A Convenient Strategy to Access Diverse Libraries of Amphiphilic Compounds Based on Glycopeptoids [0.03%]
一种基于糖肽拟物的两亲性化合物多样化库的合成方法
Ludovica Dei,Stefano Cadeddu,Claude Taillefumier et al.
Ludovica Dei et al.
A convergent synthetic approach has been developed to access a potentially wide library of amphiphilic glycopeptoids. The intrinsic modularity of apolar peptoid units, coupled with the ability to conjugate various two-headed monosaccharide ...
Anthony Boudier,Guillaume Raffy,Emilie Pouget et al.
Anthony Boudier et al.
We report enantioselective crystallization of tetraphenylethylene (TPE) directed by chiral silica nanohelices (SNHs), yielding crystalline assemblies with distinct morphologies and chiroptical signatures that are modulated by both template ...
AQbD-Guided Chiral HPLC for Enantiomeric Impurity Analysis of Suzetrigine [0.03%]
基于AQbD的手性HPLC拆分苏泽特林光学异构体纯度测定方法研究
Sultanah M N Alhunayhin,Ayman M Algohary,Saja A Althobaiti et al.
Sultanah M N Alhunayhin et al.
Suzetrigine (SUZ), an analgesic for acute pain, requires strict enantiomeric purity control. This study develops a robust chiral HPLC method for SUZ and its R-enantiomer using analytical quality by design (AQbD). Separation was achieved on ...
Recent Progress in the Total Synthesis and Biosynthesis of Arborisidine [0.03%]
近年Arborisidine全合成与生物合成研究进展
Shiqi Dong,Kunxiao Shi,Ju Guo et al.
Shiqi Dong et al.
As a significant representative of monoterpenoid indole alkaloids (MIAs) and 1,1-disubstituted tetrahydro-β-carboline (THβC) alkaloids, Arborisidine, since its discovery in 2016 by Kam and coworkers, has emerged as a focal molecule in the...
Advances in Chiral Separation Techniques for Calcium Channel Blockers: Analytical Strategies and Future Perspectives in Antihypertensive Drug Development (2015-2025) [0.03%]
手性分离技术在钙离子通道阻滞剂中的进展：抗高血压药物开发（2015-2025）的分析策略和未来展望
Savita Umarani,Erica Alves,Manasa Chittipolu et al.
Savita Umarani et al.
Chirality plays a crucial role in pharmaceutical development, as enantiomers often display distinct therapeutic, pharmacokinetic, and safety profiles. Calcium channel blockers (CCBs), a cornerstone in antihypertensive therapy, frequently po...
Practical Enantioselective Approach to 3-Amino-2-Hydroxy Acids and Application to the Synthesis of Natural Products [0.03%]
实用性的对映选择性研究3-氨基-2-羟基酸及其在合成天然物质中的应用
Marilena Caporale,Giulia Marsico,Ernesto Santoro et al.
Marilena Caporale et al.
A practical approach to optically active erythro 3-amino-2-hydroxy acids has been developed and applied to the enantioselective synthesis of 3-phenylisoserine and naturally occurring 3-amino-2-hydroxy-6-methylheptanoic acid (AHMHA), a nonpr...
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods [0.03%]
手性（立体选择性）药物、不对称合成及消旋体拆分方法
Burcu Karayavuz,Cigdem Karaaslan Kirmizioglu
Burcu Karayavuz
Chirality is of great importance in drug development since both biological targets in the organism and the majority of pharmacologically active compounds created today are chiral. The synthesis and resolution of chiral compounds are critica...
Capillary Chiral Separation of Agrochemicals: Complementary Insights From Molecular Modeling and NMR [0.03%]
农业化学品的手性毛细管分离：分子建模和NMR的互补见解
Imran Ali,Ann Gogolashvili,Lali Chankvetadze et al.
Imran Ali et al.
The study investigates the capillary electrophoretic enantioseparation of agrochemicals (dichloroprop and mecoprop) using modified cyclodextrins 2-hydroxypropyl-β-cyclodextrin (CD-1), heptakis (2,3-di-O-methyl)-β-cyclodextrin (CD-2), hept...
Simultaneous Determination and Enantiomeric Separation of Five DL-Thiol Compounds Using UHPLC-HRMS With Chiral Derivatization in Sake: Dynamic Monitoring of Human Urine After Drinking [0.03%]
使用手性衍生化UHPLC-HRMS法同时测定和拆分日本清酒中的五种DL-硫醇化合物及其人体代谢动态监测方法
Shuyun Xiao,Hang Shi,Shuyi Song et al.
Shuyun Xiao et al.
Sake, a fermented alcoholic beverage made from rice and Aspergillus oryzae through microbial fermentation, contains thiol compounds that are the primary source of its distinctive sweet aroma. However, to date, there has been no report on th...
Palladium Schiff Base Complex-Modified Ti (MIL-125) Metal-Organic Frameworks as an Efficient Catalyst for Asymmetric Suzuki Coupling Reactions [0.03%]
用于不对称苏叶醇偶联反应的修饰型钯席夫碱配体Ti(MIL-125)金属有机框架高效催化剂
Jamal Kouhdareh
Jamal Kouhdareh
This work presents the design, synthesis, and catalytic evaluation of a novel heterogeneous organometallic catalyst, fabricated through the immobilization of a palladium-Schiff base complex onto the amino-functionalized titanium-based metal...