Gap-Controlled Infrared Absorption Spectroscopy: A Unique Interface-Sensitive Spectroscopy Based on the Combination of Linear Spectroscopy and Multivariate Curve Resolution [0.03%]
间隙控制型红外吸收光谱法：一种基于线性光谱与多变量曲线解析结合的独特的界面敏感型光谱方法
Shoichi Maeda,Shunta Chikami,Subin Song et al.
Shoichi Maeda et al.
We present an interface-sensitive spectroscopy method that integrates attenuated total reflection infrared absorption (ATR-IR) spectroscopy, a distance control system, and multivariate curve resolution (MCR). In this approach, we adjust the...
Ultra-Sensitive Near-Infrared Imaging of Micro-Neuroinflammation with Surface-Engineered Silver Indium Selenide Quantum Dots [0.03%]
基于表面改性的银铟硒量子点的超高灵敏近红外微炎症成像研究
Wanru Tian,Xin Zhao,Yao Li et al.
Wanru Tian et al.
Encephalitis, a severe inflammatory brain condition, poses significant diagnostic challenges due to its heterogeneous symptoms and the limitations of conventional imaging techniques, such as magnetic resonance imaging (MRI), which often fai...
The Impact of Rare Adsorption Site Clustering on Peak Broadening in Chromatography [0.03%]
吸附位点聚集对色谱峰展宽的影响
Nikita Kovalenko,Christy F Landes
Nikita Kovalenko
Peak broadening is one of the most important phenomena in chromatography, leading to a decrease in the separation efficiency. It is well-known that the presence of rare sites on the adsorption surface, which have different kinetic character...
Supervised Contrastive Learning Leads to More Reasonable Spectral Embeddings [0.03%]
监督对比学习导致更合理的光谱嵌入
Peng Xiong,Hongtao Xu,Haoran Zheng
Peng Xiong
Over the past decades, mass spectrometry has served as a fundamental technique for molecular identification in the field of metabolomics, widely applied to the analysis and characterization of biomolecules. However, the complexity of experi...
rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data [0.03%]
rtmsEcho：一个用于声发射质谱数据自动分析的开源R包
Mary Ashley Rimmer,Nathaniel Twarog,Tharindu A Ranathunge et al.
Mary Ashley Rimmer et al.
Mass spectrometry (MS) is a well-established technology in biological research, enabling the sensitive and precise quantitative analysis of complex samples. While traditional LC-MS systems provide robust performance for targeted analyses, t...
A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors [0.03%]
利用LiP-MS和分子动力学模拟进行化合物库筛选的命中优先级策略及其在KRas G12D抑制剂中的应用
Foroughsadat Absar,Brandon Novy,Edith Nagy et al.
Foroughsadat Absar et al.
An important step in screening small-molecule libraries for drug discovery is hit prioritization and validation in order to rule out false positives. This is usually performed using biochemical and biophysical assays, so the development of ...
Coupling Drift Tube Ion Mobility Measurements with Charge Detection Mass Spectrometry for the Analysis of Virus-like Particles and Other Megadalton-Sized Ions [0.03%]
结合漂移管离子淌度测量和电荷检测质谱分析病毒样颗粒及其他兆达拉顿大小的离子
David W Reitenbach,Raj A Parikh,Minh T Ha et al.
David W Reitenbach et al.
The coupling of ion mobility (IM) measurements and mass spectrometry (IM-MS) has provided valuable structural information for gas phase ions and helped to resolve complex mixtures. However, the mass range of conventional MS is limited by th...
Peptide-Conjugated Dual-Photoelectrode Platform for Enhanced Anti-Interference Photoelectrochemical Cytosensing [0.03%]
用于增强型抗干扰光电化学细胞传感的肽连接双光电极平台
Ying Zhao,Yaqun Xu,Wei Li et al.
Ying Zhao et al.
Accurate probing of circulating tumor cells (CTCs) is critical for early cancer diagnosis and effective clinical intervention. However, achieving reliable cytosensing in complex biological fluids remains an arduous endeavor due to issues su...
CRISPR/Cas13a trans- Cleavage-Driven Programmable Autonomous Synthesis of a Functional G-Quadruplex for Ultrasensitive Detection of Circular RNAs with an Improved Signal-to-Background Ratio [0.03%]
基于CRISPR/Cas13a介导的高效级联转切割反应的环状RNA超灵敏检测技术
Wen-Jing Liu,Junzhi Liu,Fei Ma et al.
Wen-Jing Liu et al.
Circular RNAs (circRNAs) are a prevalent class of endogenous RNAs that regulate gene expression in various biological pathways, and their dysregulation is closely linked to tumorigenesis. Herein, we demonstrate the CRISPR/Cas13a trans-cleav...
A Dual-Enhancement Fiber-Optic Photoacoustic Spectroscopy Sensor Based on a Spherical-Cylindrical Coupled Resonator with an Integrated Multipass Cell for Sub-ppb C2H2 Detection [0.03%]
基于集成多程池的球柱耦合谐振腔的双增强型光纤光声光谱传感器用于 ppb 级乙炔气体检测
Guojie Wu,Yuchen Guan,Jing Jiang et al.
Guojie Wu et al.
Although conventional spherical resonators are effective for photoacoustic spectroscopy (PAS), their sensitivities are fundamentally limited because the required detection apertures disrupt the optimal acoustic resonance. To address this li...