Steady-state thermal homeostasis model of heat generated and dissipated in the human retina [0.03%]
人眼视网膜产热和散热的稳态热平衡模型
Christina Kiel,Alexander James E Foss
Christina Kiel
The retina is both metabolically active and exposed to light, resulting in persistent heat generation. However, the quantitative contributions of metabolic and irradiative heat sources, and the mechanisms responsible for dissipating this th...
Effect of high mobility group box-1 on receptor for advanced glycation endproducts (RAGE) and toll-like receptor-4 (TLR4) diffusion and signaling [0.03%]
高迁移率族蛋白箱蛋白1对晚期糖基化终产物受体和 Toll 样受体-4 扩散及信号转导的影响
Sharifur Rahman,Chamari S Wijesooriya,Gennady V Pogorelko et al.
Sharifur Rahman et al.
High mobility group box-1 (HMGB1) is a damage-associated molecular pattern (DAMP) and a ligand for multiple immune receptors, including receptors for advanced glycation endproducts (RAGE) and toll-like receptor 4 (TLR4). Binding of HMGB1 to...
Scaling of the Bicoid morphogen gradient: the effect of state dependent diffusion [0.03%]
态依赖扩散的双胞体形态素梯度尺度变化
Priya Chakraborty,Shyam Balaji Iyer,Richa Rikhy et al.
Priya Chakraborty et al.
The mechanisms underlying the scaling of the Bicoid morphogen gradient in Drosophila with the embryo size is not clearly understood. We propose a model with a spatially varying diffusion coefficient along the anterior-posterior axis, that i...
Wnt signaling modulates tissue mechanics, actin order, and regeneration in Hydra vulgaris [0.03%]
Wingless信号通路调节水母体机械性能、肌动蛋白排序及再生
Thomas Perros,Stéphane Joly,Adama Mbaye et al.
Thomas Perros et al.
Hydra vulgaris is a powerful model organism in the study of axial patterning and regeneration. While recent models emphasize the importance of mechanical cues in establishing the body axis of Hydra tissue spheres, the precise role of the Wn...
A cross-scale physical framework for transcription-associated CPEB4 microexon susceptibility and crowding-enhanced isoform self-association: toward a biophysical mechanism of idiopathic autism [0.03%]
与转录相关的精神分裂症易感基因CPEB4微外显子的物理框架及增强型同种异体结合：向特发性孤独症生物物理机制迈进
Ysaías Alvarado,Arlene Cardozo,Alejandro Vivas et al.
Ysaías Alvarado et al.
Co-transcriptional splicing and protein self-assembly are governed by coupled kinetic and thermodynamic constraints, such that modest changes in exon processing can propagate into substantial shifts in isoform-dependent mesoscale behavior. ...
Hiba Khan,Paula Garcia-Galindo,Sebastian E Ahnert et al.
Hiba Khan et al.
A /emph{morphospace} is an abstract space of theoretically possible biological traits, shapes, or property values. It is interesting to explore which parts of a morphospace life occupies, as compared to those parts which could be occupied, ...
Dynamical Modeling and Bifurcation Analysis of Malaria Transmission under Synergistic Control of Wolbachia-Infected Male Release and Chemical Insecticides [0.03%]
沃尔巴克菌雄虫释放和化学杀虫剂协同作用下的疟疾传播动力学建模与分岔分析
Xinyu Wang,Wei Zhou,Liping Wang
Xinyu Wang
In this article, we integrate the release of Wolbachia-carrying male mosquitoes with chemical insecticide spraying to formulate a coupled model that incorporates mosquito stage structure and malaria transmission dynamics. The model accounts...
Quantitative models of photoreceptor metabolisms: implications for rod outer segment length, retinal glycolysis and choroidal blood flow [0.03%]
视杆细胞代谢的定量模型及其对视紫红质外节长度、视网膜糖酵解和脉络膜血流量的影响
Christina Kiel,Stella Prins,Alexander James E Foss
Christina Kiel
The outer retina exhibits several distinctive physiological features, including continuous turnover of rod photoreceptor outer segments (OS), a strong reliance on aerobic glycolysis despite oxygen availability, and an unusually high rate of...
Mechanical Interactions Govern Self-Organized Ordering in Bacterial Colonies on Surfaces [0.03%]
力学相互作用决定细菌表面群落的自组织行为
Samaneh Rahbar,Ludger Santen,Reza Shaebani
Samaneh Rahbar
Bacterial colonies growing on surfaces are shaped by mechanical stresses transmitted through the community, governed by the balance between cell growth and steric and cell-substrate interactions. Using overdamped dynamics simulations of non...
Robert G Endres
Robert G Endres
Bacterial chemotaxis has long been viewed as operating near the physical limits of sensing, as originally articulated by Berg and Purcell. Recent information-theoretic analyses challenge this view, suggesting that Escherichia coli uses only...