Cell migration signaling through EGFR-VAV2-Rac1 pathway is sustained in endosomes [0.03%]
EGFR-VAV2-Rac1信号通路通过内吞体维持细胞迁移信号
Itziar Pinilla-Macua,Sachin Surve,Alexander Sorkin
Itziar Pinilla-Macua
Ligand binding to EGFR activates Rho family GTPases, triggering actin cytoskeleton reorganization, cell migration and invasion. Activated EGFR is also rapidly endocytosed but the role of EGFR endocytosis in cell motility is poorly understoo...
The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3 [0.03%]
新型基质蛋白SNED1通过RGD结合整合素α5β1和αvβ3介导细胞粘附
Dharma Pally,Nandini Kapoor,Alexandra Naba
Dharma Pally
The extracellular matrix (ECM) is a complex meshwork comprising over 100 proteins. It serves as an adhesive substrate for cells and, hence, plays critical roles in health and disease. We have recently identified a novel ECM protein, SNED1, ...
Casein kinase 1 controls components of a TORC2 signaling network in budding yeast [0.03%]
酪蛋白激酶1调控芽殖酵母中TORC2信号传导网络的组分
Rafael Lucena,Akshi Jasani,Steph Anastasia et al.
Rafael Lucena et al.
Tor kinases play diverse and essential roles in control of nutrient signaling and cell growth. These kinases are assembled into two multiprotein complexes known as TORC1 and TORC2. In budding yeast, TORC2 relays nutrient-dependent signals t...
Fantastic proteins and where to find them - histones, in the nucleus and beyond [0.03%]
组蛋白的奇遇记——核小体内外的历史痕迹
Johanna Grinat,Noah P Shriever,Maria A Christophorou
Johanna Grinat
Animal genomes are packaged into chromatin, a highly dynamic macromolecular structure of DNA and histone proteins organised into nucleosomes. This accommodates packaging of lengthy genomic sequences within the physical confines of the nucle...
Fis1 regulates mitochondrial morphology, bioenergetics, and removal of mtDNA damage in irradiated glioblastoma cells [0.03%]
Fis1调节放射诱导的胶质母细胞瘤细胞中的线粒体形态、生物能学以及mtDNA损伤的清除
Yuli Buckley,Maria S K Stoll,Charles L Hoppel et al.
Yuli Buckley et al.
In response to external stress, mitochondrial dynamics is often disrupted, but the associated physiologic changes are often uncharacterized. In many cancers, including glioblastoma (GBM), mitochondrial dysfunction has been observed. Underst...
Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres [0.03%]
人类肌纤维末端单核细胞和肌核组织的肌纤维类型差异
Christian Hoegsbjerg,Ask Møbjerg,Ching-Yan Chloé Yeung et al.
Christian Hoegsbjerg et al.
The myotendinous junction (MTJ) is a weak link in the musculoskeletal system. Here, we isolated the tips of single myofibres from healthy human hamstring muscles for confocal microscopy (n=6) and RNAscope in situ hybridisation (n=6) to gain...
An evolutionary perspective on the relationship between kinetochore size and CENP-E dependence for chromosome alignment [0.03%]
从进化角度解析着丝粒区域大小与染色体排列的CENP-E依赖性之间的关系
Ana C Almeida,Helder Rocha,Maximilian W D Raas et al.
Ana C Almeida et al.
Chromosome alignment during mitosis can occur as a consequence of bi-orientation or is assisted by the CENP-E (kinesin-7) motor at kinetochores. We previously found that Indian muntjac chromosomes with larger kinetochores bi-orient more eff...
Julie Welburn
Julie Welburn
TXNDC15, an ER-localized thioredoxin-like transmembrane protein, contributes to ciliary transition zone integrity [0.03%]
定位于内质网的类硫氧还蛋白跨膜蛋白TXNDC15对纤毛转换区完整性具有重要作用
Shingo Yamazaki,Taiju Fujii,Shuhei Chiba et al.
Shingo Yamazaki et al.
Primary cilia have specific proteins on their membrane to fulfill their sensory functions. Preservation of the specific protein composition of cilia relies on the barrier function of the transition zone (TZ) located at the ciliary base. Def...
Phase separation of microtubule-binding proteins - implications for neuronal function and disease [0.03%]
微管结合蛋白的相分离及其对神经元功能和疾病的影响
Daisy Duan,Anthony J Koleske
Daisy Duan
Protein liquid-liquid phase separation (LLPS) is driven by intrinsically disordered regions and multivalent binding domains, both of which are common features of diverse microtubule (MT) regulators. Many in vitro studies have dissected the ...