Getting nuclear size just right - emerging mechanisms regulating nuclear scaling and morphology [0.03%]
核大小的调控机制——调节核尺度和形态的新观点
Haritha Prabha,Priscilla Phan,Daniel L Levy
Haritha Prabha
It has been known for over a century that nuclear size generally scales with cell size, and nuclear morphology aberrations have long been used for disease diagnosis and prognosis, most notably in cancers. Over the past several decades, an e...
Apical-out polarity in epithelial spheroids requires α6β4 integrins, cell proliferation, and anchorage-independence [0.03%]
顶基极性需要α6β4整合素、细胞增殖和非依附性锚定
Niharika Patel,Jenna Pirrello,Skylar Lynch et al.
Niharika Patel et al.
Epithelial cells primarily segregate transmembrane proteins to apical or basal surfaces, establishing apical-basal polarity. For 3D tissues, apical proteins face inwards. Recent work by our group showed that increased RhoA activation causes...
Yitao Shen,Alexis T Weiner,Pankajam Thyagarajan et al.
Yitao Shen et al.
Microtubule seeds are short, uncapped microtubule fragments that can reinitiate growth. Whether they exist in cells in vivo has not been demonstrated. In Drosophila neurons, many microtubules are dynamic at both ends. When tracking behavior...
Split GFP-based fluorescent biosensors detect ER-Golgi membrane contact dynamics [0.03%]
分裂型GFP荧光生物传感器可检测内质网-高尔基体膜接触动态
Ranran Mao,Jiaqi Zhai,Chunfang Tong et al.
Ranran Mao et al.
In eukaryotic cells, organelles communicate through membrane contact sites-specialized regions where their membranes come into close apposition without fusing. Among these, contacts between the endoplasmic reticulum (ER) and the Golgi appar...
The kinetochore component HCP-1 forms cytoplasmic granules in C. elegans germline [0.03%]
C. elegans生殖细胞中的动粒蛋白成分HCP-1形成胞质颗粒
Hannah L Hertz,Ian F Price,Wen Tang
Hannah L Hertz
The kinetochore is a multiprotein complex that assembles on centromeric chromatin and serves as the attachment site for spindle microtubules, thereby ensuring accurate chromosome segregation during cell division. Here we present evidence th...
Zeinab Rekad,Stavroula Mili,Ellen Van Obberghen-Schilling et al.
Zeinab Rekad et al.
Adhesion to the extracellular environment is fundamental for cell survival, differentiation, proliferation and migration as well as for overall tissue organization. Although RNA-binding and RNA regulatory proteins have often been observed i...
Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153 [0.03%]
细胞分裂和NUP153介导的早熟衰老相关核膜重塑
Ayse Mubine Turkmen,Jing Wang,Adam Frost et al.
Ayse Mubine Turkmen et al.
The nuclear envelope (NE) undergoes dynamic remodeling during both physiological and pathological processes. Nuclei in cells from patients with accelerated aging diseases and from elder individuals are often lobular and convoluted. Despite ...
Ritobrata Ghose,Victoria Sanz-Moreno
Ritobrata Ghose
Amoeboid behaviour represents a distinct and clinically significant cancer cell state within the epithelial-to-mesenchymal transition (EMT) spectrum. Defined by the loss of cell-cell junctions and adoption of a rounded morphology, amoeboid ...
Multiple ammonium transporters in fission yeast are coordinated by transcriptional and localization regulation in response to nitrogen starvation [0.03%]
模式酵母通过转录和定位调控协调多种铵转运蛋白响应氮饥饿反应
Yukiko Nakase,Ng Shet Lee,Amelia Tan Cheng Wei et al.
Yukiko Nakase et al.
Ammonium is a preferred nitrogen source for microorganisms. We investigated the regulation of ammonium transporters Amt1, Amt2, and Amt3 in the fission yeast Schizosaccharomyces pombe. Expression of the amt1+ gene increases under nitrogen s...
Escorting mRNAs - the multifunctional and divergent roles of cap-chaperones in post-transcriptional gene expression [0.03%]
携陪信使RNA：转录后基因表达中多功能且多样的冠伴侣的作用
Caleb M Embree,Katherine L B Borden
Caleb M Embree
Transcripts undergo a variety of processing steps - including splicing, nuclear export and translation - to ultimately produce their protein product in the required form. Deviations in these steps can produce proteins with altered or ablate...