Integrative experimental and computational analysis of a bioactivity guided fraction of Potentilla fulgens targeting oxidative stress and inflammatory pathways in diabetic neuropathy [0.03%]
基于生物活性导向的牛繁缕药效成分通过调控氧化应激和炎症通路改善糖尿病神经病变的实验及计算研究
Sm Abdul Aziz Barbhuiya,Partha Pratim Dutta,Chandana Choudhury Barua et al.
Sm Abdul Aziz Barbhuiya et al.
Diabetic neuropathy (DN), driven by oxidative stress and inflammation, was investigated for its therapeutic modulation by a column derived bioactive fraction of Potentilla fulgens (PFCF3) using integrated in vitro, in vivo and computational...
Pressurised liquid extraction of arylbutanoid and diarylheptanoid glycosides from Betula pubescens phloem [0.03%]
Betula pubescens树干皮中压流体提取阿维丁和茋苷类化合物
Danil I Falev,Alexandra A Onuchina,Ilya S Voronov et al.
Danil I Falev et al.
Birch phloem (inner bark) is primarily burned as waste in the pulp and paper, forestry and wood processing industries. However, phloem represents a valuable source of biologically active plant secondary metabolites. In this study, we propos...
Passiflora edulis Sims. cultivated in Sicily: chemical profile, antioxidant activity and antimicrobial potential of its passion fruit [0.03%]
萨克森地区种植的自模拟 Passionflora edulis 的化学特征、抗氧化和抗菌活性
Eleonora Di Salvo,Giovanna Lo Vecchio,Laura De Maria et al.
Eleonora Di Salvo et al.
Passiflora edulis Sims., a tropical species valued for passion fruit also known as maracuja, due to climate change, is now cultivated also in Mediterranean regions. Passion fruit juice processing generates by-products that may represent val...
Diterpenoid compounds isolated from Salvia majdae (Rech.f. & Wendelbo) Sytsma show antiproliferative and apoptosis inducing capacity against cancer cells [0.03%]
萨福克虫草素对癌细胞的抗增殖和促凋亡作用研究
Zahra Nazemosadat-Arsanjani,Alireza Poustforoosh,Somayeh Pirhadi et al.
Zahra Nazemosadat-Arsanjani et al.
Salvia majdae (Rech.f. & Wendelbo) Sytsma (Lamiaceae) is a monotypic species endemic to southern Iran. The ethanol extract of its dried roots was fractionated with n-hexane, yielding salvipisone (4) and a mixture of β-sitosterol (8) with s...
Synthesis and antitumor activity of novel tanshinone derivatives with amino acid esters [0.03%]
新型丹参素衍生物与氨基酸酯类化合物的合成及抗肿瘤活性
Dongdong Wang,Xinli Song,Yibo Yu et al.
Dongdong Wang et al.
The clinical development of natural product tanshinone for cancer therapy is hindered by its weak potency and poor drug-like properties. In this study, a systematic structural modification of tanshinone I and tanshinone IIA was conducted to...
A blueberry-derived polysaccharide inhibits SARS-CoV-2 papain-like protease and exhibits broad-spectrum anti-coronavirus activity [0.03%]
一种越橘多糖抑制SARS-CoV-2 3CL蛋白酶并具有广谱抗冠状病毒活性
Guangyi Chen,Chenxin Zhang,Bo Feng et al.
Guangyi Chen et al.
Vaccinium corymbosum (blueberry) is widely regarded as a functional food, the antiviral potential of blueberry polysaccharides has not yet been explored. In this study, a polysaccharide fraction designated 2B4 was isolated from blueberry fr...
Evaluation of the nematicidal effect of Smoke Water against Meloidogyne javanica and Aphelenchus avenae in vitro [0.03%]
烟水对植物寄生线虫的离体杀灭效果研究
Mahsa Meftahi,Giuseppina Iacomino,Alessia Staropoli et al.
Mahsa Meftahi et al.
Smoke water (SW), a liquid by-product of wood pruning waste pyrogasification, was investigated for its nematicidal potential. We evaluated SW's efficacy against adult Aphelenchus avenae and the egg and second-stage juveniles (J2) of the roo...
Liuping Yu,Jiahe Niu,Jiandong Zhang et al.
Liuping Yu et al.
Protosappanin A, a polyphenolic natural product bearing a unique 6H-dibenzo[b,d]oxocin-7(8H)-one moiety, is an important and novel monomer component of Caesalpinia sappan L. that exerts a variety of promising biological activities. Herein, ...
LC-MS/MS-based dereplication and molecular networking of Ficus superba with identification and quantification of furanocoumarins [0.03%]
基于LC-MS/MS的无核果树枝解重复和分子网络及其富喃香豆素的鉴定与定量
Muhammad Afiffikri Ahmad,Sarah Sofea Mohd Sali,Nur Hanis Syuhada Abdul Rauf et al.
Muhammad Afiffikri Ahmad et al.
Ficus superba (Moraceae) is a limestone-associated plant species from Malaysia that remains chemically unexplored. This study aimed to establish the phytochemical profile of its bark, leaves, and twigs using an untargeted mass spectrometry-...
Monoterpenoids from the roots of Paeonia lactiflora Pall. and their neuroprotective activity [0.03%]
Paeonia lactiflora白芍根中单萜类成分及其神经保护作用研究
Bo Fu,Yi-Qiang Zhang,Jin-Ling Zhang et al.
Bo Fu et al.
Three novel monoterpenoids (1-3), together with nine known ones (4-12), were isolated from the roots of Paeonia lactiflora Pall. The newly discovered monoterpenoids were structurally characterised by detailed spectroscopic analysis. Further...