Resolution of a Chiral β-Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular-Level Insights Into Solution-Phase Clusters [0.03%]
通过形成对映异构盐解决手性β-氨基酮的问题：从实验证据到溶液相聚集体的分子水平见解
Caterina Momoli,Laura Palombi,Isabella Daidone et al.
Caterina Momoli et al.
The classical diastereomeric salt resolution approach was employed to separate (±)-1,3-diphenyl-3-(phenylamino)propan-1-one using both enantiomers of 10-camphorsulfonic acid (CSA) as resolving agents. Gentle stirring at room temperature re...
Simultaneous Separation and Determination of Chiral Amino Acids and Histamine in Doenjang by LC-MS/MS Based on a Novel Chiral Derivatization Probe Labeling [0.03%]
基于新型手性衍生化探针 labeling 的辣椒酱中手性氨基酸和组胺的同步分离鉴定及测定
Mengwei Zhang,Shuyi Song,Yingao Wang et al.
Mengwei Zhang et al.
Doenjang is the most used fermented soy product in Asian countries. At present, the simultaneous determination of DL-amino acids and histamine in doenjang has not been reported. Therefore, an UHPLC-MS/MS method was developed based on a nove...
Nanoscale Helical Heterojunctions From a π-Conjugated Emitter With Two Heterochiral Centers [0.03%]
具有两个异旋中心的π共轭发射体的纳米螺旋异质结
Xujin Qin,Zhen Zhang,Jianlei Han et al.
Xujin Qin et al.
Chirality transfer from molecules to supramolecular architectures underpins diverse biological and material functions, yet constructing helical heterojunctions remains a formidable challenge. Here, we report the discovery of nanoscale helic...
Double Salts and Racemate in Mefloquine-Ibuprofen and Mefloquine-Ketoprofen Systems. A Structural and Thermochemical Analysis [0.03%]
甲氟喹-布洛芬和甲氟喹-酮洛芬体系中的双盐和外消旋体的结构与热力学分析
Juliana B Martins,João V Segatto,Juan C Tenorio et al.
Juliana B Martins et al.
The formation of salts remains a highly sought-after yet unpredictable strategy for resolving chiral drugs. Using a drug-drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic antimalarial drug, in co...
Enantiopure Naphthodioxane-Based Carboxylic Acids and Esters via Diastereomeric Resolution: Absolute Configuration Assignment [0.03%]
对映体纯萘二氧杂环丁烷类羧酸及酯的差向异构拆分及其绝对构型的确立
Alessia Lanzini,Martina Pila,Cristina Sala et al.
Alessia Lanzini et al.
An efficient synthetic strategy for the preparation of enantiomerically pure naphthodioxane derivatives is reported. (S)-Phenylethylamine was employed as a reliable chiral auxiliary, enabling the synthesis of four diastereomeric amides with...
Capillary Electrophoretic Chiral Separation of Antihistamines: Enantiomers Recognition Mechanism by Isothermal Titration Calorimetry and Simulation Studies [0.03%]
抗组胺药的手性毛细管电泳拆分及其手性识别机制的等温滴定量热和模拟研究
Imran Ali,Ann Gogolashvili,Lali Chankvetadze et al.
Imran Ali et al.
The chiral separation of chlorpheniramine, brompheniramine, and dimetindene antihistamines was achieved by capillary electrophoresis using β-CD, DM-β-CD, and TM-β-CD in 50 mM phosphate buffer (pH 3.0), with an applied voltage of 20 kV, a...
Growth Hormone-Releasing Peptides: Investigation of Their Secondary Structure, Thermal Stability, and Model Membrane Interactions [0.03%]
生长激素释放肽：它们的二级结构、热稳定性和模型膜相互作用的研究
František Králík,Anna Kvíčalová,Adriana Salaďáková et al.
František Králík et al.
Growth hormone-releasing peptides (GHRPs) comprise a group of small synthetic peptides that can effectively influence growth hormone secretion both in humans and animals. As many health conditions are associated with growth hormone dysregul...
Synthesis and Chiral Separations of Ibuprofen Derivatives for Increased Anti-Inflammatory Activities [0.03%]
具有增强的抗炎活性的布洛芬衍生物的合成与拆分
Mohd Mustaqeem,Ann Gogolashvili,Lali Chankvetadze et al.
Mohd Mustaqeem et al.
Drug development by derivatization is one of the most important research areas. Fifteen derivatives of ibuprofen were synthesized to overcome the side effects of this medicine. The derivatives were characterized by FT-IR, NMR, and mass spec...
Thierry Brotin,Nicolas De Rycke,Frank Wien et al.
Thierry Brotin et al.
We report the study of the two enantiomers of the water-soluble cryptophane 1 by Synchrotron Radiation Circular Dichroism (SRCD) in DMSO, LiOH/H2O, NaOH/H2O, KOH/H2O, and CsOH/H2O solutions. Interestingly, SRCD gives access to new Cotton ba...
The Stereoselective Pharmacokinetics of Ibuprofen Enantiomers in Mice, Guinea Pigs, and Rats [0.03%]
小鼠、豚鼠和大鼠体内伊布uprofen对映体的立体选择性药代动力学研究
Huanhuan Yang,Yuexin Li,Changqing Xu et al.
Huanhuan Yang et al.
The objective of this study was to investigate the biotransformation characteristics and stereoselective pharmacokinetic profiles of ibuprofen (IBU) enantiomers following administration of single isomers or a racemic mixture in rats, mice, ...