Cadherins and Growth Factor Receptors: ligand selective mechano-switches at cadherin junctions [0.03%]
钙粘着蛋白和生长因子受体：黏着斑上的配体选择性机械开关功能
Vinh Vu,Brendan Sullivan,Evan Hebner et al.
Vinh Vu et al.
This study investigated possible mechanisms underlying differences between heterophilic and homophilic cadherin adhesions that influence intercellular mechanics and multicellular organization. Results suggest that homophilic cadherin ligati...
Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology [0.03%]
GPC耦联受体信号传导和药理学的定量研究方法
Abigail Pearce,Theo Redfern-Nichols,Edward Wills et al.
Abigail Pearce et al.
G protein-coupled receptor (GPCR) signalling pathways underlie numerous physiological processes, are implicated in many diseases and are major targets for therapeutics. There are more than 800 GPCRs, which together transduce a vast array of...
Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression [0.03%]
GLI2和GLI3通过Gli1表达在成骨分化中的拮抗作用
Yuto Takahashi,Yamato Ishida,Saishu Yoshida et al.
Yuto Takahashi et al.
The GLI1/GLI2/GLI3 transcription factors mediate Hedgehog (Hh) signaling, which is crucial for bone development. During intramembranous ossification, mesenchymal stem cells (MSCs) are directly differentiated into osteoblasts. Under basal an...
The conserved K3 residue in the N-terminal region of Rab10 small GTPase is required for tubular endosome formation: N-terminal tagging causes Rab10 dysfunction [0.03%]
Rab10小G蛋白N端保守的K3残基对管状内吞体形成是必需的：N端标签导致Rab10功能障碍
Rinka Hata,Akira Sugawara,Mitsunori Fukuda
Rinka Hata
Various N-terminal tags have often been used to identify the functions and localization of Rab small GTPases, but their impact on Rab proteins themselves has been poorly investigated. Here, we used a knockout (KO)-rescue approach to systema...
Mitochondrial phosphatase PPTC7 promotes EGFR recycling by facilitating VPS4A endosomal localization [0.03%]
线粒体磷酸酶PPTC7通过促进VPS4A内体定位来促进EGFR循环利用
Rahul Baroi,Hilal Ahmad Reshi,SubbaReddy Maddika
Rahul Baroi
PPTC7 is a mitochondrial phosphatase that is essential for mitochondrial biogenesis, metabolism, protein content maintenance and transport. While the mitochondrial roles of PPTC7 are well-characterized, its roles outside the mitochondria ar...
A protein interaction map of the myosin Myo2 reveals a role of Alo1 in mitochondrial inheritance in yeast [0.03%]
Myo2蛋白的蛋白质相互作用组图揭示了酵母中Alo1在细胞质分裂中期的线粒体遗传中的作用
Xenia Chelius,Nathalie Rausch,Veronika Bartosch et al.
Xenia Chelius et al.
Budding yeast cells multiply by asymmetric cell division. During this process, the cell organelles are transported by myosin motors along the actin cytoskeleton into the growing bud, while at the same time some organelles must be retained i...
Point contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion [0.03%]
点接触限制型cAMP信号控制ephrin-A5诱导的轴突排斥作用
Johann Bécret,Claudia Gomez-Bravo,Camille Michaud et al.
Johann Bécret et al.
Signal transduction downstream of axon guidance molecules is essential to steer developing axons. Second messengers including cAMP are key molecules shared by a multitude of signaling pathways and are required for a wide range of cellular p...
Rabin8 phosphorylated by NDR2/STK38L, the canine early retinal degeneration (erd) gene product, directs rhodopsin Golgi-to-cilia trafficking [0.03%]
由NDR2/STK38L(erd基因编码的产物)磷酸化的Rab8介导视紫红质从高尔基体向纤毛运输
Theresa Fresquez,Beatrice M Tam,Shannon C Eshelman et al.
Theresa Fresquez et al.
The Rab11-Rabin8-Rab8 ciliogenesis complex regulates the expansion of cilia-derived light-sensing organelles, the rod outer segments, via post-Golgi rhodopsin transport carriers (RTCs). Rabin8, an effector of Rab11 and a nucleotide exchange...
Sarah J Bray,Stephen J Royle,Holly A Shiels et al.
Sarah J Bray et al.
Biochemical and biophysical mechanisms macrophages use to tune phagocytic appetite [0.03%]
巨噬细胞调节吞噬热力学的生化和生物物理机制
Annalise Bond,Meghan A Morrissey
Annalise Bond
Macrophages phagocytose, or eat, pathogens, dead cells and cancer cells. To activate phagocytosis, macrophages recognize 'eat me' signals like IgG and phosphatidylserine on the target cell surface. Macrophages must carefully adjust their ph...