Decoding intrinsically disordered regions in chromatin dysfunction and cancer [0.03%]
染色质功能障碍和癌症中内在无序区域的解读
Audrey W Hong,Colleen E Hannon,Amy R Strom
Audrey W Hong
Intrinsically disordered regions (IDRs) are pervasive in chromatin regulatory proteins, where their dynamic, multivalent interactions organize nuclear biochemistry, in some cases through biomolecular condensation. Because ∼20% of cancer-dr...
Hac1-independent functions of Ire1 drive morphogenesis in Candida albicans through distinct transcriptional programs [0.03%]
通过不同的转录程序，Ire1的Hac1非依赖性功能通过独立的转录程序驱动白念珠菌的形态发生
Samuel Stack-Couture,Gabriela Nunes Marsiglio Librais,Bryan Lung et al.
Samuel Stack-Couture et al.
The pathogenic yeast Candida albicans relies on morphogenesis-the transition from spherical yeast to filamentous hyphal forms-for infection. While morphogenesis requires Ire1, a transmembrane protein that canonically initiates the Unfolded ...
N-cadherin mediates replicative senescence of mesenchymal stem cells via regulation of intercellular adhesion [0.03%]
N-钙黏着蛋白通过调节细胞间粘附介导间充质干细胞的复制衰老
Xiangyu Dong,Qian Sun,Mengchen Tu et al.
Xiangyu Dong et al.
Human mesenchymal stem cells (hMSCs) undergo progressive functional decline during long-term ex vivo expansion, which limits their therapeutic potential. However, the contribution of intercellular adhesion to this process remains unclear. B...
Live imaging of epithelial phagocyte differentiation in the Drosophila ovary reveals transient and novel behaviors [0.03%]
果蝇卵巢上皮吞噬细胞分化活体成像揭示了短暂且新颖的行为特征
Caique Almeida Machado Costa,Cristian Santiago Santiago,Jie Sun et al.
Caique Almeida Machado Costa et al.
The transformation of epithelial cells into non-professional phagocytes (NPPs) is a conserved and versatile adaptation that occurs in response to immune challenges, tissue remodeling and apoptotic debris clearance. In the Drosophila melanog...
The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter [0.03%]
围绕秀丽隐杆线虫中心体的细胞膜网络可能是一种微管过滤器
Richa Maheshwari,Mohammad M Rahman,Abigail Ruddick et al.
Richa Maheshwari et al.
Centrosomes are cytoplasmic microtubule-nucleating structures. They are considered membraneless organelles, but in several cell types they are surrounded by ER-derived membrane. In C. elegans early embryos, this membrane forms a dense membr...
Regulation of Leishmania surface coat proteins by the nuclear protein ESB1 [0.03%]
ESB1调控莱什曼原虫表层蛋白涂层的机制研究
Jorge Adrián Arias Del Angel,Ulrich Dobramysl,Laura Davidson et al.
Jorge Adrián Arias Del Angel et al.
Unicellular Leishmania parasites cause leishmaniases and require a life cycle stage-specific surface coat for pathogenesis. A major protein component of this coat is δ-amastins, which are human infective amastigote life cycle stage-specifi...
Getting nuclear size just right - emerging mechanisms regulating nuclear scaling and morphology [0.03%]
核大小的调控机制——调节核尺度和形态的新观点
Haritha Prabha,Priscilla Phan,Daniel L Levy
Haritha Prabha
It has been known for over a century that nuclear size generally scales with cell size, and nuclear morphology aberrations have long been used for disease diagnosis and prognosis, most notably in cancers. Over the past several decades, an e...
Apical-out polarity in epithelial spheroids requires α6β4 integrins, cell proliferation, and anchorage-independence [0.03%]
顶基极性需要α6β4整合素、细胞增殖和非依附性锚定
Niharika Patel,Jenna Pirrello,Skylar Lynch et al.
Niharika Patel et al.
Epithelial cells primarily segregate transmembrane proteins to apical or basal surfaces, establishing apical-basal polarity. For 3D tissues, apical proteins face inwards. Recent work by our group showed that increased RhoA activation causes...
Yitao Shen,Alexis T Weiner,Pankajam Thyagarajan et al.
Yitao Shen et al.
Microtubule seeds are short, uncapped microtubule fragments that can reinitiate growth. Whether they exist in cells in vivo has not been demonstrated. In Drosophila neurons, many microtubules are dynamic at both ends. When tracking behavior...
Split GFP-based fluorescent biosensors detect ER-Golgi membrane contact dynamics [0.03%]
分裂型GFP荧光生物传感器可检测内质网-高尔基体膜接触动态
Ranran Mao,Jiaqi Zhai,Chunfang Tong et al.
Ranran Mao et al.
In eukaryotic cells, organelles communicate through membrane contact sites-specialized regions where their membranes come into close apposition without fusing. Among these, contacts between the endoplasmic reticulum (ER) and the Golgi appar...