Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease
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Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a ciliopathy characterized by mutations in PKD1 or PKD2, which drive cystogenesis in renal epithelial cells. Immune cells, particularly macrophages, contribute to disease progression, yet their role remai... ...
