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The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis

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Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface receptor tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast growth factors (FGFs), initiates an intracellular signaling. FGFR1 signaling ensures hom... ...