C NMR和HSQC数据库策略进行天然产物脱重复分析
Tingcai Dong,Shengqi Zhang,Yongfan Zi et al.
Tingcai Dong et al.
Leveraging 13C NMR spectroscopic data, in this study, an innovative methodology is proposed for the efficient and accurate elucidation of the skeletal structures of target components within complex mixtures through the identification of max...
Advances in Analysis of Therapeutic Oligonucleotides with Chromatography Coupled to Mass Spectrometry [0.03%]
色谱-质谱联用技术在寡核苷酸治疗药物分析中的研究进展
Sandy Al Bardawil,Philippe Barthélémy,Ludivine Ferey
Sandy Al Bardawil
A Near-infrared Fluorescence Probe with Photothermal-Assisted BBB Penetration for Enhanced Brain Imaging of α-Synuclein Aggregates [0.03%]
一种近红外荧光探针，利用光热增强的血脑屏障渗透功能，用于增强α-突触核蛋白聚集物的大脑成像技术
Wan-Chun Luo,Shengbo Kang,Lina Bao et al.
Wan-Chun Luo et al.
Accurate in vivo imaging of pathological α-synuclein (α-syn) aggregates is crucial for the diagnosis and mechanistic study of synucleinopathies. In this study, we report a series of chalcone-based fluorescence probes (11-13) with tunable ...
Quantum Well-Enhanced Plasmonic Substrate to Enhance Spontaneously Blinking Fluorescence for Single-Molecule Localization Microscopy [0.03%]
量子阱增强等离激元基底提升单分子定位显微镜中原位荧光闪烁效应
Shang-En Hsieh,Jian-Zong Lai,Kun-Yu Lai et al.
Shang-En Hsieh et al.
Quantum well (QW)-enhanced plasmonic substrates have been demonstrated to improve the blinking fluorescence of spontaneously blinking fluorophores, which enhances the localization precision and density for single-molecule localization micro...
Robust Rapid Cellular Metabolite Sensing Using Benchtop NMR and SABRE-Hyperpolarized [1-13C]Pyruvate [0.03%]
利用台式NMR和SABRE-极化[1-13C]乳酸的稳健快速细胞代谢检测技术
Joseph Gyesi,Patrick TomHon,Abubakar Abdurraheem et al.
Joseph Gyesi et al.
Hyperpolarized NMR has emerged as a powerful analytical technique to significantly enhance targeted NMR signals, improving the sensitivity for investigations of unique chemical and biological dynamics. Here, we demonstrate the use of a hype...
Harnessing X-ray-Induced NIR-II Afterglow through ROS-Mediated Molecular Activation for Tumor Radiotheranostics [0.03%]
通过ROS介导的分子活化调控X射线诱导的近红外二区余晖用于肿瘤放疗诊疗
Jining Qin,Binlong Zhang,Kang Zhu et al.
Jining Qin et al.
Organic afterglow probes activated by X-rays hold considerable potential for deep-tissue imaging and cancer therapy. However, their applications are often limited by short-wavelength emission and the inefficient X-ray-induced generation of ...
Position-Specific Carbon Isotope Fingerprinting of Fluorinated Organics and Degradation Products [0.03%]
含氟有機物及其降解產物的位點特徵碳同位素指紋識別技术
Cornelia Rasmussen,David W Hoffman
Cornelia Rasmussen
Fluorinated organic compounds are of growing environmental and forensic relevance due to their widespread use in pharmaceuticals, agrochemicals, and consumer products, their environmental persistence, and potential ecological and human heal...
Integrated and Ultrafast Multiomics Sample Preparation Workflow for Screening Biomarker Panel of Platelet Biomolecules for Early Diagnosis of HCC [0.03%]
用于筛查血小板生物分子标志物以实现肝癌早期诊断的集成超快速多组学样品制备流程
Fenglin Shen,Yang Liu,Xuelian Ruan et al.
Fenglin Shen et al.
Early detection of hepatocellular carcinoma (HCC) remains a persistent worldwide challenge. Owing to its minimal invasiveness, liquid biopsy has emerged as a promising alternative for early screening. As key components of the tumor microenv...
Multimodal Serum Profiling for Early Detection and Risk Assessment of Oral Potentially Malignant Disorders and Oral Cancer [0.03%]
用于口腔潜在恶性病变和口腔癌的早期诊断和风险评估的多模态血清蛋白谱分析
Panchali Saha,Ronak Varyani,Arti Hole et al.
Panchali Saha et al.
Oral squamous cell carcinoma (OSCC) has high incidence rates in India, with poor survival rates due to late diagnosis. Oral potentially malignant disorders (OPMDs) such as leukoplakia (L) and oral submucous fibrosis (OSMF) present a critica...