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Cell migration signaling through EGFR-VAV2-Rac1 pathway is sustained in endosomes

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Ligand binding to EGFR activates Rho family GTPases, triggering actin cytoskeleton reorganization, cell migration and invasion. Activated EGFR is also rapidly endocytosed but the role of EGFR endocytosis in cell motility is poorly understood. Hence, we used li... ...