The plant kinesin-12 POK2 tail is a versatile interaction hub [0.03%]
植物驱动蛋白KCH/Kinesin-12的尾部结构域POK2是多功能的结合枢纽
Shu Yao Leong,Laura Muras,Benedikt S J Fischer et al.
Shu Yao Leong et al.
Tissue development and function rely on correct cell patterning. In plants, patterns are determined by the new cell wall formed during mitosis. Already in preprophase, ring-like, positional cues mark the future division plane on the plasma ...
Three-dimensional beating pattern of ciliary tip in the live ciliate Tetrahymena [0.03%]
四膜虫活细胞中 eyelid 小棒状纤毛尖端的三维摆动模式
Akisato Marumo,Hiroto Ishii,Shin Yamaguchi et al.
Akisato Marumo et al.
Ciliates utilise motile cilia, which are highly dynamic organelles protruding from the cell surface, to swim helically in a three-dimensional (3D) space. The 3D nature of its swimming behaviour and rapid ciliary beatings make its quantitati...
Drosophila and human cell studies reveal a conserved role for CEBPZ, NOC2L, and NOC3L in rRNA processing and tumorigenesis [0.03%]
CEBPZ、NOC2L和NOC3L在rRNA处理和肿瘤发生中的保守作用的果蝇与人类细胞研究揭示了这一点
Guglielmo Rambaldelli,Valeria Manara,Andrea Vutera Cuda et al.
Guglielmo Rambaldelli et al.
NOC1, NOC2, and NOC3 are evolutionarily conserved nucleolar proteins that play an essential role in the maturation and processing of ribosomal RNA (rRNA). NOC1, in Drosophila is necessary to sustain rRNA processing, whereas its depletion le...
Asymmetries in the three-dimensional beat of Chlamydomonas reinhardtii flagella revealed by holographic microscopy [0.03%]
利用全息显微镜揭示绿色鞭毛藻(Chlamydomonas reinhardtii)三维摆动的不对称性
Laurence G Wilson,Martin A Bees
Laurence G Wilson
We present the first three-dimensional, time-resolved imaging of the Chlamydomonas reinhardtii flagellar waveform. This freshwater alga is a model system for eukaryotic flagella that allow cells to move and pump fluid. During the power stro...
Microtubules regulate tissue-level navigation in skin-resident macrophages [0.03%]
微管调节皮肤驻留巨噬细胞的组织水平导航
Eric Peterman,Andrew Murphy,Ian A Swinburne et al.
Eric Peterman et al.
Immune cells rapidly respond to tissue damage through dynamic properties of the cytoskeleton. How microtubules control immune cell functions during injury responses remains poorly understood. Within skin, tissue-resident macrophages known a...
Michael Stern
Michael Stern
In youth, energy deprivation primarily results from fasting. Because inconsistent nutrient availability is common for most organisms, natural selection has provided mechanisms that detect nutrient-deprived states, followed by adaptive respo...
Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease [0.03%]
肾组织驻留巨噬细胞促进早期多囊性肾脏疾病囊肿形成
Rudolfo Karl,Arsila Palliyulla Kariat Ashraf,Maria Francesca Viola et al.
Rudolfo Karl et al.
Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a ciliopathy characterized by mutations in PKD1 or PKD2, which drive cystogenesis in renal epithelial cells. Immune cells, particularly macrophages, contribute to disease progression, ...
Nonuple atg8 mutant provides genetic evidence for functional specialization of ATG8 isoforms in Arabidopsis thaliana [0.03%]
拟南芥九突体atg8突变体提供了功能特化的atg8同工型的基因证据
Alessia Del Chiaro,Nenad Grujic,Jierui Zhao et al.
Alessia Del Chiaro et al.
Autophagy sustains cellular health by recycling damaged or excess components through autophagosomes. It is mediated by conserved ATG proteins, among which the ubiquitin-like ATG8 protein plays a central role by linking cargo to the growing ...
An in vivo model of apoptosis: linking cell behaviours and caspase substrates in embryos lacking DIAP1 [0.03%]
一个关于细胞凋亡的体内模型：DIAP1缺乏胚胎中细胞行为和半胱氨酸天冬氨酸酶底物之间的关系
Dhianjali Chandraratna,Nicola Lawrence,David P Welchman et al.
Dhianjali Chandraratna et al.
The apoptotic phenotype is characterised by dynamic changes in cell behaviours such as cell rounding and blebbing, followed by chromatin condensation and cell fragmentation. Whereas the biochemical pathways leading to caspase activation hav...
Desmoplakin tail domain position in the desmosomal plaque is isoform dependent [0.03%]
尾结构域在胞质斑中的定位依赖于亚型
Collin M Ainslie,Krishna Patel,Yen T B Tran et al.
Collin M Ainslie et al.
Desmoplakin (DP) is a key protein in desmosomes, cell-cell junctions that provide mechanical integrity to the skin and heart. DP has three isoforms, DPI, DPIa, and DPII which differ only in the length of their central rod domain and arise f...