A conserved domain of Cfap298 governs left-right symmetry breaking in vertebrates [0.03%]
脊椎动物左右对称性破缺取决于Cfap298的保守区域
Marvin Cortez,Cullen B Young,Katherine A Little et al.
Marvin Cortez et al.
Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in Left-Right (LR) patterning in zebrafish and links to human ciliopathies. Here we describe a Cfap298 mutant allele, Cfap298ΔΔS, w...
Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2 [0.03%]
前列腺素E2通过岩针依赖性激活ROCK2抑制脂肪细胞生成
Mark D Lee,Keren I Hilgendorf
Mark D Lee
Functional adipose tissue is essential for maintaining systemic metabolic homeostasis. Dysfunctional adipose tissue, characterized by increased fibrosis, hypoxia, and chronic inflammation, is often associated with obesity and promotes the o...
The Company of Biologists and the British Society for Cell Biology: a long-standing relationship [0.03%]
《生物学家学会与英国细胞生物学协会：长期合作关系》
Saanjbati Adhikari
Saanjbati Adhikari
The British Society for Cell Biology (BSCB), established in 1965, is a charitable organisation that 'aims to promote research and exchange of information relating to all branches of cell biology'. The Society hosts and supports meetings and...
'First Persons' through the decades - 100 years of notable scientists in Journal of Cell Science [0.03%]
百年来《细胞生物学杂志》刊登的杰出科学家们
Amelia Glazier
Amelia Glazier
In 2017, Journal of Cell Science (JCS) began inviting the first authors of published research articles to share a bit about themselves and their work through our 'First Person' short interview series, with the aim of helping early-career re...
Oligomerization and exocyst coupling underlie Spa2-mediated focusing of polarized growth in fission yeast [0.03%]
寡聚化和外泌体耦合是裂殖酵母中Spa2介导的极性生长聚焦的基础
Liping Ren,Alaina H Willet,Kathleen L Gould
Liping Ren
Polarized cell growth in fungi requires the spatial restriction of exocytosis to discrete cortical domains. Defined by a characteristic domain architecture, the evolutionarily conserved scaffold protein Spa2 localizes to sites of polarized ...
Dynein-2 requires HSP90 chaperone activity to ensure robust retrograde IFT and ciliogenesis [0.03%]
HSP90分子伴侣活性对强有力的逆向IFT及纤毛发生至关重要
Tiago J Dantas,Diogo M Abreu,Maria J G De-Castro et al.
Tiago J Dantas et al.
The microtubule motor dynein-2 is responsible for retrograde intraflagellar transport (IFT), a process critical for cilia assembly and cilium-dependent signaling. Mutations in genes encoding dynein-2 subunits interfere with ciliogenesis and...
ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and reveals a role for ARL13B in spermatogenesis [0.03%]
ARL13B-Cerulean补救Arl13b敲除小鼠的胚胎致死性并揭示ARL13B在精子发生中的作用
Alyssa B Long,Isabella M Wilson,Tiffany T Terry et al.
Alyssa B Long et al.
ARL13B is a regulatory GTPase enriched in cilia, making it a popular marker for this organelle. Arl13bhnn/hnn mice lack ARL13B expression, die during midgestation, and exhibit defects in ciliogenesis. The R26Arl13b-Fucci2aR biosensor mouse ...
Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes [0.03%]
表皮生长因子受体是E-钙粘蛋白力转导复合物的重要组成部分
Yubo Zou,Nicolas Allen,Emaan Rauf et al.
Yubo Zou et al.
We present evidence that the association of Epithelial (E)-cadherin (CHD1) extracellular domain and epidermal growth factor receptor (EGFR, ErbB1) is obligatory for cadherin force transduction signaling. E-cadherin and EGFR associate at cel...
Basement membranes at a glance [0.03%]
基底膜小知识
Rachel Lennon,David R Sherwood
Rachel Lennon
Basement membranes (BMs) underlie or surround most tissues. They are formed of secreted proteins that associate with cell surfaces and are the most ancient animal extracellular matrix. Laminin and collagen IV are core components that polyme...
Nadav Scher,Ori Avinoam
Nadav Scher
Secretory granules are specialized vesicles that package large amounts of cargo, such as hormones, enzymes and mucous. They are typically stored intracellularly until an extracellular signal initiates exocytosis, characterized by fusion bet...