Real-Time Monitoring Supramolecular Disassembly by Nanoconfinement Engineering-Tuned Electrochemiluminescence [0.03%]
通过纳米限域工程调控的电化学发光实时监测超分子解组装
Qianxi Duan,Jingke Pan,Yunxiu Jia et al.
Qianxi Duan et al.
Understanding the disassembly process is significant for constructing well-defined and multifunctional supramolecular structures. Nowadays, fluorescent microscopy is used as a common technique to observe a real-time disassembly process. How...
PET-Cantilever-Enhanced Fiber-Optic Photoacoustic Spectroscopy for Rapid Subppm Methane Detection [0.03%]
基于PET悬臂增强的光纤Photoacoustic光谱法实现快速的亚ppm级甲烷检测
Guojie Wu,Yuchen Guan,Xubin Li et al.
Guojie Wu et al.
To address the challenges of low sensitivity and poor stability in conventional single-fiber photoacoustic spectroscopy, here, we present for the first time a polyethylene terephthalate (PET)-cantilever-enhanced fiber-optic photoacoustic sp...
Rational Design and Synthesis of Peptide-Based Probes for Fibroblast Activation Protein-Targeted Magnetic Resonance and NIR-I/II Fluorescence Imaging of Cancer-Associated Fibroblasts [0.03%]
合理设计并合成基于肽的探针用于磁共振及近红外荧光成像技术下的纤维活化蛋白靶向成像以观测与癌症相关的成纤维细胞
Xiaoyu Wang,Rongfeng Zou,Ningxin Yang et al.
Xiaoyu Wang et al.
Cancer-associated fibroblasts (CAFs), characterized by the expression of fibroblast activation protein (FAP), play a pivotal role in tumor progression and therapy resistance. FAP-targeted molecular imaging offers a powerful tool for the pre...
Evaluation of a New Chemical Label BASA: A Comparison with Gold Standards [0.03%]
新型化学标记BASA的评估与金标准对比研究
Jérémy Monteiro,Karen Ple,Antoine Lefèvre et al.
Jérémy Monteiro et al.
Personalized medicine involves tailoring medical treatments to the unique characteristics of each individual. For example, genomic insights enable precise diagnoses and targeted therapies in oncology. However, significant challenges remain ...
Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma [0.03%]
胶质母细胞瘤内肿瘤细菌靶向级联响应声致余晖纳米探针用于免疫重编程和可视化
Yanping Jiang,Jiawei Zhang,Jingjing Ye et al.
Yanping Jiang et al.
Bacteria within glioblastoma (GBM) promote tumor progression and immunosuppression, while current treatments face challenges such as poor blood-brain barrier (BBB) penetration and immunosuppressive macrophages. To overcome these, we develop...
Nanocomposite Indicator-Based High-Resolution Naked-Eye Hue Sensor for Catecholamine Detection [0.03%]
用于检测儿茶酚胺的纳米复合材料指示剂基高分辨率裸眼色调传感器
Caiping Ding,Weiwei Chen,Ruomei Teng et al.
Caiping Ding et al.
Naked-eye sensing in monochromatic systems is inherently limited in accuracy due to the subjective interpretation of subtle color changes, particularly in catecholamine detection. To address this challenge, we developed a high-resolution mu...
Phage Cell Wall Binding Domain for Gram-Negative Bacteria and Its Application in Detection of Acinetobacter baumannii [0.03%]
一种用于革兰氏阴性菌噬菌体细胞壁结合结构域及其在铜绿假单胞菌检测中的应用
Chong Yu,Honglin Yang,Essam A M S Obaid et al.
Chong Yu et al.
The cell wall binding domain (CBD) of endolysin plays an irreplaceable role in the propagation cycle of phages as it can specifically bind with the cell wall of target bacteria. Although it is a promising agent for recognizing bacteria, thi...
Seamless Tiling and Scalable Coherent Raman Spectroscopic Analysis Reveals Developmental Maturation of Lipids in the Mouse Brain [0.03%]
无缝马赛克和可扩展的相干拉曼光谱分析揭示了小鼠大脑脂质发育成熟的情况
Minori Masaki,Yusuke Murakami,Zuliang Hu et al.
Minori Masaki et al.
Lipids constitute approximately half of the dry weight of the brain and play a crucial role in the rapid conduction of action potentials and neurotransmission. However, the maturation of the lipid composition underlying complex brain functi...
Soft Independent Modeling of Class Analogies for the Screening of New Psychoactive Substances through UPLC-HRMS/MS [0.03%]
用于通过UPLC-HRMS/MS筛查新精神活性物质的类比类别软独立建模方法
Ilenia Bracaglia,Sara Gamberoni,Camilla Montesano et al.
Ilenia Bracaglia et al.
The proliferation of NPS has become a global issue, due to their easy availability and ability to bypass drug screening tests. These substances are particularly concerning because of their unpredictable toxicological effects and the analyti...
Development of a Femtosensitive Electrochemical Aptasensor for Tuberculosis Ag85B Detection [0.03%]
一种用于检测结核分枝杆菌Ag85B蛋白的飞摩尔级电化学生物传感器的研究与发展
Shraddha Chauhan,Jeong Wook Lee
Shraddha Chauhan
Tuberculosis (TB) disease continues to pose a major global health challenge, particularly in resource-limited settings where access to rapid, sensitive, and affordable diagnostic tools remains limited. Traditional methods, such as sputum sm...