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A Near-infrared Fluorescence Probe with Photothermal-Assisted BBB Penetration for Enhanced Brain Imaging of α-Synuclein Aggregates

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Accurate in vivo imaging of pathological α-synuclein (α-syn) aggregates is crucial for the diagnosis and mechanistic study of synucleinopathies. In this study, we report a series of chalcone-based fluorescence probes (11-13) with tunable π-bridges, among wh... ...