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BINOL-3,3'-Dicarboxylic Acid: Resolution for the Key Intermediate of (S)-bepotastine

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(S)-Bepotastine is a highly selective histamine H1-receptor antagonist in the treatment of allergic rhinitis and other allergic diseases. We achieved a facile and convenient synthesis of (S)-bepotastine by resolving an early stage synthetic precursor. We devis... ...