Endothelial cell biomechanical adaptation to altered connexin 43 expression under fluid shear stress [0.03%]
流体切应力下缝隙连接蛋白43表达改变对内皮细胞生物力学适应的影响
Md Mydul Islam,Vignesharavind Subramanianbalachandar,Robert Steward
Md Mydul Islam
We examined how pharmacological modulation of connexin 43 (Cx43) regulates endothelial biomechanics under static conditions and laminar fluid shear stress (FSS). Cx43 activity was either inhibited with 2',5'-dihydroxychalcone (chalcone) or ...
rRNA transcription is regulated by sequestering LATS2 and PHF6 to the nuclear speckle following DNA damage [0.03%]
DNA损伤后LATs2和PHF6被募集到核内点状结构调控rRNA转录
Hirokazu Suzuki,Satomi Mukai,Yorika Kato et al.
Hirokazu Suzuki et al.
Mammalian large tumor suppressor 2 (LATS2) is an evolutionarily conserved Ser/Thr kinase that regulates the Hippo signaling pathway and cell cycle checkpoints. In this study, we demonstrate that ultraviolet (UV) irradiation causes the phosp...
Establishing MS2-MCP-based single-molecule RNA visualization in Schizosaccharomyces pombe [0.03%]
在模式生物粟酒裂殖酵母中建立MS2-MCP单分子RNA原位可视化技术
Douglas E Weidemann,Sarah C Turner,Samir G Chethan et al.
Douglas E Weidemann et al.
Single-molecule RNA imaging using the MS2-MCP system has transformed the study of RNA biology across model organisms. However, this technology has remained unavailable for fission yeast (Schizosaccharomyces pombe) even though fission yeast ...
LGI1-ADAM22 complex organizes PSD93 clustering at the axon initial segment [0.03%]
LGI1-ADAM22复合物可组织PSD93在轴突初始段的聚集
Wenying Zhang,Shuyi Tan,Xiaoyu Teng et al.
Wenying Zhang et al.
Postsynaptic density-93 (PSD93) is a membrane-associated guanylate kinase (MAGUK) family scaffolding protein containing multiple PDZ domains. It assembles ion channels, receptors, and signaling molecules at synaptic and axonal membranes, pa...
Potential role of myeloid bodies in protection against photo-oxidative damage of the retinal pigment epithelium [0.03%]
关于髓样体在视网膜色素上皮光氧化损伤保护中的潜在作用
Iñigo Novales Flamarique
Iñigo Novales Flamarique
Myeloid bodies are organized forms of the smooth endoplasmic reticulum that occur in the retinal pigment epithelium of vertebrates. The latter is a monolayer of cells, situated between the neural retina and the chroroid vasculature, that is...
From the FAZ to the TAC: Widespread cytoskeletal engagement of T. brucei KMP11 [0.03%]
从FAZ到TAC：KMP11在布氏锥虫细胞骨架的广泛参与
Salome Aeschlimann,Clirim Jetishi,Caroline E Dewar et al.
Salome Aeschlimann et al.
KMP11 is a conserved kinetoplastid protein yet its precise localization and function remained unclear. Using immunofluorescence, ultrastructure expansion microscopy (U-ExM), and proteomics, we comprehensively analyzed KMP11 in procyclic Try...
Branched actin segregates endocytic cargo to control sorting and fission [0.03%]
分枝.actin.将内吞货物隔离以控制分类和裂解
Devin Frisby,Naava Naslavsky,Steve Caplan
Devin Frisby
At the early endosome, cargos are sorted into subdomains; receptors destined for recycling to the plasma membrane are sorted into tubulovesicular structures that undergo fission and release cargo-laden vesicles that traffic along microtubul...
FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism [0.03%]
FAM122A通过双结合机制抑制PP2A-B55
Iker Benavides-Puy,Suzanne Vigneron,Arminja N Kettenbach et al.
Iker Benavides-Puy et al.
FAM122A regulates cell cycle progression through inhibition of the PP2A-B55 phosphoprotein phosphatase. Recent structural work has uncovered helical elements in the N-terminus of FAM122A as binding determinants for PP2A-B55 but whether FAM1...
Hemmo Meyer,Akiko Kuma,Shuhei Nakamura
Hemmo Meyer
The limiting membrane of lysosomes is prone to damage that can have deleterious consequences for cellular homeostasis. Cells respond to this damage with an array of molecular countermeasures, ranging from membrane repair mechanisms to elimi...
Megan C King,Abby Buchwalter
Megan C King