Cardiomyocytes HIPK2 regulates myocardial inflammation and heart function through purinergic signaling [0.03%]
Sultan Tousif,Arvind Singh Bhati,Allen Sam Titus et al.
Sultan Tousif et al.
Purinergic signaling is critical to myocardial inflammation and function. However, the underlying mechanisms are not well defined. Herein, we identified a protein kinase, homeodomain-interacting protein kinase 2 (HIPK2), as a novel regulato...
Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis [0.03%]
Jorge Díaz,Samuel Martínez-Meza,María Fernanda González et al.
Jorge Díaz et al.
Background: Neuroinflammation induces astrogliosis, a process marked by astrocyte hypertrophy, increased migration, and altered protein expression. While these changes involve both up- and downregulation of specific genes...
Acrodysostosis type 1: mechanisms explaining PRKAR1A mutation mediated dysregulation of cAMP-PKA signalling [0.03%]
Harry Moxom,Susan J Kimber
Harry Moxom
Acrodysostosis type 1 (ACRDYS1) is a rare multisystem developmental disorder affecting skeletal growth, endocrine function, neurodevelopment, metabolism, and tooth formation. It is caused by heterozygous mutations in PRKAR1A, which encodes ...
CELF family of RNA-binding proteins: roles in disease biology and potential for therapeutic intervention [0.03%]
Yukang Ma,Chi Ma,Aobo Yang et al.
Yukang Ma et al.
The CUG-BP and Elav-like (CELF) family of RNA-binding proteins are key regulators of post-transcriptional gene expression, coordinating alternative splicing, mRNA stability, and translation. Although individual members, particularly CELF1 a...
Decoding the metabolic cipher of dormant cancer cells: molecular mechanisms and therapeutic potentials [0.03%]
Yuao Qin,Junling Zhang,Yuyang Xiao et al.
Yuao Qin et al.
Dormant cancer cells (DCCs) are non-proliferative cancer cells that enter cell cycle arrest in the G0-G1 phase and are recognized as a major cause of therapeutic resistance and cancer recurrence. In response to various intracellular and ext...
Zifan Song,Shi Song,Nan Wang et al.
Zifan Song et al.
Early embryonic development in mammals involves extensive intercellular communication and interaction. The rapidly changing signaling pathways, governed by signaling pathway-related genes (SPGs), underlie these intricate communication netwo...
Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction [0.03%]
Céline Badot,Anaïs Bini,Eric Duplan et al.
Céline Badot et al.
Background: The amyloid β (Aβ) precursor C99 (or APP-βCTF) accumulates in Alzheimer's disease and has been proposed to display Aβ-independent toxicity, notably by affecting the endosomal-lysosomal-autophagic (ELA) net...
Defective branched-chain amino acid catabolism promotes pulmonary fibrosis by inducing apoptosis resistance of myofibroblasts in mice [0.03%]
Da-Yan Xiong,Chen-Yu Zhang,Yan-Feng Zhang et al.
Da-Yan Xiong et al.
Background: Pulmonary fibrosis (PF) is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Branched-chain amino acids (BCAAs) are a group of essential amino acids consisting o...
Pusong Zhao,Peng Wang,Tianqi Xu et al.
Pusong Zhao et al.
Synthetic lethality (SL) is a genetic interaction phenomenon in which a cell can survive when either of two genes is individually mutated, but simultaneous disruption of both genes leads to cell death. This phenomenon reveals the redundancy...
Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring [0.03%]
Jingxian Deng,Lu Li,Zhuoying Huang et al.
Jingxian Deng et al.
While obesity causes male infertility through testicular lipid stress, the mechanisms by which this stress alters Sertoli cell-derived extracellular vesicles (EVs) to induce paternal reproductive defects and offspring metabolic dysfunction ...