Integrated proteomic, phosphoproteomic, and N-glycoproteomic analyses of small extracellular vesicles from C2C12 myoblasts identify specific PTM patterns in ligand-receptor interactions [0.03%]
整合蛋白组、磷酸化蛋白质组和N-连接糖蛋白质组分析C2C12肌管细胞来源的小细胞外囊泡可识别受体相互作用中的特定PTM模式
Xiulan Chen,Xi Song,Jiaran Li et al.
Xiulan Chen et al.
Small extracellular vesicles (sEVs) are important mediators of intercellular communication by transferring of functional components (proteins, RNAs, and lipids) to recipient cells. Some PTMs, including phosphorylation and N-glycosylation, h...
Yunda Fang,Zhengjun Li,Lili Yang et al.
Yunda Fang et al.
Traditionally, lactate has been considered a 'waste product' of cellular metabolism. Recent findings have shown that lactate is a substance that plays an indispensable role in various physiological cellular functions and contributes to ener...
Simona D&#x;Aguanno,Matteo Brignone,Stefano Scalera et al.
Simona D&#x;Aguanno et al.
Introduction: Bcl-2 and Bcl-xL are the most studied anti-apoptotic members of Bcl-2 family proteins. We previously characterized both of them, not only for their role in regulating apoptosis and resistance to therapy in c...
Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion [0.03%]
细胞通讯网络因子1通过诱导中性粒细胞滞留和释放中性粒细胞胞外陷阱促进糖尿病视网膜病变血管渗漏
Ting Li,Yixia Qian,Haicheng Li et al.
Ting Li et al.
Background: Diabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil stasis, resulting in retinal inflammation and the occlusion of retinal mi...
Tumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming [0.03%]
肿瘤来源的ENTPD2外泌体通过ATP-腺苷代谢重编程影响结直肠癌中CD8+t细胞的功能
Mengchen Shi,Linsen Ye,Lu Zhao et al.
Mengchen Shi et al.
Background: Extracellular ATP-AMP-adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the conversion of ATP to AMP is primarily catalysed by Ectonucleoside trip...
The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis [0.03%]
半乳糖凝集素-1和-8通过多价相互作用调节FGFR1内吞的作用及其多样性
Dominika Żukowska,Aleksandra Chorążewska,Krzysztof Ciura et al.
Dominika Żukowska et al.
Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface receptor tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast growth factors (FGFs), initiates an intracellular signaling. FGFR1 s...
Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1 [0.03%]
补体调理素Ficolin-A诱导巨噬细胞向不同于经典M1表型的新促炎表型极化
Li-Wen Zhu,Zihao Li,Xiaohong Dong et al.
Li-Wen Zhu et al.
Background: Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the...
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways [0.03%]
TREM2敲低通过JAK2/STAT3和NF-κB信号通路促进促炎性小胶质细胞极化并抑制胶质瘤进展
Yunji Yan,Shengwei Bai,Hongxi Han et al.
Yunji Yan et al.
Background: In the tumor immune microenvironment (TIME), triggering receptor expressed on myeloid cells 2 (trem2) is widely considered to be a crucial molecule on tumor-associated macrophages(TAMs). Multiple studies have ...
Exploring the neuroprotective role of artesunate in mouse models of anti-NMDAR encephalitis: insights from molecular mechanisms and transmission electron microscopy [0.03%]
青蒿素在抗N-甲基-D-天冬氨酸受体脑炎小鼠模型中的神经保护作用：分子机制及透射电子显微镜观察的启示
Jingsi Liu,Yingyi Huang,Tinglin Qian et al.
Jingsi Liu et al.
Background: The pathway involving PTEN-induced putative kinase 1 (PINK1) and PARKIN plays a crucial role in mitophagy, a process activated by artesunate (ART). We propose that patients with anti-N-methyl-D-aspartate recep...
Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation [0.03%]
单细胞和空间转录组揭示了β-防御素基因家族在小鼠精子成熟过程中的时空特异性
Guoliang Zhang,Yuanchao Sun,Minkai Guan et al.
Guoliang Zhang et al.
Low sperm motility is a significant contributor to male infertility. beta-defensins have been implicated in host defence and the acquisition of sperm motility; however, the regulatory mechanisms governing their gene expression patterns and ...