Stereoisomeric Separation of Flavonoids by Two-Dimensional Supercritical Fluid Chromatography: Identification of Adequate Chiral Columns and Application to Honey Analysis [0.03%]
手性蜂蜜中茋类茋的手性分离-用于蜂蜜分析的适当手性柱和二维超临界流体色谱法应用研究
Laurine Réset,Bibi Ousseni,Mélodie Degrelle et al.
Laurine Réset et al.
Chiral flavonoids are frequently encountered in natural products consumed as food or therapeutic products. However, the taste and other bioactivities of stereoisomers are known to differ. Hence, stereoseparation methods are necessary to res...
Enantioseparation and Determination for Racemate Carnitine Based on a Chiral Hybrid Material Synthesized by Metal Organic Framework and Covalent Organic Framework in Capillary Electrochromatography [0.03%]
基于金属有机框架和共价有机框架手性杂化材料的卡尼丁外消旋体的手性分离与测定capillary electrochromatography中的应用研究
Jiawen Yu,Lidi Gao,Xinran Qu et al.
Jiawen Yu et al.
In this work, a CDs-TpBD/UiO-66 hybrid material was firstly synthesized via Schiff base reaction using isocyanate-β-cyclodextrin (CDs) as a chiral modifier, TpBD COF and UiO-66-NH2 MOF as the frameworks, and was characterized by Fourier-tr...
Advances in Selective Bioactivity and Toxicity of Chiral Triazole Fungicides and Their Selective Behavior in Mammals [0.03%]
手性三唑杀菌剂的选择性生物活性、毒性和对哺乳动物的选择性行为研究进展
Nan Wang,Yuhui Liu,Jianxin Li et al.
Nan Wang et al.
As one of the most widely used fungicides in global agriculture, chiral triazole fungicides play a crucial role in crop protection due to their broad-spectrum efficacy. However, the environmental problems caused by their widespread use are ...
BINOL-3,3'-Dicarboxylic Acid: Resolution for the Key Intermediate of (S)-bepotastine [0.03%]
(S)-befotastine关键中间体 BINOL-3,3'-二羧酸的拆分研究
So-Yeon Nam,Koteswara Rao Kamma,Joungmo Cho et al.
So-Yeon Nam et al.
(S)-Bepotastine is a highly selective histamine H1-receptor antagonist in the treatment of allergic rhinitis and other allergic diseases. We achieved a facile and convenient synthesis of (S)-bepotastine by resolving an early stage synthetic...
Cross-Catalysis and Weak Interactions: Keys to the Chiral Polarization of the Biosphere [0.03%]
交叉催化与弱相互作用：生命系统手性分化的关键因素
Sergey V Stovbun,Aleksey A Skoblin,Dmitry V Zlenko
Sergey V Stovbun
Molecular homochirality - the uniformity of chirality in biological molecules - is a fundamental feature of life, yet its origins remain unresolved. The correspondence between the chirality of biological monomers on Earth and that observed ...
Time-Dependent Resolution of an Atropisomeric 1-Arylpyrrole by a Novel 1-Arylethylamine Saltforming Agent [0.03%]
新型1-芳乙胺盐形成剂对一种联苯吡咯类异构体的时间分辨效应研究
Hong Ha Thuy Nguyen,Erika Bálint,Béla Mátravölgyi
Hong Ha Thuy Nguyen
This study represents a special, time-dependent resolution strategy of an atropisomeric, bifunctional 1-phenylpyrrole derivative, using the nonactive enantiomer of the key amine intermediate Apremilast as an efficient resolving agent. Among...
Gianluigi Albano,Gennaro Pescitelli
Gianluigi Albano
A recent publication by Kopec et al., "The effect of enantiomers of thalidomide on colon cells-Raman spectroscopy studies", reported to "demonstrate that Raman spectroscopy reveals distinct spectral differences between the enantiomers of th...
A Robust HPLC Method for the Simultaneous Determination of Finerenone and Its Enantiomer Using AQbD [0.03%]
基于AQbD的手性衍生化高效液相色谱法拆分分离芬戈莫德对映异构体及其同时测定方法学研究
Badriah Saad Al-Farhan,Ghada M G Eldin
Badriah Saad Al-Farhan
The enantiomeric purity of Finerenone (FIN), a novel therapeutic for chronic kidney disease (CKD), is a critical quality attribute for ensuring patient safety. This study reports the first chiral HPLC method for the simultaneous determinati...
Spectroscopic Study of R- and S-Ketoprofen Inclusion Complexes With 2-Hydroxypropyl-β-cyclodextrin [0.03%]
手性和消旋酮洛芬与羟丙基-β-环糊精包合物的光谱研究
Asma Obaid,Nujud Maslamani,Ameerah Theqah et al.
Asma Obaid et al.
Ketoprofen, also known as (RS)-2-(3-benzoylphenyl)-propionic acid, has the molecular formula C16H14O3 and is classified as a non-steroidal anti-inflammatory medication. R-ketoprofen has stronger analgesic effects than S-K, and as a result, ...
Variations in the Optical Activity of L-Arginine in Electrolyte and Nonelectrolyte Solutions [0.03%]
L-精氨酸在电解质和非电解质溶液中的光学活性变化规律研究
Joong-Won Shin
Joong-Won Shin
Specific rotations [α] of L-arginine in water and aqueous solutions of glycine, HCl, LiCl, KCl, NaOH, and Na2SO4 were measured at 405 nm. The [α] value is 34.7 ± 0.5 deg·mL·dm-1·g-1 in water and increases with the increasing acidity i...