Radost A Saß,Christian H Bucher,Sabine Bartosch et al.
Radost A Saß et al.
Therapeutic interventions for diseases such as leukemia and autoimmune disorders are increasingly designed to selectively target and deplete specific immune cell subsets over prolonged periods. This can disrupt the homeostasis of the adapti...
Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment [0.03%]
基于组织硬度的血小板活化在乳腺癌防治中的潜在作用及机制研究
Menikae K Heenkenda,Xingyue Wang,Wen Zhong et al.
Menikae K Heenkenda et al.
Background: High mammographic breast density is a strong independent risk factor for sporadic breast cancer, yet involved mechanisms remain poorly defined. The extracellular compartment plays a critical role in the interc...
Cardiac function in zebrafish embryos is linked to an androgen receptor-adrenomedullin-proepicardium axis [0.03%]
斑马鱼胚胎心脏功能与雄激素受体-肾上腺髓质素-心外膜轴相关联
Max Duong Phu,Alessandra Guerrero Samanidis,Sabrina Laibacher et al.
Max Duong Phu et al.
Background: Congenital heart defects (CHDs) comprise the most common congenital malformation affecting nearly 1% of all newborns. In individuals with sex chromosome aneuploidy syndromes, however, the prevalence reaches up...
Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter [0.03%]
间质WNT信号在小鼠尿道发育过程中协调上皮和间质分化
Mark-Oliver Trowe,Philipp Straube,Florian Bergmann et al.
Mark-Oliver Trowe et al.
Background: The coordinated development of the mesenchymal and epithelial primordia of the murine ureter requires intense tissue communication. Previous studies have revealed the crucial role of the FGFR2-SHH-FOXF1-BMP4 s...
Caveolae in cancer: mechanochemical signaling in tumor progression, immunity, and therapy [0.03%]
细胞囊泡在癌症中的作用：肿瘤进展、免疫和治疗过程中的机械化学信号通路
Wen Cai,Xinlei Li,Yifan Chen et al.
Wen Cai et al.
Caveolae are specialized, flask-shaped invaginations of the plasma membrane enriched in cholesterol, sphingolipids, and other membrane lipids that serve as multifunctional hubs for signal transduction, endocytosis, and mechanosensing. Their...
Oligonucleotide G3T19 downregulates CD44 succinylation and inhibits astrocyte-induced glioma immune escape [0.03%]
寡核苷酸G3T19通过下调CD44琥珀酰化抑制星形胶质细胞介导的胶质瘤免疫逃逸
Xiaoming Sun,Xinyu Wang,Saijun Zhang et al.
Xiaoming Sun et al.
Background: Astrocytes (ACs) play a crucial role within the immune microenvironment of glioma, facilitating its progression. Protein succinylation, a post-translational modification, may serve as a significant regulatory ...
DRP1 lysine 616 lactylation exacerbates cerebral ischemia-reperfusion injury by activating the STING inflammatory pathway [0.03%]
DRP1赖氨酸616乳酸化通过激活STING炎症通路加重脑缺血再灌注损伤
Xiaoqi Ma,Dan Xin,Xianjia Li et al.
Xiaoqi Ma et al.
Ischemia-hypoxia-induced inflammation and glycolysis are linked to the severity of cerebral ischemia-reperfusion injury (CIRI), but the mechanisms are unclear. Current research suggests that the inflammatory response of immune cells activat...
Targeting the mevalonate pathway sensitizes multiple myeloma cells to bortezomib through induction of mitochondrial metabolic disruption [0.03%]
靶向甲羟戊酸途径通过诱导线粒体代谢紊乱使多发性骨髓瘤细胞对硼替佐米敏感化
Shuya Li,Na Hu,Xiaodong Li et al.
Shuya Li et al.
Background: Multiple myeloma (MM) remains an incurable hematologic malignancy with bortezomib resistance representing a major therapeutic challenge. The mevalonate (MVA) pathway, a crucial metabolic cascade involved in ch...
Pulmonary megakaryocytes orchestrate host defense via PcrV-induced NF-κB signaling in Pseudomonas aeruginosa infection [0.03%]
铜绿假单胞菌感染中肺巨核细胞通过PcrV诱导的NF-κB信号协调宿主防御功能
Xiaolong Guo,Qian Dai,Xiping Liao et al.
Xiaolong Guo et al.
Background: Megakaryocytes, beyond their classical role in platelet formation, are increasingly recognized as immune modulators. This study aimed to investigate the function and activation mechanisms of megakaryocytes dur...
Activity-based proteomics analysis revealed that DNJ directly targeted ATP5F1 to alleviate high glucose induced cardiomyocyte injury [0.03%]
基于蛋白质组学分析发现DNJ通过直接作用于ATP5F1缓解高糖诱导的心肌细胞损伤
Xue Li,Yiwei Chen,Huixin Yang et al.
Xue Li et al.
Background: Diabetic cardiomyopathy (DCM) is a significant complication of diabetes mellitus, characterized by impaired cardiac function and mitochondrial injury. The natural alkaloid 1-deoxynojirimycin (DNJ) has exhibite...