Enantioselective Chiral Separation and Quantitation of PI3Kγ Inhibitor Eganelisib in Rat Plasma Using UHPLC-MS/MS: Application to Evaluate Pharmacokinetic Study
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Eganelisib (EGN, IPI-549), an investigational new drug, is a potent first-in-class PI3Kγ inhibitor with high selectivity compared to other class I PI3K isoforms, with one asymmetric center. Enantiomers have similar physicochemical properties but differ in the... ...
