Control of Chiroptical Properties on Chiral Phosphangulenes Having Azobenzene Moieties by Photoirradiation Based on Synergistic Exciton Coupling [0.03%]
基于协同 exciton 偶合的光照射对偶氮苯取代的手性磷杂戊轮光学活性的控制
Masaki Yamamura,Kazu Nin,Tatsuya Nabeshima
Masaki Yamamura
C3-symmetric phosphangulene derivatives feature planar chirality with high inversion barrier due to the phosphorus atom. Chiral phosphangulenes have been extensively studied in recent years and have been reported to show exceptionally chara...
Asymmetric Synthesis and Antibacterial Evaluation of β-Substituted (S)-α-Alanine Analogs Containing a Piperazine Moiety in the Side Chain [0.03%]
含侧链哌嗪结构的β-取代(S)-α-氨基酸类似物的不对称合成及抗菌活性研究
Emma A Khachatryan,Anna F Mkrtchyan,Anahit M Hovhannisyan et al.
Emma A Khachatryan et al.
A series of novel enantiomerically enriched α-amino acids containing piperazine fragments were synthesized via nucleophilic addition of piperazine derivatives (2a-d) to the C = C bond of a square-planar Ni (II) complex of the Schiff base d...
Synthesis and Photophysical Properties of Chiral Diaminodicyanoquinodimethane: Formation Mechanism and Chiroptical Properties [0.03%]
手性二氨基二氰基喹二甲烷的合成及光物理性质：形成机制及圆二色谱性质研究
Aslınur Gokpinar,Perihan Ozturk,Duygu Tan et al.
Aslınur Gokpinar et al.
Chirality is fundamental to biological systems and the pharmaceutical industry, yet efficient methods for determining the absolute configuration of chiral compounds remain a challenge. This study reports the synthesis and characterization o...
Cyclodextrin Metal-Organic Framework With Amino Acid Chiral Ligands for Capillary Electrochromatographic Enantioseparation [0.03%]
手性氨基酸配体金属有机框架材料的制备及其毛细管电色谱拆分应用研究
Xiaozhen Shao,Guangfu Xu,Jiaquan Chen et al.
Xiaozhen Shao et al.
Metal-organic frameworks (MOFs) are widely used in the field of chromatographic separation due to their unique properties. A vapor diffusion method was used to synthesize the cyclodextrin MOF (CD-MOF) with D-histidine (D-His) as a chiral li...
Chiral Organometallic Atropoisomers of the Type [Ru(η6-p-cymene)(κ2-diterpene)Cl] Induced by Natural Kaurenoic and Beyerenoic Acids [0.03%]
由天然卡urenoic和beyerenoic酸诱导的手性 organometallic atropoisomers [(ru(η6-p-cymene)(κ2-diterpene))cl]类化合物
Mayra A Martínez-Torres,Antonio J Oliveros-Ortiz,Ana K Villagómez-Guzmán et al.
Mayra A Martínez-Torres et al.
Chirality is an interesting property in molecules with a plethora of potential applications. In this line, due to their origin, most chiral natural compounds can be considered enantiopure, and many of these molecules include interesting fun...
Enantioselective Chiral Separation and Quantitation of PI3Kγ Inhibitor Eganelisib in Rat Plasma Using UHPLC-MS/MS: Application to Evaluate Pharmacokinetic Study [0.03%]
基于UHPLC-MS/MS的手性拆分定量分析EGANELISIB及其药代动力学研究
A R Priyadharshni,Jony Susanna Kandula,Dayasagar Rajiv Karkile et al.
A R Priyadharshni et al.
Eganelisib (EGN, IPI-549), an investigational new drug, is a potent first-in-class PI3Kγ inhibitor with high selectivity compared to other class I PI3K isoforms, with one asymmetric center. Enantiomers have similar physicochemical properti...
A Design of Experiments-Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations [0.03%]
一种基于实验设计的用于测定特拉唑帕尼及其对映体纯度的光学HPLC方法及应用
Sakine Atila Karaca,Sona Aliyeva,Duygu Yeniceli
Sakine Atila Karaca
Talazoparib is an oral inhibitor of the polyadenosine 5'-diphosphoribose polymerase enzymes used for the treatment of adults with deleterious or suspected deleterious germline BRCA-mutated, human epidermal growth factor receptor 2-negative,...
Enantiomers of Ruthenium(II) Complex [Ru(bpy)2(qip)]2+ Exhibit Highly Chiral-Selective Effects on the Stabilization of Third Strand of Triplex RNA Poly(U-A*U) [0.03%]
手性配位化合物[Ru(bpy)₂(qip)]²⁺几何异构体对三链RNA·A∶Poly(U-A*U)中第三链稳定作用的不对称效应研究
Xinxin Ling,Lifeng Tan
Xinxin Ling
Two chiral Ru(II) complexes bearing a quinoline ring, Λ-[Ru(bpy)2(qip)]2+ (Λ-1) and Δ-[Ru(bpy)2(qip)]2+ (Δ-1, where bpy = 2,2'-bipyridine and qip = 2-(quinolin-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline), were prepared. Their interacti...
Asymmetric Homogeneous Oxidation Reactions Catalyzed by First-Row Transition Metal Complexes [0.03%]
第一过渡系列金属配合物催化不对称均相氧化反应
Geeta Devi Yadav,Deepa Uppal,Priyanka Jhajharia et al.
Geeta Devi Yadav et al.
Asymmetric homogeneous oxidation reactions catalyzed by first-row transition metal complexes have been summarized, focusing on the performance of the chiral catalyst and its relation with the key factors (structure of the chiral ligands, ty...
Evaluation of Acetonitrile in Combination With Alcohols as Modifiers in Chiral Supercritical Fluid Chromatography [0.03%]
乙腈与醇类组合用作手性超临界流体色谱改性的评价研究
Lei Yue,Kaylee Quick,Adam Beard et al.
Lei Yue et al.
This study systematically investigated the effect of acetonitrile (ACN) in combination with alcohols as modifiers for chiral supercritical fluid chromatography (SFC) separations. The elution profiles of nine internal samples were evaluated ...