Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction
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Background: The amyloid β (Aβ) precursor C99 (or APP-βCTF) accumulates in Alzheimer's disease and has been proposed to display Aβ-independent toxicity, notably by affecting the endosomal-lysosomal-autophagic (ELA) network. O... ...
