Branched actin segregates endocytic cargo to control sorting and fission [0.03%]
分枝.actin.将内吞货物隔离以控制分类和裂解
Devin Frisby,Naava Naslavsky,Steve Caplan
Devin Frisby
At the early endosome, cargos are sorted into subdomains; receptors destined for recycling to the plasma membrane are sorted into tubulovesicular structures that undergo fission and release cargo-laden vesicles that traffic along microtubul...
FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism [0.03%]
FAM122A通过双结合机制抑制PP2A-B55
Iker Benavides-Puy,Suzanne Vigneron,Arminja N Kettenbach et al.
Iker Benavides-Puy et al.
FAM122A regulates cell cycle progression through inhibition of the PP2A-B55 phosphoprotein phosphatase. Recent structural work has uncovered helical elements in the N-terminus of FAM122A as binding determinants for PP2A-B55 but whether FAM1...
Hemmo Meyer,Akiko Kuma,Shuhei Nakamura
Hemmo Meyer
The limiting membrane of lysosomes is prone to damage that can have deleterious consequences for cellular homeostasis. Cells respond to this damage with an array of molecular countermeasures, ranging from membrane repair mechanisms to elimi...
Megan C King,Abby Buchwalter
Megan C King
Pascal Höhne,Marie Hugenroth,Maria Bohnert
Pascal Höhne
The nucleus-vacuole junction (NVJ) is a central membrane contact site in yeast that connects the nuclear endoplasmic reticulum and the vacuole. This organelle interface is heavily involved in the handling of lipids: it houses numerous lipid...
Loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoids [0.03%]
INPP5E的丢失影响了由人多能干细胞衍生视网膜类器官中的感光细胞外节膜的生成
Kae R Whiting,Mariam G Aslanyan,Lynn van Summeren et al.
Kae R Whiting et al.
Mutations in the ciliary gene INPP5E, encoding inositol polyphosphate-5-phosphatase E (INPP5E), can cause retinal degeneration as part of the ciliopathy Joubert Syndrome or non-syndromic retinitis pigmentosa (RP). INPP5E regulates the membr...
Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells [0.03%]
Brinker调控干细胞与分化细胞之间BMP信号的相互作用结果
Samaneh Poursaeid,Jeffrey P Gamer,Mayu Inaba
Samaneh Poursaeid
Drosophila male germline stem cells (GSCs) reside at the testis tip, surrounding a cluster of niche cells known as the hub. Bone Morphogenetic Protein (BMP) ligands secreted from the hub exert both contact-dependent and -independent effects...
Primary cilium disassembly - from mechanisms to roles in physiology and disease [0.03%]
原纤毛解聚-从机制到生理和疾病中的作用
Carolyn M Ott,Jennifer Lippincott-Schwartz,David K Breslow
Carolyn M Ott
Primary cilia are micron-scale cellular compartments with key roles in cell signaling and disease. Cilium assembly has been delineated as a multi-step process that is disrupted in ciliopathies, yet many features of cilia disassembly remain ...
Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae [0.03%]
隐性端粒附近基因表达需要凝缩素的泛素化修饰
Deepash Kothiwal,Shalu Joseph,Shikha Laloraya
Deepash Kothiwal
Cohesin, first described for its role in sister chromatid cohesion, impacts several chromosomal processes, some of which (chromosome segregation, replication and repair) are regulated by its post-translational modifications. Previously, we ...
Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest [0.03%]
库姆洛斯细胞通过促进DNA损伤诱导的减数分裂停滞来增强卵母细胞的基因组质量控制能力
Chenxi Zhou,Brett McKinnon,Hayden Homer
Chenxi Zhou
Cumulus cells are known to maintain oocyte arrest at prophase I through gap junction-mediated cAMP signalling, but their role after meiotic resumption remains unclear. Here, we show that cumulus cells enhance oocyte genomic quality control ...